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Global Gamma Delta T Cell Cancer Therapy Market Opportunity & Clinical Trials Insight 2030

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    Report

  • 240 Pages
  • June 2024
  • Region: Global
  • Kuick Research
  • ID: 5574917
Description Jump to:

Report Highlights:

  • Number of Gamma Delta T Cell Therapies in Trials: > 30 Therapies
  • US & China Dominating Clinical Trials Landscape: > 20 Therapies
  • Global Gamma Delta T Cell Therapy Clinical Trials Insight by Company, Country, Indication & Phase
  • Gamma Delta T Cell Therapy Future Market Opportunity by Different Cancers
  • Insight on Clinical Platforms for Evolving Gamma Delta T Cell Therapy: > 10 Platforms by Companies
  • Ongoing Clinical Research & Development Trends by Different Cancers
  • Insights on 12 Companies Developing Gamma Delta T Cell Therapies

After vicennium of futuristic T cells entrenched immunotherapy dominating the treatment landscape of cancer arena, there is a prerequisite to branch out cancer immunotherapy realm by developing other state-of-the-art therapies. But in spite of that, this led to discovery of other T cells receptors, such as gamma delta T cells, alpha-beta T cell and others. Consecutively, finding of gamma delta T cells based immunotherapy (also recognized as γδ T cells), it was further pragmatic that developing gamma delta T cells based immunotherapies will aid to offer a innovatory treatment for cancer along with other disorders, including viral infections, autoimmune and inflammation.

With respect to statistics, the global clinical conduit of gamma delta T cells based immunotherapy comprises of 30 drugs (as of June 2024), several of which are in preclinical stage as well as majority of research and development along with technological advancement in in this sector is ongoing in the US and China region. Albeit, no drug has penetrated into the commercial market to treat cancer or other ailments; however, as soon as one drug will get approved will aid to launch other gamma delta T cells based immunotherapy into market and clenches potential to become a multimillionaire market in imminent.

One of the strategic prime movers that bestow to bourgeon the growth of gamma delta T cells based immunotherapy market is the rise in preclinical and clinical studies. Over the preceding decennium, the sphere of global gamma delta T cells based immunotherapy market has witnessed the development of several novel, innovative as well as advanced competitors. For instance, a clinical-stage biotechnology company in US, Acepodia Biotech has developed 2 contenders, ACE1708 as well as ACE2016 to treat solid tumor expressing PD-L1 accompanied with EGFR expressing tumors.

Coupled with this, the presences of various stakeholders in conjugation with investors from giant pharma companies accompanied with biotech companies, such as Bristol Myers Squibb, TC Biopharm, PersonGen BioTherapeutics, In8bio, Kiromic BioPharma, Immatics, Legend Biotech, Innate Pharma, Ever Supreme Bio Technology, Editas Medicine, CytoMed Therapeutics, Acepodia Biotech and other have bestowed to transform the treatment paradigm by developing up-to-the-minute gamma delta T cells based immunotherapy worldwide. Amid all these companies, PersonGen BioTherapeutics is the frontrunner in this segment as the company is developing 5 allogeneic UCAR- γδ1 T cell therapy for the treatment of autoimmune, T cell malignancies and other solid tumors. The presences of giant pharmaceuticals aid to conduct multitudinous clinical trials in gamma delta T cells based immunotherapy space.

Just as importantly, an inclining market trend towards developing avant-garde global gamma delta T cells based immunotherapy, such as developing gamma-delta gene editing based immunotherapy, is gaining spotlight amid healthcare professionals. For instance, a biotech company based in Germany, Immatics has collaborated with Bristol Myers Squibb and Editas Medicine in order To syndicate gamma-delta T cell based adoptive cell therapies in addition to gene editing for the treatment of cancer.

Until now, no gamma delta T cells based immunotherapies has been approved in global market; nevertheless, it can be anticipated that a handful of gamma delta T cells therapies will be launched into the market in approaching 5 to 7 years due to the fact that many gamma delta T cells based immunotherapies have received FDA designations which aid to accelerate the approval process. For instance, ADI-001 has gained utmost breakthrough as it has received FDA fast track designation for the potential treatment of relapsed/refractory B-cell non-Hodgkin lymphoma (NHL), in 2022, and relapsed/refractory class III or class IV lupus nephritis in June 2024. Overall, aforementioned illustrates clearly forecasts that the future of gamma delta T cells based immunotherapies will be propitious.

Table of Contents

1. Introduction To Gamma Delta T Cell Therapy
1.1 Emerging Role of T Cell Based Immunotherapies
1.2 Overview of Gamma Delta T Cell Therapy
1.3 Gamma Delta T Cell Therapy v/s Conventional Therapies

2. Role of Gamma Delta T Cells in Cancer
2.1 Gamma Delta T Cells in Cancer Progression
2.2 Anti Tumor Activity of Gamma Delta T Cells
2.3 Adopted Approaches for Gamma Delta T Cell Therapy

3. Global Gamma Delta T Cell Therapy Market Overview
3.1 Current Market Scenario
3.2 Market Potential of Gamma Delta T Cell Therapy Market

4. Global Gamma Delta T Cell Therapy Clinical Trials Overview
4.1 By Phase
4.2 By Country
4.3 By Company
4.4 By Indication
4.5 By Priority Status

5. Global Gamma Delta T Cell Therapy Clinical Trials Insight By Company, Country, Indication & Phase
5.1 Research
5.2 Preclinical
5.3 Phase I
5.4 Phase I/II
5.5 Phase II

6. Gamma Delta T Cell Therapy in Leukemia
6.1 Ongoing Clinical Research & Development Trends
6.2 Future Market Opportunity of Gamma Delta T Cells in Leukemia

7. Gamma Delta T Cell Therapy in Lung Cancer
7.1 Ongoing Clinical Research & Development Trends
7.2 Future Market Opportunity of Gamma Delta T Cell Therapy in Lung Cancer

8. Gamma Delta T Cells in Breast Cancer
8.1 Ongoing Clinical Research & Development Trends
8.2 Future Market Opportunity of Gamma Delta T Cell Therapy in Breast Cancer

9. Gamma Delta T Cells in Colorectal Cancer
9.1 Ongoing Clinical Research & Development Trends
9.2 Future Market Potential of Gamma Delta T Cell Therapy in Colorectal Cancer

10. Gamma Delta T Cells in Pancreatic Cancer
10.1 Ongoing Clinical Research & Development Trends
10.2 Future Market Potential of Gamma Delta Therapy in Pancreatic Cancer

11. Gamma Delta T Cells in Lymphoma
11.1 Ongoing Clinical Research & Development Trends
11.2 Future Outlook in Lymphoma

12. Gamma Delta T Cell Therapy in Brain Tumors
12.1 Research & Development in Brain Tumors
12.2 Future Outlook in Brain Tumors

13. Gamma Delta T Cell Therapy in Head & Neck Cancer
13.1 Research & Development in Head & Neck Cancer
13.2 Future Outlook in Head & Neck Cancer

14. Gamma Delta T Cell Therapy in Autoimmune, Inflammatory & Microbial Ailments
14.1 Research & Development in Autoimmune, Inflammatory & Microbial Ailments

15. Combination Methodologies for Gamma Delta T Cell Therapy16. Platforms for Evolving Gamma Delta T Cell Therapy
17. Gamma Delta T Cell Therapy Market Dynamics
17.1 Gamma Delta T Cell Therapy Market: Favorable Parameters
17.2 Gamma Delta T Cell Therapy Market: Challenges

18. Competitive Landscape
18.1 Acepodia
18.2 Adicet
18.3 Cytomed Therapeutics
18.4 Expression Therapeutics
18.5 Janssen Biotech
18.6 Gadeta
18.7 GammaDelta Therapeutics (Takeda)
18.8 IN8bio
18.9 Kiromic Biopharma
18.10 Lava Therapeutics
18.11 Regeneron Pharmaceuticals
18.12 TC Biopharm

List of Figures
Figure 1-1: History of T cell Based Immunotherapy
Figure 1-2: Gamma Delta T cell Therapy
Figure 1-3: Stimulants of Gamma Delta T Cells
Figure 1-4: Limitation of CAR T Cell Therapy
Figure 1-5: Limitations of TIL
Figure 1-6: Limitations of Monoclonal Antibodies
Figure 1-7: Drawbacks of Chemotherapeutic Drugs
Figure 2-1: Pro-Tumor Role of Gamma Delta T Cells
Figure 2-2: Antigen Presentation Functions of Gamma Delta T-Cells
Figure 2-3: Anti-Tumor Activity of Gamma Delta T-Cells
Figure 2-4: Gamma Delta T Cell Bispecific Antibodies - Mechanism of Action
Figure 2-5: Functional Advantages of ?d T Cells for CAR T Cancer Therapy
Figure 2-6: CAR ?d T Cells - Mechanism of Action
Figure 3-1: Global - Cell Therapy Market (US$ Billion), 2024 - 2030
Figure 3-2: Global - Gamma Delta T Cell Therapy Market Opportunity by 1% of Total Cell Therapy Market (US$ Billion), 2024-2030
Figure 3-3: Global - Gamma Delta T Cell Therapy Market Opportunity by 2% of Total Cell Therapy Market (US$ Billion), 2024-2030
Figure 3-4: Global - Gamma Delta T Cell Therapy Market Opportunity by 3% of Total Cell Therapy Market (US$ Billion), 2024-2030
Figure 3-5: Global - Gamma Delta T Cell Therapy Market Opportunity by 4% of Total Cell Therapy Market (US$ Billion), 2024-2030
Figure 3-6: Global - Gamma Delta T Cell Therapy Market Opportunity by 5% of Total Cell Therapy Market (US$ Billion), 2024-2030
Figure 3-7: Global - Gamma Delta T Cell Therapy Market Opportunity by 6% of Total Cell Therapy Market (US$ Billion), 2024-2030
Figure 3-8: Global - Gamma Delta T Cell Therapy Market Opportunity by 7% of Total Cell Therapy Market (US$ Billion), 2024-2030
Figure 3-9: Global - Gamma Delta T Cell Therapy Market Opportunity by 8% of Total Cell Therapy Market (US$ Billion), 2024-2030
Figure 3-10: Global - Gamma Delta T Cell Therapy Market Opportunity by 9% of Total Cell Therapy Market (US$ Billion), 2024-2030
Figure 3-11: Global - Gamma Delta T Cell Therapy Market Opportunity by 10% of Total Cell Therapy Market (US$ Billion), 2024-2030
Figure 4-1: Global - Gamma Delta T Cell Therapy Clinical Trials By Phase (Numbers), 2024 - 2030
Figure 4-2: Global - Gamma Delta T Cell Therapy Clinical Trials By Country (Numbers), 2024 - 2030
Figure 4-3: Global - Gamma Delta T Cell Therapy Clinical Trials By Company (Numbers), 2024 - 2030
Figure 4-4: Global - Gamma Delta T Cell Therapy Clinical Trials By Indication (Numbers), 2024
Figure 4-5: Global - Gamma Delta T Cell Therapy Clinical Trials By Priority Status (Numbers), 2024
Figure 6-1: Benefits of Gamma Delta T Cells in Leukemia
Figure 6-2: CD33CART Phase 1/2 (NCT03971799) Study - Initiation & Completion Year
Figure 6-3: CD33CART Phase 2 (NCT03971799) Study - Initiation & Completion Year
Figure 6-4: INB-100 Phase 1 (NCT03533816) Study - Initiation & Completion Year
Figure 6-5: Mechanism of Action of V?9/CD123 Bispecific Antibody
Figure 6-6: Global - Estimated Leukemia Cases, 2024-2030
Figure 6-7: US - Estimated Leukemia Cases, 2024-2030
Figure 6-8: Europe - Estimated Leukemia Cases, 2024-2030
Figure 6-9: China - Estimated Leukemia Cases, 2024-2030
Figure 6-10: Japan - Estimated Leukemia Cases, 2024-2030
Figure 7-1: Role of Gamma Delta T Cells in Lung Cancer
Figure 7-2: KB-GDT-01 Phase 1 (NCT06069570) Study - Initiation & Completion Year
Figure 7-3: Global - Estimated Lung Cancer Cases, 2024-2030
Figure 7-4: US - Estimated Lung Cancer Cases, 2024-2030
Figure 7-5: Europe - Estimated Lung Cancer Cases, 2024-2030
Figure 7-6: China - Estimated Lung Cancer Cases, 2024-2030
Figure 7-7: Japan - Estimated Lung Cancer Cases, 2024-2030
Figure 8-1: Global - Estimated Breast Cancer Cases, 2024-2030
Figure 8-2: US - Estimated Breast Cancer Cases, 2024-2030
Figure 8-3: Europe - Estimated Breast Cancer Cases, 2024-2030
Figure 8-4: China - Estimated Breast Cancer Cases, 2024-2030
Figure 8-5: Japan - Estimated Breast Cancer Cases, 2024-2030
Figure 9-1: Role of Gamma Delta T Cells in Colorectal Cancer
Figure 9-2: Mechanism Underlying B7-H3 Regulating ?d T Cells Killing Colon Cancer Cells
Figure 9-3: PF-08046052 Phase I (NCT05983133) Study - Initiation & Completion Year
Figure 9-4: Global - Estimated Colorectal Cancer Cases, 2024-2030
Figure 9-5: US - Estimated Colorectal Cancer Cases, 2024-2030
Figure 9-6: Europe - Estimated Colorectal Cancer Cases, 2024-2030
Figure 9-7: China - Estimated Colorectal Cancer Cases, 2024-2030
Figure 9-8: Japan - Estimated Colorectal Cancer Cases, 2024-2030
Figure 10-1: Auspicious Outcomes Gamma Delta T Cell Therapy
Figure 10-2: Role of Gamma Delta T Cells in Pancreatic Cancer Progression
Figure 10-3: Global - Estimated Pancreatic Cancer Cases, 2024-2030
Figure 10-4: US - Estimated Pancreatic Cancer Cases, 2024-2030
Figure 10-5: Europe - Estimated Pancreatic Cancer Cases, 2024-2030
Figure 10-6: China - Estimated Pancreatic Cancer Cases, 2024-2030
Figure 10-7: Japan - Estimated Pancreatic Cancer Cases, 2024-2030
Figure 11-1: ACE1831 Phase I (NCT05653271) Study - Initiation & Completion Year
Figure 11-2: ADI-001 Phase I (NCT04735471) Study - Initiation & Completion Year
Figure 11-3: Global - Estimated Lymphoma Cases, 2024-2030
Figure 11-4: US - Estimated Lymphoma Cases, 2024-2030
Figure 11-5: Europe - Estimated Lymphoma Cases, 2024-2030
Figure 11-6: China - Estimated Lymphoma Cases, 2024-2030
Figure 11-7: Japan - Estimated Lymphoma Cases, 2024-2030
Figure 12-1: DeltEx With Temozolomide (TMZ) Phase 1/2 (NCT05664243) Study - Initiation & Completion Year
Figure 12-2: IN8bio - Autologous (INB-400) & Allogeneic (INB-410) Candidates
Figure 12-3: ?d T Cells Phase 1 (NCT04165941) Study - Initiation & Completion Year
Figure 12-4: Aflac-NBL-2002 Phase 1 (NCT05400603) Study - Initiation & Completion Year
Figure 12-5: Global - Estimated Brain Cancer Cases, 2024-2030
Figure 12-6: US - Estimated Brain Tumor Cases, 2024-2030
Figure 12-7: Europe - Estimated Brain Tumor Cases, 2024-2030
Figure 12-8: China - Estimated Brain Tumor Cases, 2024-2030
Figure 12-9: Japan - Estimated Brain Tumor Cases, 2024-2030
Figure 13-1: Acepodia Biotech Clinical Pipeline Insight
Figure 13-2: Pfizer & Lava Therapeutics Collaboration
Figure 13-3L: SGN-EGFRd2 Phase 1 (NCT05983133) Study - Initiation & Completion Year
Figure 13-4: Global - Estimated Head & Neck Cancer Cases, 2024-2030
Figure 13-5: US - Estimated Head & Neck Cancer Cases, 2024-2030
Figure 13-6: Europe - Estimated Head & Neck Cancer Cases, 2024-2030
Figure 13-7: China - Estimated Head & Neck Cancer Cases, 2024-2030
Figure 13-8: Japan - Estimated Head & Neck Cancer Cases, 2024-2030
Figure 14-1: ADI-001 Phase 1 (NCT06375993) Study - Initiation & Completion Year
Figure 14-2: Adicet Bio ADI-001 Fast Track Designation
Figure 14-3: ImCheck Therapeutics - Clinical Candidates Indications & Mode of Action Insights
Figure 14-4: ICT21 - Mechanism of Action
Figure 15-1: Gamma Delta T Cell Therapy Combinations
Figure 16-1: IN8bio - DeltEx DRI Auto
Figure 16-2: Diamond AI - Prediction Engine
Figure 16-3: Diamond AI - Immune Surveillance
Figure 16-4: Acepodia - Antibody-Cell Conjugation
Figure 16-5: Lava Therapeutics - Gammabody Platform
Figure 16-6: Adicet Bio - Gamma Delta Cell Platform
Figure 16-7: ADI-001 - Gamma Delta Cell Therapy
Figure 16-8: Century Therapeutics - Allo-Evasion
Figure 16-9: ViGenCell - ViRanger Platform
Figure 16-10: Legend Biotech - CAR-?d T Platform
Figure 16-11: Immatics - ACTallo® Manufacturing Process
Figure 17-1: Global - Cancer Incidences & Mortality Rates (Billion), 2020 & 2040
Figure 17-2: Gamma Delta T Cells Favorable Market Parameters
Figure 17-3: Stages of Drug Development

List of Tables
Table 3-1: Candidates with Regulatory Designations
Table 6-1: Global - Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2024-2030
Table 6-2: US - Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2024-2030
Table 6-3: Europe - Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2024-2030
Table 6-4: China - Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2024-2030
Table 6-5: Japan - Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2024-2030
Table 7-1: Global - Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2024-2030
Table 7-2: US - Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2024-2030
Table 7-3: Europe - Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2024-2030
Table 7-4: China - Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2024-2030
Table 7-5: Japan - Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2024-2030
Table 8-1: Global - Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2024-2030
Table 8-2: US - Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2024-2030
Table 8-3: Europe - Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2024-2030
Table 8-4: China - Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2024-2030
Table 8-5: Japan - Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2024-2030
Table 9-1: Global - Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2024-2030
Table 9-2: US - Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2024-2030
Table 9-3: Europe - Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2024-2030
Table 9-4: China - Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2024-2030
Table 9-5: Japan - Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2024-2030
Table 10-1: Global - Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2024-2030
Table 10-2: US - Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2024-2030
Table 10-3: Europe - Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2024-2030
Table 10-4: China - Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2024-2030
Table 10-5: Japan - Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2024-2030
Table 11-1: Global - Estimated Adoption Rate of Gamma Delta T Cell in Lymphoma, 2024-2030
Table 11-2: US - Estimated Adoption Rate of Gamma Delta T Cell in Lymphoma, 2024-2030
Table 11-3: Europe - Estimated Adoption Rate of Gamma Delta T Cell in Lymphoma, 2024-2030
Table 11-4: China - Estimated Adoption Rate of Gamma Delta T Cell in Lymphoma, 2024-2030
Table 11-5: Japan - Estimated Adoption Rate of Gamma Delta T Cell in Lymphoma, 2024-2030
Table 12-1: Global - Estimated Adoption Rate of Gamma Delta T Cell in Brain Tumors, 2024-2030
Table 12-2: US - Estimated Adoption Rate of Gamma Delta T Cell in Brain Tumors, 2024-2030
Table 12-3: Europe - Estimated Adoption Rate of Gamma Delta T Cell in Brain Tumors, 2024-2030
Table 12-4: China - Estimated Adoption Rate of Gamma Delta T Cell in Brain Tumors, 2024-2030
Table 12-5: Japan - Estimated Adoption Rate of Gamma Delta T Cell in Brain Tumors, 2024-2030
Table 13-1: Global - Estimated Adoption Rate of Gamma Delta T Cell in Head & Neck Cancers, 2024-2030
Table 13-2: US - Estimated Adoption Rate of Gamma Delta T Cell in Head & Neck Cancers, 2024-2030
Table 13-3: Europe - Estimated Adoption Rate of Gamma Delta T Cell in Head & Neck Cancer, 2024-2030
Table 13-4: China - Estimated Adoption Rate of Gamma Delta T Cell in Head & Neck Cancers, 2024-2030
Table 13-5: Japan - Estimated Adoption Rate of Gamma Delta T Cell in Head & Neck Cancer, 2024-2030
Table 15-1: Ongoing Preclinical & Clinical Trials for Combination of Gamma Delta T Cell Therapy

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Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • Acepodia
  • Adicet
  • Cytomed Therapeutics
  • Expression Therapeutics
  • Gadeta
  • GammaDelta Therapeutics (Takeda)
  • IN8bio
  • Janssen Biotech
  • Kiromic Biopharma
  • Lava Therapeutics
  • Regeneron Pharmaceuticals
  • TC Biopharm

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About the Gamma Delta T Cell Cancer Therapy Market

In the realm of biotechnology, Gamma Delta (γδ) T cell cancer therapy is a form of immunotherapy that involves harnessing the unique abilities of γδ T cells to target and destroy tumor cells. γδ T cells are a subset of T cells that play a crucial role in the immune system's response to various infections and malignancies. Unlike the more common alpha beta (αβ) T cells, γδ T cells recognize antigens in a manner that is not restricted by the major histocompatibility complex (MHC), allowing them to respond to a broader range of cancer cell types. Biotechnological advancements have enabled the manipulation and expansion of γδ T cells outside of the body, which can then be reintroduced to the patient as a targeted therapy. This approach is considered promising due to its potential to minimize off-target effects and its applicability to a variety of cancers. Several companies are actively involved in the development and commercialization of γδ T cell therapies for cancer. These include TC Biopharm, Gadeta, and GammaDelta Therapeutics. Additionally, companies like Adaptimmune and Incysus Therapeutics are working to harness the power of γδ T cells, focusing on various strategies to optimize the specificity and effectiveness of these cells in combating cancer. The involvement of such enterprises illustrates the dynamic nature of the field and the collaborative efforts to bring innovative treatments to market. Show Less Read more

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