Poliomyelitis - Pipeline Insight, 2024

This Poliomyelitis - Pipeline Insight, 2024,” report provides comprehensive insights about 15+ companies and 15+ pipeline drugs in Poliomyelitis pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Poliomyelitis Understanding

Poliomyelitis: Overview

Poliomyelitis (polio) is a viral disease that can range in severity from self-limiting disease to meningitis. In its most severe form, it may present as acute flaccid paralysis. Polio has the potential to severely damage motor neurons leading to a lifetime of muscular dysfunction or even death if the respiratory function is affected. To avoid such a disability, the vaccine must be administered as primary prevention.

Poliovirus, the virus causing both acute polio and PPS, is a member of the Picornaviridae family and species Enterovirus C. There are three serotypes of wild Poliovirus: Poliovirus 1, 2, and 3. Wild type 1 poliovirus was the primary cause of the majority of the world’s paralytic polio cases until vaccines became widespread. Wild types 2 and 3 are considered eradicated as of 2015.

Poliovirus is primarily spread via fecal-oral contamination, but oral-oral spread is also possible. Primary infection can lead to viral replication in oropharyngeal and gastrointestinal lymphatic tissues. Maximum viral excretion begins 2 to 3 days before symptoms start and continue for an additional one week. In up to 95% of cases, infections are non-paralytic, presenting as a flu-like illness. In approximately 5% of cases, pure motor paralysis can occur. The spread of the virus to the CNS is poorly understood. If this does occur, the virus may cause anterior horn neuronal death resulting in a physical exam consistent with intact sensation and pure motor deficits.

Poliomyelitis - Pipeline Insight, 2024 report outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Poliomyelitis pipeline landscape is provided which includes the disease overview and Poliomyelitis treatment guidelines. The assessment part of the report embraces, in depth Poliomyelitis commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Poliomyelitis collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence R&D Poliomyelitis. The therapies under development are focused on novel approaches to treat/improve Poliomyelitis.

Poliomyelitis Emerging Drugs

Diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine: Boryung Pharmaceutical
Boryung Pharmaceutical is developing a combination vaccine for prophylaxis of diphtheria, tetanus, acellular pertussis and inactivated poliovirus (DTaP-IPV). Currently the product is in Phase III for the prevention of Poliomyelitis.

Poliomyelitis: Therapeutic Assessment

This segment of the report provides insights about the Poliomyelitis drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Poliomyelitis

There are approx. 15+ key companies which are developing the therapies Poliomyelitis. The companies which have their Poliomyelitis drug candidates in the most advanced stage, i.e phase III include KM Biologics

Phases

This report covers around 15+ products under different phases of clinical development like

• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration

Poliomyelitis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Oral
• Intravenous
• Subcutaneous

Molecule Type

Products have been categorized under various Molecule types such as

• Small molecule
• Cell Therapy
• Peptides
• Polymer
• Small molecule
• Gene therapy

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Poliomyelitis: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Poliomyelitis therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Poliomyelitis drugs.

Poliomyelitis Report Insights

• Poliomyelitis Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Poliomyelitis Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

• How many companies are developing Poliomyelitis drugs?
• How many Poliomyelitis drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Poliomyelitis?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Poliomyelitis therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Poliomyelitis and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• KM Biologics
• LG Chem
• Boryung Pharmaceutical
• Mitsubishi Tanabe Pharma Corporation
• Collaborations Pharmaceuticals
• Tianjin Can SinoBiotechnology
• Serum Institute of India
• Grifols

Key Products

• Hib-DTaP-poliovirus vaccine
• DTP-HepB-IPV-Hib vaccine
• Diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine
• DPT-IPV-Hib vaccine
• CSB 017
• SIIPL Tdap IPV
• Immune globulin
• DTwP-HepB-IPV-Hib vaccine

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