Drug Summary
KEVZARA (Sarilumab) is a fully human anti-IL-6R monoclonal IgG1 antibody that binds to both membrane bound and soluble interleukin-6 (IL-6) receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. This results in reduction of the effects of a substance in the body that can cause inflammation. KEVZARA is used to treat moderate to severe Rheumatoid Arthritis (RA) in adults. It is sometimes given together with other arthritis medicines. KEVZARA is usually given after other medications have been tried without successful treatment of symptoms. Mechanism of Action
Sarilumab binds to both soluble and membrane-bound IL-6 receptors (sIL-6R and mIL-6R) and has been shown to inhibit IL-6-mediated signaling through these receptors. IL-6 is a pleiotropic pro-inflammatory cytokine produced by a variety of cell types, including T- and B-cells, lymphocytes, monocytes, and fibroblasts. IL-6 has been shown to be involved in diverse physiological processes such as T-cell activation, induction of immunoglobulin secretion, initiation of hepatic acute phase protein synthesis, and stimulation of hematopoietic precursor cell proliferation and differentiation. IL-6 is also produced by synovial and endothelial cells, leading to local production of IL-6 in joints affected by inflammatory processes such as RA.
Scope of the Report
The report provides insights into:
- A comprehensive product overview including the KEVZARA description, mechanism of action, dosage and administration, research and development activities in Rheumatoid Arthritis.
- Elaborated details on KEVZARA regulatory milestones and other development activities have been provided in this report.
- The report also highlights the KEVZARA research and development activity in Rheumatoid Arthritis details across the United States, Europe and Japan.
- The report also covers the patents information with expiry timeline around KEVZARA.
- The report contains forecasted sales of KEVZARA for Rheumatoid Arthritis till 2032.
- Comprehensive coverage of the late-stage emerging therapies for Rheumatoid Arthritis.
- The report also features the SWOT analysis with analyst views for KEVZARA in Rheumatoid Arthritis.
Methodology
The report is built using data and information sourced primarily from internal databases, primary and secondary research and in-house analysis by the research team of industry experts. Information and data from the secondary sources have been obtained from various printable and nonprintable sources like search engines, news websites, global regulatory authorities websites, trade journals, white papers, magazines, books, trade associations, industry associations, industry portals and access to available databases.KEVZARA Analytical Perspective
In-depth KEVZARA Market Assessment
This report provides a detailed market assessment of KEVZARA in Rheumatoid Arthritis in the 7MM, i.e., United States, EU4 and the United Kingdom, and Japan. This segment of the report provides forecasted sales data from 2023 to 2032.KEVZARA Clinical Assessment
The report provides the clinical trials information of KEVZARA for Rheumatoid Arthritis covering trial interventions, trial conditions, trial status, start and completion dates.Report Highlights
- In the coming years, the market scenario for Rheumatoid Arthritis is set to change due to the extensive research and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
- The companies are developing therapies that focus on novel approaches to treat/improve the disease condition, assess challenges, and seek opportunities that could influence KEVZARA dominance.
- Other emerging products for Rheumatoid Arthritis are expected to give tough market competition to KEVZARA and launch of late-stage emerging therapies in the near future will significantly impact the market.
- A detailed description of regulatory milestones, and developmental activities, provide the current development scenario of KEVZARA in Rheumatoid Arthritis.
- This in-depth analysis of the forecasted sales data of KEVZARA from 2023 to 2032 will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the KEVZARA in Rheumatoid Arthritis.
Key Questions Answered
- What is the product type, route of administration and mechanism of action of KEVZARA?
- What is the clinical trial status of the study related to KEVZARA in Rheumatoid Arthritis and study completion date?
- What are the key collaborations, mergers and acquisitions, licensing and other activities related to the KEVZARA development?
- What are the key designations that have been granted to KEVZARA for Rheumatoid Arthritis?
- What is the forecasted market scenario of KEVZARA for Rheumatoid Arthritis?
- What are the forecasted sales of KEVZARA in the 7MM, including the United States, Europe, and Japan?
- What are the other emerging products available in Rheumatoid Arthritis and how are they giving competition to KEVZARA for Rheumatoid Arthritis?
- Which are the late-stage emerging therapies under development for the treatment of Rheumatoid Arthritis?
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Table of Contents
1. Report Introduction2. KEVZARA Overview in Rheumatoid Arthritis
2.1 Product Detail
2.2 Clinical Development
2.2.1 Clinical Studies
2.2.2 Clinical Trials Information
2.2.3 Safety and Efficacy
2.3 Regulatory milestones
2.4 Other Development Activities
2.5 Product Profile
3. Competitive Landscape (Marketed Therapies)
4. Competitive Landscape (Late-stage Emerging Therapies)*
5. KEVZARA Market Assessment
5.1 Market Outlook of KEVZARA in Rheumatoid Arthritis
5.2 7MM Market Analysis
5.2.1 Market Size of KEVZARA in the 7MM for Rheumatoid Arthritis
5.3 Country-wise Market Analysis
5.3.1 Market Size of KEVZARA in the United States for Rheumatoid Arthritis
5.3.2 Market Size of KEVZARA in Germany for Rheumatoid Arthritis
5.3.3 Market Size of KEVZARA in France for Rheumatoid Arthritis
5.3.4 Market Size of KEVZARA in Italy for Rheumatoid Arthritis
5.3.5 Market Size of KEVZARA in Spain for Rheumatoid Arthritis
5.3.6 Market Size of KEVZARA in the United Kingdom for Rheumatoid Arthritis
5.3.7 Market Size of KEVZARA in Japan for Rheumatoid Arthritis
6. SWOT Analysis
7. Analysts’ Views
8. Appendix
8.1 Bibliography
8.2 Report Methodology
9. Publisher Capabilities
10. Disclaimer
11. About the Publisher
12. Report Purchase Option
List of Tables
Table 1: KEVZARA, Clinical Trial Description, 2022
Table 2: KEVZARA : General Description
Table 3: Competitive Landscape (Marketed Therapies)
Table 4: Competitive Landscape (Emerging Therapies)
Table 5:KEVZARA Market Size in the 7MM, in USD million (2019-2032)
Table 6:KEVZARA Market Size in the United States, in USD million (2019-2032)
Table 7:KEVZARA Market Size in Germany, in USD million (2019-2032)
Table 8:KEVZARA Market Size in France, in USD million (2019-2032)
Table 9:KEVZARA Market Size in Italy, in USD million (2019-2032)
Table 10:KEVZARA Market Size in Spain, in USD million (2019-2032)
Table 11:KEVZARA Market Size in the United Kingdom, in USD million (2019-2032)
Table 12:KEVZARA Market Size in Japan, in USD million (2019-2032)
List of Figures
Figure 1: Market Size of KEVZARA in the 7MM, in USD million (2019-2032)
Figure 2: Market Size of KEVZARA in the United States, in USD million (2019-2032)
Figure 3: Market Size of KEVZARA in Germany, in USD million (2019-2032)
Figure 4: Market Size of KEVZARA in France, in USD million (2019-2032)
Figure 5: Market Size of KEVZARA in Italy, in USD million (2019-2032)
Figure 6: Market Size of KEVZARA in Spain, in USD million (2019-2032)
Figure 7: Market Size of KEVZARA in the United Kingdom, in USD million (2019-2032)
Figure 8: Market Size of KEVZARA in Japan, in USD million (2019-2032)