Serine Proteases Market Report 2026

The serine proteases market size has grown rapidly in recent years. It will grow from $2.49 billion in 2025 to $2.75 billion in 2026 at a compound annual growth rate (CAGR) of 10.7%. The growth in the historic period can be attributed to advancements in enzyme research, growth of pharmaceutical R&D, use in diagnostic testing, expansion of proteomics studies, demand for biological therapeutics.

The serine proteases market size is expected to see strong growth in the next few years. It will grow to $3.96 billion in 2030 at a compound annual growth rate (CAGR) of 9.5%. The growth in the forecast period can be attributed to growth of precision medicine, increasing autoimmune disease research, expansion of biologics manufacturing, advancements in recombinant technology, rising investment in life sciences. Major trends in the forecast period include rising use in therapeutic drug development, growing application in diagnostic assays, expansion of recombinant enzyme production, increasing research in complement system disorders, focus on high purity enzyme manufacturing.

The expansion of the food and beverage industry is expected to drive the growth of the serine proteases market in the coming years. The food and beverage industry includes all businesses involved in producing, processing, packaging, distributing, and selling food and drink products. The industry’s expansion is attributed to the rising global population, increased urban migration, and advancements in production, processing, and distribution aimed at improving efficiency. The use of serine proteases improves the quality, taste, and functionality of food and beverage products, supporting innovation and operational efficiency across the sector. For instance, in March 2023, according to Manitoba Agriculture, a Canada-based provincial government department, exports of processed food and beverage products from Manitoba rose to CAD 4.5 billion in 2023, marking a 9.5% increase compared to 2022. Therefore, the growth of the food and beverage industry is fueling the expansion of the serine proteases market.

Major companies operating in the serine protease market focus on developing innovative solutions, such as protease enzymes, to enhance drug efficacy, improve industrial processes, and create advanced formulations for personal care. This focus on innovation drives growth and addresses specific market needs across various industries. Protease enzymes are biological catalysts that break down proteins into smaller peptides or amino acids by cleaving peptide bonds. For instance, in May 2024, Biocatalysts Ltd., a UK-based biotechnology company, launched PromodTM 327L and PromodTM 295L, which are advanced protease enzymes that enhance the efficient hydrolysis of collagen into neutral-tasting, low molecular-weight peptides. Their benefits include improved flavor, faster processing times, and versatility across dietary supplements, cosmetics, and biomedical applications.

In March 2024, Novus International Inc., a US-based animal health and nutrition company, acquired BioResource International Inc. for an undisclosed amount. Through the acquisition, NOVUS will incorporate BRI's existing product range and gain control of its facilities in North Carolina, USA. BioResource International Inc. is a US-based provider of serine proteases.

Major companies operating in the serine proteases market are Thermo Fisher Scientific, Roche, Merck KGaA, Lonza, GenScript, Promega, R&D Systems, Sino Biological, New England Biolabs, Cayman Chemical, RayBiotech, Enzo Life Sciences, ProSpec-Tany TechnoGene, Bio‑Rad Laboratories, Inc., Takara Bio Inc., Abcam plc, Cell Signaling Technology, Inc., Sigma‑Aldrich Co. LLC, Amano Enzyme Inc., Advanced Enzyme Technologies Ltd., Biocatalysts Ltd., Novus Biologicals, ProteoChem, Inc.

Asia-Pacific was the largest region in the serine proteases market in 2025. The regions covered in the serine proteases market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the serine proteases market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The serine proteases market consists of sales of trypsin, chymotrypsin, thrombin, and elastase. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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