The Handbook of Glycomics provides the first comprehensive overview of the emerging field of glycomics, defined as the study of all complex carbohydrates in an organism or cell ("the glycome"). Beginning with analytic approaches and bioinformatics, this work provides a detailed discussion of relevant databases, data integration, and analysis. It then moves on to a discussion of specific model organism and pathogen glycomes followed by therapeutic approaches to human disorders of glycosylization. Structure and function of glycomes are included along with state-of-the-art technologies and systems approaches to the analysis of glycans.
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Table of Contents
Introduction to Glycomics
SECTION 1: Glycoconjugate Structural Analysis 1. Glycoproteomics: N-glycan Analysis 2. Glycoproteomics: O-glycan Analysis 3. Glycosaminoglycans 4. Isotopic Labeling of Glycans for Quantitative Glycomics SECTION II: Glycotranscriptomics 5. Glycotranscriptomics SECTION III: Protein-Glycan Interactions 6. Glycan Arrays 7. Chromatographic and Mass Spectrometric Techniques
SECTION IV: Glycobioinformatics
8. Integration of Glycomics Knowledge and Data
9. KEGG GLYCAN for integrated analysis of pathways, genes, and glycan structures
10. European Glycomics Portal SECTION V: Glycomes
11. Glycomics of the Immune System
12. Mouse and Human
13. Drosophila
14. Malaria
15. Parasitic Worms
SECTION VI: Disease Glycomes
16. Cancer Glycomics
17. An Introduction to Human Disorders of Glycosylation
18. Summary
