This book presents the most current scientific understanding behind most common pain disorders. Clinical scientists involved in pain science will gain a basic understanding of the causes of many types of pain and will be able to discuss various therapies with patients. Researchers new to pain science will gain an overall understanding of pain pathophysiology and targets for pain treatments. Covering every major aspect of pain science, from molecular and cellular pathways of pain to pain disorders and their treatments, Science of Pain bridges basic and clinical research like no other book on the topic. Edited by world-renowned pain scientist and Editor-in-Chief of the journal PAIN, Allan Basbaum, this book is an in-depth reference for basic and clinical scientists in pain research who must understand the basic science of pain, and help develop new treatment strategies for pain disorders.
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Table of Contents
Preface by Basbaum and Bushnell1 The Adequate Stimulus
R.D. Treede Johannes Gutenberg-University, Mainz, Germany
2 Pain Theories
F. Cervero McGill University, Montreal, QC, Canada
3 Anatomy of Nociceptors
S. Mense Institut f�r Anatomie und Zellbiologie, Universit�t Heidelberg, Heidelberg, Germany
4 Molecular Biology of the Nociceptor/Transduction
M.S. Gold University of Pittsburgh, Pittsburgh, PA, USA
5 Zoster-Associated Pain and Nociceptors
H. Maija Helsinki University Hospital, Helsinki, Finland
6 Ectopic Generators
M. Devor Hebrew University of Jerusalem, Jerusalem, Israel
7 Sodium Channels
John N. Wood University College London, London, UK
8 Physiology of Nociceptors
M. Ringkamp Johns Hopkins University, Baltimore, MD, USA
9 Itch
E. Carstens University of California, Davis, CA, USA
10 Thermal Sensation (Cold and Heat) through Thermosensitive TRP Channel Activation
Makoto Tominaga National Institutes of Natural Sciences, Okazaki, Japan
11 The Development of Nociceptive Systems
G.J. Hathway University College London, London, UK
12 Appropriate/Inappropriate Developed Pain Paths
J. Schouenborg Lund University, Lund, Sweden
13 Pain Control: A Child-Centered Approach
Patricia A. McGrath The University of Toronto, Toronto, ON, Canada
14 Assaying Pain-Related Genes: Preclinical and Clinical Correlates
V.E. Scott Global Pharmaceutical Research and Development, Abbott Park, IL, USA
15 Evolutionary Aspects of Pain
E.T. Walters University of Texas at Houston, Medical School, Houston, TX, USA
16 Redheads and Pain
J.S. Mogil McGill University, Montreal, QC, Canada
17 Autonomic Nervous System and Pain
W. J�nig Physiologisches Institut, Christian-Albrechts-Universit�t zu Kiel, Germany
18 Sympathetic Blocks for Pain
Sharma Columbia University, New York, NY, USA
19 Sprouting in Dorsal Root Ganglia
E.M. McLachlan Prince of Wales Medical Research Institute, Randwick, NSW, Australia
20 Vagal Afferent Neurons and Pain
W. J�nig Christian-Albrechts-Universit�t zu Kiel, Kiel, Germany
21 Sex, Gender, and Pain
R.B. Fillingim University of Florida College of Dentistry, Community Dentistry and Behavioral Science Gainesville, FL, USA
22 Neurotrophins and Pain
Lorne M. Mendell State University of New York, Stony Brook, NY, USA
23 Morphological and Neurochemical Organization of the Spinal Dorsal Horn
A. Ribeiro-da-Silva McGill University, Montreal, QC, Canada
24 Spinal Cord Physiology of Nociception
A.R. Light University of Utah, Salt Lake City, UT, USA
25 What is a Wide-Dynamic-Range Cell
D. Le Bars INSERM U-713, Paris, France
26 Spinal Cord Mechanisms of Hyperalgesia and Allodynia
T.J. Coderre McGill University, Montreal, QC, Canada
27 Glycine Receptors
H.U. Zeilhofer University of Zurich, Zurich, Switzerland
28 Pain Following Spinal Cord Injury
R.P. Yezierski Comprehensive Center for Pain Research and The McKnight Brain Institute, University of Florida, Gainesville, FL, USA
29 Long-Term Potentiation in Pain Pathways
J. Sandk�hler Medical University of Vienna, Vienna, Austria
30 Immune System, Pain and Analgesia
H.L. Rittner Charit� ? Universit�tsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
31 Mechanisms of Glial Activation after Nerve Injury
L.R. Watkins University of Colorado at Boulder, Boulder, CO, USA
32 Trigeminal Mechanisms of Nociception: Peripheral and Brainstem Organization
D.A. Bereiter University of Minnesota, Minneapolis, MN, USA
33 Migraine ? A Disorder Involving Trigeminal Brainstem Mechanisms
P.J. Goadsby University of California, San Francisco, CA, USA
34 Tooth Pain
M.R. Byers University of Washington, Seattle, WA, USA
35 Ascending Pathways: Anatomy and Physiology
D. Lima Universidade do Porto, Porto, Portugal
36 Dorsal Columns and Visceral Pain
W.D. Willis Jr. University of Texas Medical Branch, Galveston, TX, USA
37 Visceral Pain
G.F. Gebhart University of Pittsburgh, Pittsburgh, PA, USA
38 Irritable Bowel Syndrome
S. Bradesi University of California, Los Angeles, CA, USA
39 Pain in Childbirth
U. Wesselmann The Johns Hopkins University School of Medicine, Baltimore, MD, USA
40 Urothelium as a Pain Organ
L.A. Birder University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
41 The Brainstem and Nociceptive Modulation
M.M. Heinricher Oregon Health science University, Portland, OR, USA
42 Emotional and Behavioral Significance of the Pain Signal and the Role of the Midbrain Periaqueductal Gray (PAG)
K. Keay University of Sydney, Sydney, NSW, Australia
43 The Thalamus and Nociceptive Processing
J.O. Dostrovsky University of Toronto, Toronto, ON, Canada
44 Psychophysics of Sensations Evoked by Stimulation of the Human Central Nervous System
S. Ohara Johns Hopkins Hospital, Baltimore, MD, USA
45 Nociceptive Processing in the Cerebral Cortex
R.D. Treede Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
46 Phantom Limb Pai
H. Flor Central Institute of Mental Health, Mannheim, Germany
47 Human Insular Recording and Stimulation
F. Maugui�re Lyon I University and INSERM U879, Bron, France
48 The Rostral Agranular Insular Cortex
L. Jasmin Neurosurgery and Gene Therapeutics Research Institute, Los Angeles, CA, USA
49 Descending Control Mechanisms
K. Ren University of Maryland, Baltimore, MD, USA
50 Diffuse Noxious Inhibitory Controls (DNIC)
D. Le Bars INSERM U-713, Paris, France
51 Fibromyalgia
R. Staud University of Florida, Gainesville, FL, USA
52 Pain Perception ? Nociception during Sleep
G.J. Lavigne Universit� de Montr�al, Montreal, QC, Canada
53 Pharmacological Modulation of Pain
A. Dray AstraZeneca Research and Development, Montreal, PQ, Canada
54 Forebrain Opiates
J.-K. Zubieta University of Michigan, Ann Arbor, MI, USA
55 Neuropathic Pain: Basic Mechanisms (Animal)
M.H. Ossipov University of Arizona, Tucson, AZ, USA
56 Animal Models and Neuropathic Pain
I. Decosterd University of Lausanne, Lausanne, Switzerland
57 Neuropathic Pain: Clinical
R. Baron Christian-Albrechts-Universit�t Kiel, Kiel, Germany
58 Neurogenic Inflammation in Complex Regional Pain Syndrome (CRPS)
F. Birklein University of Mainz, Mainz, Germany
59 Complex Regional Pain Syndromes
R. Baron Christian-Albrechts-Universit�t Kiel, Kiel, Germany
60 Poststroke Pain
T.S. Jensen Aarhus University Hospital, Aarhus, Denmark
61 Psychophysics of Pain
R.H. Gracely University of Michigan Health System, VAMC, Ann Arbor, MI, USA
62 Consciousness and Pain
M. Devor Hebrew University of Jerusalem, Jerusalem, Israel
63 Assessing Pain in Animals
S.W.G. Derbyshire University of Birmingham, Birmingham, UK
64 Psychological Modulation of Pain
D.D. Price University of Florida, Gainesville, FL, USA
65 The Placebo Effect
F. Benedetti University of Turin Medical School, Turin, Italy
66 Hypnotic Analgesia
P. Rainville Universit� de Montr�al, Montreal, QC, Canada
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