This latest volume in the Encyclopaedia of Sports Medicine series, published under the auspices of the International Olympic Committee, is a landmark contribution to our understanding of the role of genes and genetics in sport and other physical activities.
The book is designed to move readers from the basic science of genomics and genetics and the regulation of gene expression to thorough, clearly–written discussions of today s most important topics and latest research, including the genetics of complex performance phenotypes, the contributions of small animal research, family and twin studies, and ethnic comparisons. A final section addresses how specific genes and molecular markers impact endurance, strength and power, and responsiveness to specific conditioning programs.
Authored by scientists whose work represents the leading edge in this rapidly–evolving field, Genetic and Molecular Aspects of Sports Performance is an essential new reference for exercise scientists, researchers in genetics and genomics, and sports medicine specialists.
Other Titles in the Series
Vol. I THE OLYMPIC BOOK OF SPORTS MEDICINE
Edited by A. Dirix, H.G. Knuttgen & K. Tittel
1988, ISBN 978 0 632 01963 2 (hardback)
Vol. II ENDURANCE IN SPORT
Edited by R.J. Shephard & P–O. Åstrand
2nd edition, 2000, ISBN 978 0 632 05348 3 (hardback)
Vol. III STRENGTH AND POWER IN SPORT
Edited by P.V. Komi
2nd edition, 2003, ISBN 978 0 632 05911 9 (hardback)
Vol. IV SPORTS INJURIES: BASIC PRINCIPLES OF PREVENTION AND CARE
Edited by P.A.F.H. Renström
1993, ISBN 978 0 632 03331 7 (hardback)
Vol. V CLINICAL PRACTICE OF SPORTS INJURY PREVENTION AND CARE
Edited by P.A.F.H. Renström
1994, ISBN 978 0 632 03785 8 (hardback)
Vol. VI THE CHILD AND ADOLESCENT ATHLETE
Edited by O. Bar–Or
1996, ISBN 978 0 865 42904 8 (hardback)
Vol. VII NUTRITION IN SPORT
Edited by R.J. Maughan
2000, ISBN 978 0 632 05094 9 (hardback)
Vol. VIII WOMEN IN SPORT
Edited by B.L. Drinkwater
2000, ISBN 978 0 632 05084 0 (hardback)
Vol. IX BIOMECHANICS IN SPORT
Edited by V. Zatsiorsky
2000, ISBN 978 0 632 05392 6 (hardback)
Vol. X REHABILITATION OF SPORTS INJURIES: SCIENTIFIC BASIS
Edited by W.R. Frontera
2003, ISBN 978 0 632 05813 6 (hardback)
Vol. XI THE ENDOCRINE SYSTEM IN SPORTS AND EXERCISE
Edited by W.J. Kraemer & A.D. Rogol
2005, ISBN 978 1 4051 3017 2 (hardback)
Vol. XII TENDINOPATHY IN ATHLETES
Edited by Savio L–Y. Woo, Per A.F.H. Renstrom & Steven P. Arnoczky
2007, ISBN 978 1 4051 5670 7 (hardback)
Vol. XIII THE YOUNG ATHLETE
Edited by H. Hebestreit & O. Bar–Or
2007, ISBN 978 1 4051 5647 9 (hardback)
Vol. XIV THE OLYMPIC TEXTBOOK OF MEDICINE IN SPORT
Edited by M. Schwellnus
2008, ISBN 9781405156370 (hardback)
Vol XV THE OLYMPICTEXTBOOK OF SCIENCE IN SPORT
Edited by R. Maughan
2008, ISBN 9781405156387 (hardback)
Vol XVI EPIDEMIOLOGY OF INJURY IN OLYMPIC SPORTS
Edited by Dennis Caine, Peter Harmer and Melissa Schiff
2010. ISBN 9781405173643 (hardback)
Vol XVII Neuromuscular Aspects of Sport Performance
Edited by P. Komi
2011. ISBN 9781444334470 (hardback)
Table of Contents
List of Contributors.Foreword.
Preface.
Part 1 The Science of Genomics and Genetics.
1 The Human Genome and Epigenome (john j. mulvihill, klaas j. wierenga and chad m. kerksick).
2 Mitochondrial Medicine in Health and Disease: Interface Between Athletic Performance and Therapeutics (douglas c. wallace).
3 Characterizing the Extent of Human Genetic Variation for Performance–Related Traits (john blangero and jack w. kent jr.).
4 Current Proteome Profiling Methods (yetrib hathout, catherine a. formolo, kristy j. brown and javad nazarian).
5 Bioinformatics and Public Access Resources (yue wang, huai li, david j. miller and jianhua xuan).
6 Search for Genes Influencing Complex Traits (corneliu henegar, henri hooton and karine clément).
Part 2 Evidence from Genetic Epidemiology Studies.
7 Genetic Epidemiology, Physical Activity, and Inactivity (molly s. bray, janet e. fulton, nishan sudheera kalupahana and j. timothy lightfoot).
8 Role of Genetics Factors in Sport Performance: Evidence from Family Studies (louis pérusse).
9 Twin Studies in Sport Performance (gaston p. beunen, maarten w. peeters and robert m. malina).
10 Twin and Family Studies of Training Responses (mark a. sarzynski, tuomo rankinen and claude bouchard).
11 Ethnic Differences in Sport Performance (yannis p. pitsiladis).
12 Selection Experiments in Rodents to Define the Complexity and Diversity of Endurance Capacity (steven l. britton and lauren gerard koch).
Part 3 Contributions of Specific Genes and Markers.
13 Genes and Endurance Performance (bernd wolfarth).
14 Genes and Strength and Power Phenotypes (martine a.i. thomis).
15 Genes and Response to Training (tuomo rankinen, mark a. sarzynski and claude bouchard).
16 Genetic Determinants of Exercise Performance: Evidence from Transgenic and Null Mouse Models (eunhee chung and leslie a. leinwand).
17 The ACE Gene and Performance (james r.a. skipworth, zudin a. puthucheary, jai rawal and hugh e. montgomery).
18 The ACTN3 Gene and Human Performance (daniel g. macarthur and kathryn n. north).
19 Mitochondrial DNA Sequence Variation and Performance (shinya kuno, hirofumi zempo and haruka murakami).
20 Genes, Exercise, and Lipid Metabolism (yohan bossé).
21 Genes, Exercise, and Glucose and Insulin Metabolism (leonidas g. karagounis and john a. hawley).
22 Genes, Exercise, and Cardiovascular Phenotypes (james m. hagberg).
23 Genes, Exercise, and Protein Metabolism (mark a. tarnopolsky).
24 The Regulation of Physical Activity by Genetic Mechanisms: Is There a Drive to Be Active? (nishan sudheera kalupahana, naima moustaid–moussa, jung han kim, brynn h. voy, david bassett, molly s. bray and j. timothy lightfoot).
25 Genes, Exercise, and Psychological Factors (eco j.c. de geus and marleen h.m. de moor).
Part 4 Systems Biology of Exercise and Training.
26 A Primer on Systems Biology, as Applied to Exercise Physiology and Metabolism (james a. timmons and jorn w. helge).
27 Systems Biology Through Time Series Data A Strength of Muscle Remodeling (monica hubal, zuyi wang and
eric p. hoffman).
28 Proteomics in Exercise Training Research (dustin s. hittel).
29 The Influence of Physical Exercise on Adult Stem Cells (fawzi kadi).
Part 5 Ethical and Societal Implications.
30 Genetics and Ethics in Elite Sport (sigmund loland).
31 Genes and Talent Selection (stephen m. roth).
32 Performance Enhancement by Gene Doping (anna baoutina).
33 Bioethical Concerns in a Culture of Human Enhancement (andy miah).
Index.
