One of the key challenges current biomaterials researchers face is identifying which of the dizzying number of highly specialized characterization tools can be gainfully applied to different materials and biomedical devices. Since this diverse marketplace of tools and techniques can be used for numerous applications, choosing the proper characterization tool is highly important, saving both time and resources.
Characterization of Biomaterials is a detailed and multidisciplinary discussion of the physical, chemical, mechanical, surface, in vitro and in vivo characterization tools and techniques of increasing importance to fundamental biomaterials research.
Characterization of Biomaterials will serve as a comprehensive resource for biomaterials researchers requiring detailed information on physical, chemical, mechanical, surface, and in vitro or in vivo characterization. The book is designed for materials scientists, bioengineers, biologists, clinicians and biomedical device researchers seeking input on planning on how to test their novel materials, structures or biomedical devices to a specific application. Chapters are developed considering the need for industrial researchers as well as academics.
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Table of Contents
Chapter 1. Introduction to Biomaterials
- Natural and synthetic biomaterials an introduction
- Applications of biomaterials
- A few case studies related to failures of biomaterials and its impact focus on need for appropriate characterization of biomaterials
Chapter 2: Physical and Chemical Characterization of Biomaterials
- Physical properties of biomaterials an introduction
- Microstructural characterization of biomaterials
- Phase changes in biomaterials this part will focus on understanding phase change behavior and their measurement techniques in various materials like NiTi type shape memory alloys for stents or calcium phosphate ceramics and their phase change as a function of temperature, pH and so on.
- Porous biomaterials Different types of porosity and their impact on biomaterials.
- Structural characterization of biomaterials focus will be on different techniques such as IR, NMR, and other spectroscopic analysis.
Chapter 3. Mechanical Characterization of Biomaterials
- Mechanical properties of biomaterials an introduction
- Uniaxial deformation in biomaterials
- Multiaxial such as biaxial and bending/flexural deformation in biomaterials
- Cyclic deformation in biomaterials
- Rotating bending fatigue
- Tension-tension, tension-compression and compression-compression fatigue
Chapter 4. Surface Characterization of Biomaterials
- Surface properties of biomaterials an introduction
- Surface chemistry, surface roughness, wetting and surface energy
- Hardness measurements macro, micro and nano-indentations
- Adhesion and interfacial strengths of coatings
- Surface degradation of biomaterials
Chapter 5. In vitro Characterization of Biomaterials I
- Cell-materials interactions on biomaterials an introduction
- Cytocompatibility assessment
- Measurements of cell adhesion, proliferation and differentiation of cell-materials interactions
- Immunochemistry and protein assays
- Anti-microbial characterization of materials
Chapter 6. In vivo Characterization of Biomaterials II
- Tissue materials interactions with biomaterials an introduction
- Biocompatibility studies
- Tissue materials interactions Histology and histomorphometric analysis
- Biodistribution studies
- Tissue integration and bio-mechanical analysis
Chapter 7. Characterization of Biomedical Devices
- Device level testing vs. materials analysis an introduction
- Case studies a few selected case studies will be presented towards device level characterization such as
- Wear behavior of articulating surfaces in biomaterials
Authors
Amit Bandyopadhyay School of Mechanical and Materials Engineering, Washington State University Pullman, WA, USA.Prof. Bandyopadhyay is Herman and Brita Lindholm Endowed Chair Professor at the School of Mechanical and Materials Engineering, Washington State University (WSU), also a Fellow of the National Academy of Inventors (NAI), American Ceramic Society (ACerS), American Society for Materials (ASM International), American Institute for Medical and Biological Engineering (AIMBE) and American Association for the Advancement of Science (AAAS). He has published over 250 technical papers including over 170 journal papers. He holds 11 US patents and several patent applications are currently pending at the United States Patent and Trademark Office. He has edited 8 books.His research expertise lies with additive manufacturing of metallic and ceramic materials and their composites towards structural, bio- and piezoelectric materials.
Susmita Bose School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, USA.
Susmita Bose is a Professor in the School of Mechanical and Materials Engineering,
an affiliate professor in the Department of Chemistry at Washington State University
(WSU). In 2004, Dr. Bose received the prestigious Presidential Early Career Award for
Scientist and Engineers (PECASE, the highest honor given to a young scientist by the US
President at the White House) award from the National Science Foundation. Dr. Bose was
named as a "Kavli fellow? by the National Academy of Sciences. In 2009, she received the
prestigious Schwartzwalder-Professional Achievement in Ceramic Engineering (PACE)
Award, and in 2014 Richard M. Fulrath Award, which is an international award given to one
academician in the US annually (below age 45), from the American Ceramic Society. Dr. Bose is
editorial board member for several international journals, including Acta Biomaterialia
, Journal of the American Ceramic Society, Journal of Materials Chemistry B, International Journal of
Nanomedicine and Additive Manufacturing. Dr. Bose has published over 200 technical papers
with ~ 5000 citations, "h? index 40. Dr. Bose is a fellow of the American Institute for Medical and
Biological Engineering (AIMBE) and the American Ceramic Society (ACerS).
