Building on the success of the previous edition, this extremely thorough revision:
- features a new section on Guidelines for Liver Tumors, where you will find specific strategies for treating common liver malignancies; the guidelines were prepared by the Associate Editors and take into account national and international society guidelines
- reflects actual practice by taking a multidisciplinary approach, with contributions from international experts who have extensive experience with this patient population
- achieves comprehensive and balanced coverage by having each chapter reviewed by the Editor, Deputy Editor, two Associate Editors, and at least one external reviewer
- includes 16 new chapters that cover liver anatomy, histologic changes in the liver, epidemiology and natural history of HCC, CCC and colorectal liver metastases, strategies of liver resection, and economic aspects as well as novel therapies
- facilitates the kind of daily interaction among hepatologists, hepatic surgeons, medical oncologists, radiotherapists, and interventional radiologists that is essential when treating patients with complex liver malignancies
In 44 chapters organized into six major sections, the book covers the full range of liver tumors. The perfect blend of evidence and experience, Malignant Liver Tumors: Current and Emerging Therapies, 3rd Edition, illuminates the path to better patient care.
Table of Contents
Contributors, viiPreface, xi
Acknowledgments, xiii
Abbreviations, xiv
Section 1 Introduction, 1
1 From Promethean to Modern Times, 3
Kuno Lehmann, Stefan Breitenstein, and Pierre-Alain Clavien
2 Hepatic Anatomy and Terminology, 11
Steven M. Strasberg
Section 2 Epidemiology and Diagnosis, 27
Introduction, 29
Chung-Mau Lo
3 Histology and Pathology of Normal and Diseased Liver, 30
Valérie Paradis and Achim Weber
4 Pathology of Primary and Secondary Malignant Liver Tumors, 40
Kay Washington
5 Epidemiology, Etiology, and Natural History of Hepatocellular Carcinoma, 52
Wei-Chen Lee and Miin-Fu Chen
6 Epidemiology, Etiology, and Natural History of Cholangiocarcinoma, 56
Peter Neuhaus, Ulf P. Neumann, and Daniel Seehofer
7 Epidemiology, Etiology, and Natural History of Colorectal Liver Metastases, 64
Robert J. Porte
8 Tumor Markers in Primary and Secondary Liver Tumors, 69
Ketsia B. Pierre and Ravi S. Chari
9 Modalities for Imaging Liver Tumors, 76
Dominik Weishaupt and Thomas F. Hany
Section 3 Systemic and Regional Therapies, 103
Introduction, 105
Ravi S. Chari
10 Systemic Treatment of Hepatobiliary Tumors, 107
Panagiotis Samaras, Michael A. Morse, and Bernhard C. Pestalozzi
11 External Beam Radiation Therapy for Liver Tumors, 122
Rakesh Reddy and A. Bapsi Chakravarthy
12 Internal Radiation Therapy for Liver Tumors, 131
Ahsun Riaz, Laura Kulik, Michael Abecassis, and Riad Salem
13 Transarterial Embolization for Patients with Hepatocellular Carcinoma, 139
Jordi Bruix, Carmen Ayuso, and Maria I. Real
14 Selective Continuous Intra-arterial Chemotherapy for Liver Tumors, 151
Fidel D. Huitzil-Melendez, Stefan Breitenstein, and Nancy Kemeny
15 Isolated Hepatic Perfusion and Percutaneous Hepatic Perfusion, 164
Charles K. Heller, III, James F. Pingpank, and Steven K. Libutti
Section 4 Resection, Ablation or Transplantation for Liver Tumors, 173
Introduction, 175
Jean-Nicolas Vauthey and Tadatoshi Takayama
16 Liver Resection of Primary Tumors: Hepatocellular Carcinoma, Cholangiocarcinoma, and Gallbladder Cancer, 177
Tadatoshi Takayama and Masatoshi Makuuchi
17 Liver Resection of Colorectal Liver Metastases, 192
Daria Zorzi, Yun Shin Chun, and Jean-Nicolas Vauthey
18 Laparoscopic Liver Resection, 203
Luca Viganò and Daniel Cherqui
19 Repeat Resection for Liver Tumors, 216
Mickael Lesurtel and Henrik Petrowsky
20 Cryoablation of Liver Tumors, 227
Sivakumar Gananadha and David L. Morris
21 Thermal Ablation of Liver Tumors by Radiofrequency, Microwave, and Laser Therapy, 244
M. B. Majella Doyle and David C. Linehan
22 Ethanol and Other Percutaneous Injection Modalities in the Treatment of Liver Tumors, 266
Michael A. Heneghan and Andrew D. Yeoman
23 Transplantation for Liver Tumors, 281
François Durand, Claire Francoz, and Jacques Belghiti
24 Preventing Recurrence of Hepatocellular Carcinoma after Curative Resection, 296
Stefan Breitenstein, Dimitris Dimitroulis, and Beat Müllhaupt
Section 5 Guidelines for Liver Tumor Treatment, 305
Introduction, 307
Stefan Breitenstein and Pierre-Alain Clavien
25 Strategies for Safer Liver Surgery, 308
Philipp Dutkowski, Olivier de Rougemont, and Pierre-Alain Clavien
26 Hepatocellular Carcinoma, 317
Tadatoshi Takayama
27 Cholangiocarcinoma, 324
Jacques Belghiti and Charles B. Rosen
28 Gallbladder Cancer, 333
Juan Hepp and Chung-Mau Lo
29 Colorectal Liver Metastases, 342
Phuong L. Doan, Jean-Nicolas Vauthey, Martin Palavecino, and Michael A. Morse
Section 6 Emerging Therapies, 347
Introduction, 349
Michael A. Morse and Josep M. Llovet
30 Viral-Based Therapies for Primary and Secondary Liver Cancer, 352
Menghua Dai, Lorena Gonzalez, and Yuman Fong
31 Signaling Pathways and Rationale for Molecular Therapies in Hepatocellular Carcinoma, 368
Augusto Villanueva, Clara Alsinet, and Josep M. Llovet
32 Novel Therapies Targeted at Signal Transduction in Liver Tumors, 382
Fidel D. Huitzil-Melendez, Ghassan K. Abou-Alfa, and Michael A. Morse
33 Induction of Apoptosis in Liver Tumors, 393
Markus Selzner and Pierre-Alain Clavien
34 Antiangiogenic Agents for Liver Tumors, 400
Mathijs Vogten, Emile E. Voest, and Inne H.M. Borel Rinkes
35 Integrative Oncology: Alternative and Complementary Treatments, 414
Barrie R. Cassileth and Jyothirmai Gubili
Section 7 Special Tumors, Population, and Special Considerations, 421
Introduction, 423
Stefan Breitenstein and Pierre-Alain Clavien
36 Liver Metastases from Endocrine Tumors, 424
Clayton D. Knox and C. Wright Pinson
37 Uncommon Primary and Metastatic Liver Tumors, 439
Stefan Breitenstein, Ashraf Mohammad El-Badry, and Pierre-Alain Clavien
38 Liver Tumors in Special Populations, 454
Tadahiro Uemura, Akhtar Khan, and Zakiyah Kadry
39 Malignant Liver Tumors in Children, 475
Xavier Rogiers and Ruth De Bruyne
40 Liver Tumors in Asia, 487
Norihiro Kokudo, Sumihito Tamura, and Masatoshi Makuuchi
41 Liver Tumors in South America, 500
Lucas McCormack and Eduardo de Santibañes
42 Liver Tumors in Africa, 509
Michael C. Kew
43 Anesthetic Management of Liver Surgery, 519
Marco P. Zalunardo
44 Qualitative and Economic Aspects of Liver Surgery, 531
René Vonlanthen, Ksenija Slankamenac, and Christian Ernst
Index, 539
