A practical reference to the medical and surgical treatment of epilepsy
The third edition of The Treatment of Epilepsy has been thoroughly updated. It is a reference work, but has a strong practical bias, and is designed to assist neurologists, neurosurgeons and other clinicians at all levels who are involved in the treatment of patients with epilepsy. It is a definitive source of clinical information to guide clinical practice and rational therapy.
Written and edited by leading experts, many actively involved with the International League Against Epilepsy, this new edition:
- covers the recent advances in the principles and approaches to epilepsy therapy, the introduction of new drugs and the development of new surgical techniques
- contains 26 completely new chapters and 61 new contributors
- includes pharmacological properties and prescribing information for all drugs used in the treatment of epilepsy
- features the important contribution of a new editor Jerome Engel Jr, Professor of Neurology at the University of California School of Medicine in Los Angeles.
The third edition of The Treatment of Epilepsy has been thoroughly updated. It is a reference work, but has a strong practical bias, and is designed to assist neurologists, neurosurgeons and other clinicians at all levels who are involved in the treatment of patients with epilepsy. It is a definitive source of clinical information to guide clinical practice and rational therapy.
Written and edited by leading experts, many actively involved with the International League Against Epilepsy, this new edition:
- covers the recent advances in the principles and approaches to epilepsy therapy, the introduction of new drugs and the development of new surgical techniques
- contains 26 completely new chapters and 61 new contributors
- includes pharmacological properties and prescribing information for all drugs used in the treatment of epilepsy
- features the important contribution of a new editor Jerome Engel Jr, Professor of Neurology at the University of California School of Medicine in Los Angeles.
Table of Contents
Section 1 – Introduction1. Definitions and Classification of Epilepsy, Christina A. Gurnett and W. Edwin Dodson
2. Epidemiology and Prognosis of Epilepsy, Lars Forsgren and Dale Hesdroffer
3. Aetiology of Epilepsy, Simon D. Shorvon
4. Differential Diagnosis of Epilepsy, Mark Cook
5. Mechanisms of Epileptogenesis, Giuliano Avanzini and Silvana Franceschetti
6. Antiepileptic Drug Discovery, Steve H. White
7. Mechanisms of Antiepileptic Drug Action, Matthew C. Walker, Rainer Surges and A. Fisher
8. Mechanisms of Tolerance and Drug Resistance, Wolfgang Löscher and Dieter Schmidt
Section 2 – Principles of Medical Management
9. General Principles of Medical Management, Emilio Perucca
10. Management of Newly Diagnosed Epilepsy, Yvonne M. Hart
11. Management of Chronic Active Epilepsy in Adults, Simon D. Shorvon
12. Management of Epilepsy in Remission, Patrick Kwan and Howan Leung
13. Management of Epilepsy in Infants, Catherine Chiron
14. Management of Childhood Epilepsy Syndromes, Colin D. Ferrie
15. Management of Epilepsies Associated with Specific Diseases in Children, John H. Livingston
16. Management of Epilepsy in the Elderly, Hiba Arif, Anil Mendiratta and Lawrence J. Hirsch
17. Management of Epilepsy in People with Learning Disabilities, Eylert Brodtkorb
18. Emergency Treatment of Seizures and Status Epilepticus, Matthew C. Walker and Simon D. Shorvon
19. Traumatic Brain Injury and Other Risks, Marc Dichter and Nancy R. Temkin
20. Management of Medical Co-morbidity Associated with Epilepsy, Gagandeep Singh
21. Psychiatric Features of Epilepsy and their Management, Brent Elliott, Meriem Amarouche and Simon D. Shorvon
22. Management of Side-effects of Antiepileptic Drugs, Gaetano Zaccara, Fabrizio Balestrieri and Aldo Ragazzoni
23. Ketogenic Diets, Eric H. Kossoff and Jennifer L. Dorward
24. Non-pharmacological, Complementary and Alternative Treatments for Epilepsy, Tom Whitmarsh
25. Reproductive Aspects of Epilepsy Treatment, Torbjörn Tomson
26. Epilepsy Counselling, Anthony Linklater, Doreen Patsika and Susan Usiskin
27. Genetic Counselling in Epilepsy, Federico Zara
28. Drug Interactions, Edoardo Spina
29. Medical Treatment of Epilepsy in Situations with Limited Resources, Gretchen L. Birbeck
Section 3 – Antiepileptic Drugs
30. Introduction to the Choice of Antiepileptic Drugs, Emilio Perucca
31. Acetazolamide, Miri Y. Neufeld
32. Adrenocorticotropic Hormone and Corticosteroids, Federico Vigevano and M. R. Cilio
33. Benzodiazepines used Primarily for Chronic Treatment (Clobazam, Clonazepam, Clorazepate and Nitrazepam), Peter Camfield and Carol Camfield
34. Benzodiazepines used Primarily for Emergency Treatment (Diazepam, Lorazepam and Midazolam), Eugen Trinka
35. Brivaracetam, Philipp von Rosenstiel and Emilio Perucca
36. Carisbamate, Gerald P. Novak and Martin J. Brodie
37. Carbamazepine, Matti Sillanpää, Leena Haataja, T. Tomson and S.I. Johannessen
38. Eslicarbazepine Acetate, Patricio Soares-da-Silva, Luis Almeida and Meir Bialer
39. Ethosuximide, Tracy A. Glauser and Emilio Perucca
40. Felbamate, Ilo E. Leppik and J.R. White
41. Gabapentin, Ernest R. Somerville and Andrew W. Michell
42. Lacosamide, Rajesh Sachdeo
43. Lamotrigine, Fumisuke Matsuo and Awais Riaz
44. Levetiracetam, Jacqueline A. French and Francoise Tonner
45. Oxcarbazepine, Edward Faught and Nita Limdi
46. Phenobarbital, Primidone and Other Barbiturates, Roberto Michelucci, Elena Pasini and Carlo Alberto Tassinari
47. Phenytoin, Mervyn J. Eadie
48. Piracetam, Simon D. Shorvon
49. Pregabalin, Sylvain Rheims and Philippe Ryvlin
50. Retigabine, Harry Mansbach and Michel Baulac
51. Rufinamide, Victor Biton
52. Stiripentol, Kai Eriksson and Tapani Keränen
53. Tiagabine, Reetta Kälviäinen
54. Topiramate, J. Helen Cross and Kate J. Riney
55. Valproate, Blaise F.D. Bourgeois
56. Vigabatrin, Günter Krämer and Gabriele Wohlrab
57. Zonisamide, Stephen J. Wroe
58. Other Drugs Rarely Used, Hartmut Meierkord and M. Holtkamp
59. Antiepileptic Drugs in Early Clinical Development, Philip N. Patsalos and Josemir W. Sander
Section 4 – Presurgical Assessment and Epilepsy Surgery
60. Overview of Surgical Treatment for Epilepsy, Jerome Engel Jr
61. Scalp EEG in the Epilepsy Surgery Evaluation, John M. Stern and Christine M. Bower
62. Invasive EEG in Presurgical Evaluation of Epilepsy, Susan S. Spencer, Dang K. Nguyen and Robert B. Duckrow
63. MEG in Presurgical Evaluation of Epilepsy, Herman Stefan, S. Rampp and R. Hopfengärtner
64. MRI in the Presurgical Evaluation, Christian E. Elger and J. Wellmer
65. PET and SPECT in Presurgical Evaluation of Epilepsy, Wim Van Paesschen, Karolien Goffin and Koen Van Laere
66. Experimental Neurophysiological Techniques, François Mauguière, Isabelle Merlet and Julien Jung
67. Neuropsychological Testing in Presurgical Evaluation, Marilyn Jones-Gotman and Jelena Djordjevic
68. Presurgical Psychiatric Evaluation, Andres M. Kanner
69. Mesial Temporal Lobe Surgery and Other Lobar Resections, James Leiphart and Itzhak Fried
70. Resective Surgery of Neoplasms, N.M. Wetjen, Mithri R. Junna, K. Radhakrishnan, A.A. Cohen-Gadol and Gregory D. Cascino
71. Resective Surgery of Vascular and Infective Lesions for Epilepsy, Christopher E. Uff and Neil D. Kitchen
72. Surgery of Developmental Anomalies Causing Epilepsy, Youssef G. Comair and Joshua Chern
73. Hemispherectomy for Epilepsy, Olivier Delalande, Georg Dorfmüller, and Christine Bulteau
74. Corpus Callosotomy, David W. Roberts
75. Hypothalamic Hamartoma and Multiple Subpial Transection, Michael Smith, Rich Burne and Andres Kanner
76. Awake Surgery for Epilepsy, Christian B. Kaufman and Webster H. Pilcher
77. Epilepsy Surgery in Children, Jason S. Hauptman and Gary W. Mathern
78. Stereotactic Surgery for Epilepsy, Andrew W. McEvoy and Fiona J.L. Arnold
79. Complications of Epilepsy Surgery, Charles E. Polkey
80. Anaesthesia for Epilepsy Surgery, Barbara Van de Wiele
81. Vagal Nerve Stimulation, Steven C. Schachter
82. Brain Stimulation, Gregory K. Bergey
83. Stereotactic Radiosurgery for Medically Intractable Epilepsy, Isaac Yang, Edward F. Chang and Nicholas M. Barbaro
84. Future Focal Treatment Approaches to Epilepsy, Hannah R. Cock and Karen E. Nilsen
85. Epilepsy Surgery in Countries with Limited Resources, Andre Palmini
