Table of Contents
Guide to Media Resources xvi
PART I INTRODUCTION AND BACKGROUND 1
1 Life 3
2 Aqueous Solutions 40
3 Thermodynamic Principles: A Review 52
PART II BIOMOLECULES 65
4 Amino Acids 67
5 Nucleic Acids, Gene Expression, and Recombinant DNA Technology 82
6 Techniques of Protein and Nucleic Acid Purifications 129
7 Covalent Structures of Proteins and Nucleic Acids 163
8 Three-Dimensional Structures of Proteins 221
9 Protein Folding, Dynamics, and Structural Evolution 278
10 Hemoglobin: Protein Function in Microcosm 323
11 Sugars and Polysaccharides 359
12 Lipids and Membranes 386
PART III MECHANISMS OF ENZYME ACTION 467
13 Introduction to Enzymes 469
14 Rates of Enzymatic Reactions 482
15 Enzymatic Catalysis 506
PART IV METABOLISM 557
16 Introduction to Metabolism 559
17 Glycolysis 593
18 Glycogen Metabolism 638
19 Signal Transduction 671
20 Transport through Membranes 744
21 Citric Acid Cycle 789
22 Electron Transport and Oxidative Phosphorylation 823
23 Other Pathways of Carbohydrate Metabolism 871
24 Photosynthesis 901
25 Lipid Metabolism 940
26 Amino Acid Metabolism 1019
27 Energy Metabolism: Integration and Organ Specialization 1088
28 Nucleotide Metabolism 1107
PART V EXPRESSION AND TRANSMISSION OF GENETIC INFORMATION 1143
29 Nucleic Acid Structures 1145
30 DNA Replication, Repair, and Recombination 1173
31 Transcription 1260
32 Translation 1338
33 Viruses: Paradigms for Cellular Function W-1
34 Eukaryotic Gene Expression W-53
35 Molecular Physiology W-165
(Chapters 33 35 are available on our website,
