Carbohydrates are ubiquitous, essential molecules, as important as nucleic acids and proteins yet less well understood. Mounting data demonstrate that microbial and mammalian glycans and their protein-binding partners (lectins) play central roles in all innate and adaptive immune responses. Indeed, programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. Glycobiology of the Immune Response explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system
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Table of Contents
Glycobiology of immune responses 1
Gabriel A. Rabinovich, Yvette van Kooyk and Brian A. Cobb
Multifarious roles of sialic acids in immunity 16
Ajit Varki and Pascal Gagneux
Siglecs as sensors of self in innate and adaptive immune responses 37
James C. Paulson, Matthew S. Macauley and Norihito Kawasaki
Interleukin-2, Interleukin-7, T cell-mediated autoimmunity, and N-glycosylation 49
Ari Grigorian, Haik Mkhikian and Michael Demetriou
T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival 58
Mary C. Clark and Linda G. Baum
Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells 68
Bo Pei, Jose Luis Vella, Dirk Zajonc and Mitchell Kronenberg
Gelectins in acute and chronic inflammation 80
Fu-Tong Liu, Ri-Yao Yang and Daniel K. Hsu
Mechanisms underlying in vivo polysaccharide-specific immunoglobulin responses to intact extracellular bacteria 92
Clifford M. Snapper
CD33-related siglecs as potential modulators of inflammatory responses 102
Paul R. Crocker, Sarah J. McMillan and Hannah E. Richards
Sulfated glycans control lymphocyte homing 112
Hiroto Kawashima and Minoru Fukuda
Acute phase glycoproteins: bystanders or participants in carcinogenesis? 122
Eugene Dempsey and Pauline M. Rudd
Glycans, galectins, and HIV-1 infection 133
Sachiko Sato, Michel Ouellet, Christian St-Pierre and Michel J. Tremblay
An evolutionary perspective on C-type lectins in infection and immunity 149
Linda M. van den Berg, Sonja I. Gringhuis and Teunis B. H. Geijtenbeck
Integrated approach toward the discovery of glycol-biomarkers of inflammation-related diseases 159
Takashi Angata, Reiko Fuijinawa, Ayako Kurimoto, Kazuki Nakajima, Masaki Kato, Shinji Takamatsu, Hiroaki Korekane, Cong-Xiao Gao, Kazuaki Ohtsubo, Shinobu Kitazume and Naoyuki Taniguchi
Novel roles for the IgG Fc Glycan 170
Robert M. Anthony, Fredrik Wermeling and Jeffrey V. Ravetch
The effect of galectins on leukocyte trafficking in inflammation: sweet or sour? 181
Dianne Cooper, Asif J. Iqbal, Beatrice R, Grittens, Carmela Cervone and Mauro Perretti
Engineering cellular trafficking via glycosyltransferase-programmed stereosubstitution 193
Robert Sackstein
The expanding role of α2-3 sialylation for leukocyte trafficking in vivo 201
Markus Sperandio
Beyond glycoproteins as galectin counterreceptors: effector T cell growth control of tumors via ganglioside GM1 206
Robert W. Ledeen, Gusheng Wu, Sabine André, David Bleich, Guillementte Huet, Herbert Kaltner, Jürgen Kopitz and Hans-Joachim Gabius
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Polarization of host immune responses by helminth-expressed glycans
Donald Harn Jr., Smanla Tundup and Leena Srivastava
Carbohydrate-recognition in the immune system: contributions of NGL-based microarrays to ligand discovery
Ten Feizi
Diversity in recognition of glycans by F-type lectins and galectins: molecular, structural, and biophysical aspects
Gerardo R. Vasta, Hafiz Ahmed, Mario A. Bianchet, José A. Fernández-Robledo and L. Mario Amzel
