Therapeutic options for late-stage liver cancer are very limited and the prognosis is often poor. A better understanding of the molecular mechanisms involved in the initiation, progression, and metastasis of hepatocellular carcinoma is critical for developing more rational diagnostic and therapeutic approaches.
This e-book covers current developments on clinically relevant research on the molecular biology of hepatocellular carcinoma. This e-book should be a valuable reference for professional gastroenterologists, hepatologists and oncologists as well as medical students and researchers.
This e-book covers current developments on clinically relevant research on the molecular biology of hepatocellular carcinoma. This e-book should be a valuable reference for professional gastroenterologists, hepatologists and oncologists as well as medical students and researchers.
Table of Contents
Foreword iPreface ii
List of Contributors iv
Acknowledgements vii
CHAPTERS
1 The Relationship between Liver Fibrosis and Hepatocellular Carcinoma 3
Hai Li and Ji-D. Jia
2 A Possible Link between Non-Alcoholic Steatohepatitis and Hepatocellular Cancer 8
Elisabetta Bugianesi and Federico Salamone
3 Viral Associated Hepatocellular Carcinoma 21
Alfred S.-L. Cheng and Henry L.-Y. Chan
4 Non-Viral Cause of Liver Cirrhosis: Do they Lead to Hepatocellular Carcinoma? 32
Yuan-W. Chen and Jian-G. Fan
5 Signaling Pathways Involved in Molecular Carcinogenesis of Hepatocellular Carcinoma 39
Tatsuo Kanda, Fumio Imazeki, Fumihiko Kanai, Motohisa Tada, Osamu Yokosuka and Masao Omata
6 MicroRNAs in Human Hepatocellular Carcinoma 56
Wilson K.C. Leung and Nathalie Wong
7 Characteristics of Liver Stem/Progenitor Cells and their Relation to Cancer: Response to
Inflammatory and Cell Death Signals
67
Cornelia S. Viebahn, Bernard Callus and George C.T. Yeoh
8 Aging and Hepatocellular Carcinoma: Possible Molecular Mechanisms 80
Aiping Tian, Liang Qiao and Xiang Yan
9 Molecular Mechanisms of Liver Cancer Metastasis 86
Maria L. Balmer and Jean-F. Dufour
10 Biomarkers for Diagnosis and Surveillance in Hepatocellular Carcinoma 106
Thomas Wex, Kerstin Schütte, Jan Bornschein and Peter Malfertheiner
11 Animal Models of Hepatocellular Carcinoma 116
Sarah L. Walker, Jacob George and Lionel W. Hebbard
12 Chemoprevention of Hepatocellular Carcinoma 129
Massimo Colombo
13 An Overview on Molecular Therapy for Hepatocellular Carcinoma 138
Quanda Liu, Yongning Zhou, Zenan Hu and Liang Qiao
14 Role of Angiogenesis in HCC Development and Therapy 149
Lionel W. Hebbard
15 Non-Surgical Management of Hepatocellular Carcinoma: Possible Mechanisms 162
Yumin Li, Wenting He, Tao Liu and Yingtai Chen
16 Treatment of Hepatocellular Carcinoma with Traditional Chinese Medicine: Possible Molecular
Mechanisms
167
Cai-Y. Zhao, Xiaoyu Liu, Chuan Shen, Yadong Wang and Liang Qiao
17 Randomised Controlled Trials in the Primary Treatment of Hepatocellular Carcinoma 174
Monica Robotin
Subject Index 196
