Table of Contents
Foreword iPreface ii
Contributors iii
1. INTRODUCTION
CHAPTER 1: Introduction to Supercritical Fluids: Basic Principles and Applications 1
M. Nunes da Ponte
2. PHARMACEUTICAL PROCESSING
CHAPTER 2: Applications of Supercritical Expansion Processes for Particle Formation 8
Ana Rita C. Duarte
CHAPTER 3: Supercritical Anti-Solvent Micronization: Control of Morphology and
Particle Size 16
Ernesto Reverchon, Iolanda De Marco
CHAPTER 4: Particles from Gas-Saturated Solutions and Related Methods for Particle
Engineering 29
A.R. Sampaio de Sousa, Catarina M.M. Duarte
CHAPTER 5: Fundamentals and Modeling of Supercritical Precipitation Processes 41
Ángel Martín, María José Cocero
CHAPTER 6: Supercritical Fluid Impregnation for The Preparation of Controlled
Delivery Systems 52
Ana Rita C. Duarte, Catarina M. M. Duarte
CHAPTER 7: Ionic Liquids and Carbon Dioxide As Combined Solvents for Reactions
and Separations: Switch the Miscibility 61
E. Kühne, G.J. Witkamp, C.J. Peters
3. NUTRACEUTICAL AND FOOD PROCESSING
CHAPTER 8: Supercritical Antisolvent Fractionation of Plant Extracts 71
O. J. Catchpole, N. E. Durling, J. B. Grey, W. Eltringham, S. J. Tallon
CHAPTER 9: Mathematical Modelling of Supercritical Fluid Extraction 80
H. Sovová
4. SCALE-UP ISSUES
CHAPTER 10: Supercritical Fluid Processing in Food and Pharmaceutical Industries:
Scale-Up Issues 97
Fabrice Leboeuf, Frantz Deschamps
Index 116