+353-1-416-8900REST OF WORLD
+44-20-3973-8888REST OF WORLD
1-917-300-0470EAST COAST U.S
1-800-526-8630U.S. (TOLL FREE)

Cancer Genomics. From Bench to Personalized Medicine

  • Book

  • January 2014
  • Elsevier Science and Technology
  • ID: 2634337

Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment.

Please Note: This is an On Demand product, delivery may take up to 11 working days after payment has been received.

Table of Contents

Introduction 1. Historical Overview

Methodological Approaches and Background 2. Expression Arrays (SNPs, etc.) 3. Tissue micro-arrays (breast, ovarian) 4. Next generation sequencing (DNAseq) 5. RNAseq (breast cancer, sarcomas) 6. Epigenetic Analyses 7. Pharmcogenomics 8. Biomarker discovery through genomics 9. Preclinical models for genomics (cell culture, transgenic animals, xenografts) 10. Bioinformatics and computational methods for data analysis 11. Genomic Resource Projects The Cancer Genome Atlas (TCGA) International Cancer Genome Consortium (ICGC)

Ethics of Genomics Research  12. Ethics of Genomics Research 

The Genomics, Epigenomics and Transcriptomics of Cancer 13. Somatic mutations, Transcription and Epigenetics Overview

Adult Solid Tumors 14. Lung Cancer 15. Breast Cancer 16. Prostate Cancer 17. Colon Cancer 18. Thyroid Cancer

Age Non-specific Tumors and Hematopoietic Malignancies 19. ALL 20. AML 21. NHL 22. Multiple Myeloma 23. Brain Tumors

Pediatric Cancers 24. Neuroblastoma 25. Soft tissue sarcomas 26. Osteosarcoma 27. Wilms Tumors

Germline Mutations and Hereditary Cancer Syndromes 28. Germline Mutations and Hereditary Cancer Syndromes

Future Directions 29. The role of microRNAs and ultraconserved non-coding RNAs in cancer 30. Environmental impact on cancer genomics

Authors

Graham Dellaire Departments of Pathology and Biochemistry and Molecular Biology, Dalhousie University, Nova Scotia, Canada. Jason N Berman Departments of Pediatrics, Microbiology and Immunology, and Pathology, Dalhousie University, Halifax, NS, Canada. Robert J. Arceci Children's Center for Cancer and Blood Disorders, Hematology/Oncology, The Ron Matricaria Institute of Molecular Medicine at Phoenix Children's Hospital, Department of Child Health, University of Arizona, College of Medicine - Phoenix.