Heart disease is the leading cause of death in the United Kingdom and the United States. Advanced cell therapies, tissue engineering and biomaterials technologies now offer the potential to reverse the damage caused by heart disease. The two volumes of Cardiac Regeneration and Repair present a complete picture of our current understanding of cardiac pathologies, and the novel therapies and technologies being developed to address heart disease.
Volume One explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. It highlights new approaches to cell therapy for cardiac regeneration, covering alternative routes of cell delivery, monitoring cell engraftment, and using allogeneic stem cells to restore cardiac function. This volume also explores gene therapy, including ultrasound-targeted or direct gene delivery as well as cell-based gene therapy.
Volume Two surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. This volume also focuses on tissue engineering for cardiac repair, including clinical considerations for cardiac tissue engineering, and explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.
- Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function
- Surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels.
- Explores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration
- Explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels
Volume One explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. It highlights new approaches to cell therapy for cardiac regeneration, covering alternative routes of cell delivery, monitoring cell engraftment, and using allogeneic stem cells to restore cardiac function. This volume also explores gene therapy, including ultrasound-targeted or direct gene delivery as well as cell-based gene therapy.
Volume Two surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. This volume also focuses on tissue engineering for cardiac repair, including clinical considerations for cardiac tissue engineering, and explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.
- Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function
- Surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels.
- Explores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration
- Explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels
Table of Contents
Volume 1 Part 1 The pathogenesis of congestive heart failure: Cardiac matrix remodeling and heart failureCardiac biomechanics and heart dysfunction
Modifying matrix remodeling to prevent heart failure. Part 2 Cell therapy for cardiac regeneration and repair: Optimal cells for cardiac repair and regeneration
Cell delivery routes for cardiac stem cell therapy
Cell therapy to regenerate the ischemic heart
Cell therapy for cardiac repair
bench to bedside and back
Recent advances in cardiac stem cell therapy to restore left ventricular function
Monitoring myocardial functional regeneration following cardiac stem cell application
Feasibility of allogeneic stem cells for heart regeneration
Bone marrow cells and their role in cardiac repair after myocardial infarction. Part 3 Stem cells for cardiac regeneration and repair: Cardiac cell therapy to restore contracting elements
Human embryonic stem cells (hESCs) for heart regeneration
Human pluripotent stem cells (hPSCs) for heart regeneration
Cardiac cell therapy: Current status and future trends. Part 4 Gene therapy for cardiac regeneration and repair: Stem cell and gene therapy for cardiac regeneration
Ultrasound-targeted cardiovascular gene therapy.
Volume 2 Part 1 Biomaterials for cardiac regeneration and repair: Nanotechnology and nanomaterials for cardiac repair
Hydrogels for cardiac repair
Injectable biomaterials for cardiac regeneration and repair
Biomaterials for enhancing endothelial progenitor cell (EPC) therapy for cardiac regeneration
Endothelial progenitor cell (EPC)-seeded intravascular stents. Part 2 Tissue engineering for cardiac regeneration and repair: Biomaterials and cells for cardiac tissue engineering
Decellularized biologic scaffolds for cardiac repair and regeneration
Biomaterial scaffolds for cardiac regeneration and repair derived from native heart matrix
Cell sheet engineering for cardiac repair and regeneration
Maturation of functional cardiac tissue patches
Vascularizing engineered tissues for in vivo and in vitro applications
Clinical considerations for cardiac tissue engineering. Part 3 Vascular remodelling for regeneration and repair: Aortic extra cellular matrix (ECM) remodelling
Cell-biomaterial interactions for blood vessel formation
Stem cells in tissue-engineered blood vessels for cardiac repair
Tissue-engineered cardiovascular grafts and novel applications of tissue engineering by self-assembly (TESAT).
Authors
Li, Ren-KeWeisel, Richard D.
