This new volume of Advances in Pharmacology presents pharmacology of the blood brain barrier, focusing on targeting CNS disorders. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.
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Table of Contents
1. ABC Transporter Regulation by Signaling at the Blood-Brain Barrier: Relevance to PharmacologyDavid S. Miller
2. P-glycoprotein Trafficking as a Therapeutic Target to Optimize CNS Drug Delivery
Thomas P. Davis, Lucy Sanchez-Covarubias and Margaret E. Tome
3. Functional Expression of Drug Transporters in Glial Cells: Potential Role on Drug Delivery to the CNS
Tamima Ashraf, Amy Kao and Reina Bendayan
4. Blood-Brain Barrier Na Transporters in Ischemic Stroke
Martha E. O'Donnell
5. Transcytosis of Macromolecules at the Blood-Brain Barrier
Jane E. Preston, N. Joan Abbott and David J. Begley
6. Drug Delivery to the Ischemic Brain
Brandon J. Thompson and Patrick T. Ronaldson
7. Delivery of Chemotherapeutics Across the Blood-Brain Barrier: Challenges and Advances
Nancy D. Doolittle, Leslie L. Muldoon, Aliana Y. Culp and Edward A. Neuwelt
8. Delivery of Antihuman African Trypanosomiasis Drugs Across the Blood-Brain and Blood-CSF Barriers
Gayathri N. Sekhar, Christopher P. Watson, Mehmet Fidanboylu, Lisa Sanderson and Sarah A. Thomas
9. Delivery of Therapeutic Peptides and Proteins to the CNS
Therese S. Salameh and William A. Banks
10. Engineering and Pharmacology of Blood-Brain Barrier-Permeable Bispecific Antibodies
Danica Stanimirovic, Kristin Kemmerich, Arsalan S. Haqqani and Graham K. Farrington
11. Pharmacological Significance of Prostaglandin E2 and D2 Transport at the Brain Barriers
Masanori Tachikawa, Ken-ichi Hosoya and Tetsuya Terasaki
12. Steroids and the Blood-Brain Barrier: Therapeutic Implications
Ken A. Witt and Karin E. Sandoval
13. Combination Approaches to Attenuate Hemorrhagic Transformation After tPA Thrombolytic Therapy in Patients with Poststroke Hyperglycemia/Diabetes
Xiang Fan, Yinghua Jiang, Zhanyang Yu, Jing Yuan, Xiaochuan Sun, Shuanglin Xiang, Eng H. Lo and Xiaoying Wang
14. Aging, the Metabolic Syndrome, and Ischemic Stroke: Redefining the Approach for Studying the Blood-Brain Barrier in a Complex Neurological Disease
Brandon P. Lucke-Wold, Aric F. Logsdon, Ryan C. Turner, Charles L. Rosen and Jason D. Huber
15. Drug Abuse and the Neurovascular Unit
Richard D. Egleton and Thomas Abbruscato
