In Neuroglia in Alzheimer's Disease, the authors provide a broad overview of glial physiology and pathophysiology, outline glial contribution to neurodegeneration and concentrate on the role of different classes of neuroglial cells in the progression and outcome of Alzheimer's disease. The authors discuss the critical vie of AD and argue for glial cells as new targets for therapy of neurodegenerative disorders. This book is valuable researchers, clinicians, postdocs, and graduate students in the fields of neurobiology, neurology and psychiatry.
Table of Contents
Introduction to Neuroglia Research Neuroglial Cells General Pathology of Neuroglia Neuroglia in Aging Neuroglia in Neurodegeneration Alzheimer's Disease Astroglia in Alzheimer's Disease Microglia in Alzheimer's Disease Myelination and Oligodendroglia in Alzheimer's Disease Neuroglia as a Therapeutic Target
Authors
Alexei Verkhratsky University of Manchester, Manchester, UK.
Professor Verkhratsky, PhD, D.Sc, Member of Academia Europaea (2003), Member of the German National Academy of Sciences Leopoldina (2013), Member of Real Academia Nacional de Farmacia of Spain (2012), member of Polish Academy of Sciences (2017); member of The Dana Alliance for Brain Initiatives (2012), distinguished professor of Chengdu University of Traditional Chinese Medicine and Jinan University graduated from Kiev Medical Institute in 1983, and received PhD (1986) and D.Sc. (1993) in Physiology from Bogomoletz Institute of Physiology also in Kiev. In the period between 1989 and 1995 he was visitor scientist in Heidelberg and Gottingen, and between 1995 and 1999 he was a Research Scientist at Max Delbrück Centre of Molecular Medicine in Berlin. He joined the Division of Neuroscience, School of Biological Sciences in Manchester in September 1999, became a Professor of Neurophysiology in 2002 and served as Head of the said Division from 2002 to 2004. From 2007 to 2010 he was appointed as a visitor professor/Head of Department of Cellular and Molecular Neurophysiology at the Institute of Experimental Medicine, Academy of Sciences of Check Republic. Dr. Verkhratsky also serves as a Research Professor of the Ikerbasque (Basque Research Council) in Bilbao, where, from 2012, he acts as Adjunct Scientific Director of the Achucarro Basque Centre for Neuroscience; from 2011 he has been an Honorary Visitor Professor at Kyushu University, Fukuoka, Japan. Alexei is the editor-in-chief of Cell Calcium, Deputy Editor-in Chief of Cell Death & Disease and member of editorial boards of many journals including Pflugers Archiv, Glia, Acta Physilogica, Purinergic Signalling, etc. Together with Arthur Butt, he published the first ever Textbook on Glial Neurobiology, and in 2013 he, again in co-authorship with Arthur Butt published a handbook Glial Physiology and Pathophysiology, which has rapidly become the reference book in the field. Dr. Verkhratsky is an internationally recognised scholar in the field of cellular neurophysiology. His research is concentrated on the mechanisms of inter- and intracellular signalling in the CNS, being especially focused on two main types of neural cells, on neurones and neuroglia. He authored a pioneering hypothesis of astroglial atrophy as a general mechanism of cognitive brain disorders including neurodegenerative and psychiatric diseases.
Vladimir Parpura Department of Neurobiology, University of Alabama, Birmingham, AL, USA.
Vladimir Parpura, M.D., Ph.D holds both a medical degree, awarded from the University of Zagreb in Croatia in 1989, and a doctorate, received in Neuroscience and Zoology from Iowa State University in 1993. He has held faculty appointments at the Department of Zoology and Genetics, Iowa State University and the Department of Cell Biology and Neuroscience, University of California Riverside. He is presently an Associate Professor in the Department of Neurobiology, University of Alabama Birmingham.
Jose Julio Rodriguez Arellano University of the Basque Country, Bizkaia, Spain.
Dr. Arellano is a Research Professor at the University of Basque Country in Bizkaia, Spain. He founded the Functional Neuroanatomy Laboratory in 2010 at University of Basque Country. His research focuses on Researching on the neuroanatomy and functional connectivity of neural circuits in the context of memory-related plasticity under normal and pathological conditions.
Milos Pekny Sahlgrenska Academy at the University of Gothenburg, Institute of Neuroscience and Physiology, Goteborg, Sweden.
