- New contributors reflecting broader international authorship and even greater expertise
- Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations
- Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date
- Now produced in full color for enhanced clarity
- Covers how molecular genetic data (PCR-based and sequencing information) are collated with the cytogenetic data where pertinent
- Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible
Table of Contents
Contributors vii
Preface to the Fourth Edition ix
1 How it all began: cancer cytogenetics before sequencing 1
Felix Mitelman and Sverre Heim
2 Cytogenetic methods 11
David Gisselsson
3 Cytogenetic nomenclature 19
Sverre Heim and Felix Mitelman
4 Nonrandom chromosome abnormalities in cancer: an overview 26
Sverre Heim and Felix Mitelman
5 From chromosomes to genes: searching for pathogenetic fusions in cancer 42
Ioannis Panagopoulos
6 Acute myeloid leukemia 62
Bertil Johansson and Christine J. Harrison
7 Myelodysplastic syndromes 126
Harold J. Olney and Michelle M. Le Beau
8 Chronic myeloid leukemia 153
Thoas Fioretos
9 Chronic myeloproliferative neoplasms 175
Peter Vandenberghe and Lucienne Michaux
10 Acute lymphoblastic leukemia 198
Christine J. Harrison and Bertil Johansson
11 Mature BÂ] and TÂ]cell neoplasms and Hodgkin lymphoma 252
Reiner Siebert and Sietse M. Aukema
12 Tumors of the upper aerodigestive tract 332
Susanne M. Gollin
13 Tumors of the lung 361
Penny Nymark, Eeva Kettunen and Sakari Knuutila
14 Tumors of the digestive tract 373
Georgia Bardi and Sverre Heim
15 Tumors of the urinary tract 401
Paola Dal Cin
16 Tumors of the breast 426
Manuel R. Teixeira, Nikos Pandis and Sverre Heim
17 Tumors of the female genital organs 447
Francesca Micci and Sverre Heim
18 Tumors of the male genital organs 481
Manuel R. Teixeira and Sverre Heim
19 Tumors of endocrine glands 497
Jörn Bullerdiek and David Gisselsson
20 Tumors of the nervous system 515
Petter Brandal and Sverre Heim
21 Tumors of the eye 538
Karen Sisley
22 Tumors of the skin 555
Fredrik Mertens, Felix Mitelman and Sverre Heim
23 Tumors of bone 566
Fredrik Mertens and Nils Mandahl
24 Soft tissue tumors 583
Nils Mandahl and Fredrik Mertens
Index 615
