This book is a concise, straightforward practical guide to the clinical management of patients having drug resistant tuberculosis infections. It covers every aspect of drug resistant tuberculosis, starting from epidemiology and bacteriology to a description of the latest diagnostic tests and a list of tuberculosis drugs. Readers will find clear guidelines for selection and administration of treatment regimens for the different types of drug resistant tuberculosis infections as well as instructions on follow-up procedures for such cases.
The book also includes a series of clinical cases illustrating some of the most frequent problems encountered by doctors while treating drug resistant tuberculosis in a clinical setting.
Drug Resistant Tuberculosis: Practical guide for clinical management is a useful handbook for general practitioners and medical students interested in learning about multi drug resistant tuberculosis and pulmonary care of patients having advanced infections.
The book also includes a series of clinical cases illustrating some of the most frequent problems encountered by doctors while treating drug resistant tuberculosis in a clinical setting.
Drug Resistant Tuberculosis: Practical guide for clinical management is a useful handbook for general practitioners and medical students interested in learning about multi drug resistant tuberculosis and pulmonary care of patients having advanced infections.
Table of Contents
1. Foreword2. Preface
3. Epidemiology Of Drug Resistant Tuberculosis
- Introduction
- Conflict Of Interest
- Acknowledgements
- References
4. Etiological Agent Of Tuberculosis
- Introduction
- Basic Mechanisms Of Drug Resistance In Mycobacterium Tuberculosis
- Passive Resistance Mechanisms
- Specialized Resistance Mechanisms
- Genetic Mechanisms Of Drug Resistance In Mycobacterium Tuberculosis
- Fitness Cost And Compensatory Mechanisms
5. Conflict Of Interest
6. Acknowledgements
7. References
8. Biological Basis For Drug Resistant Tuberculosis
- Introduction
- Definition And Classification Of Drug Resistance To Antituberculosis Drugs
- Factors Associated To The Development Of Drug Resistance
9. Conflict Of Interest
10. Acknowledgements
11. References
12. Clinical Diagnosis Of Drug Resistant Tuberculosis
13. Introduction
- Clinical Classification Of Drug Resistant Cases
- New Case
- Relapse
- Default
- Failure
- Initial Case Evaluation
14. Conflict Of Interest
15. Acknowledgements
16. References
17. Drug Resistant Tuberculosis: Laboratory Diagnosis
18. Introduction
- Rapid Phenotypic Dst Methods
- Rapid Genotypic Dst
19. Conflict Of Interest
20. Acknowledgements
21. References
22. Antituberculosis Drugs
23. Introduction
24. Group 1 Drugs: First Line Oral Antituberculosis Drugs
- Isoniazid (H)
- Adverse Effects
- Ethambutol (E)
- Adverse Effects
- Pyrazinamide (Z)
- Adverse Effects:
- Rifampin (R)
- Adverse Effects
25. Group 2 Drugs
- Second Line Injectables
- Amikacin (Am)
- Capreomycin (Cm)
- Kanamycin (Km)
26. Group 3 Drugs: Fluoroquinolones
- Gatifloxacin (Gfx)
- Adverse Effects
- Levofloxacin (Lfx)
- Adverse Effects
- Moxifloxacin (Mfx)
- Adverse Effects
27. Group 4 Drugs: Second Line Oral Antituberculosis Drugs
- Cycloserine (Cs)
- Adverse Effects
- Ethionamide (Eth)
- Adverse Effects
- Para-Aminosalicylate (Pas)
- Adverse Effects
28. Group 5 Drugs: (With The Exception Of Linezolid With Virtually No Evidence
Of Their Efficacy)
- Amoxicillin/Clavulanate (Amx/Clv)
- Adverse Effects:
- Clofazimine (Cfz)
- Adverse Effects:
- Imipenem/Cilastatin (Imp/Cln)
- Adverse Effects:
- Meropenem (Mer)
- Adverse Effects:
- Linezolid (Lzd)
- Adverse Effects:
29. New Drugs Available For Clinical Use
- Bedaquiline (Bq)
- Adverse Effects
- Delamanid
- Adverse Effects
30. Conclusions On New Drugs For Mdr-Tb
31. Conflict Of Interest
32. Acknowledgements
33. References
34. Treatment Of Drug Resistant Tuberculosis
35. Introduction
36. Treatment Of Drug Resistant Tuberculosis
37. Treatment For Mono-Resistance
- Isolated Resistance To Isoniazid (H)
- Isolated Resistance To Rifampin (R)
- Isolated Resistance To Ethambutol (E), Pyrazinamide (Z) Or Streptomycin (S)
38. Treatment For Polyresistant Cases
- Resistance To Isoniazid And Pyrazinamide
- Resistance To Isoniazid And Ethambutol
- Resistance To Rifampin And Ethambutol (± Streptomycin)
- Resistance To Rifampin And Pyrazinamide (± Streptomycin)
- Resistance To Isoniazid + Ethambutol + Pyrazinamide (± Streptomycin)
39. Building A Regimen For Mdr-Tb
- Practical Aspects Of Multidrug Resistant Tuberculosis Treatment
- Surgery For Patients With Drug Resistant Tb
40. Short Course Treatment For Mdr-Tb: The “Bangladesh Regimen”
- Individualized Or Standardized Treatment ?
41. Who Guidelines For The Programmatic Management Of Drug-Resistant
42. Tuberculosis – 2011 Update
43. Extensively Drug Resistant Tuberculosis
44. Conflict Of Interest
45. Acknowledgements
46. References
47. Adverse Effects And Toxicity Of Antituberculosis Drugs
48. Introduction
49. Adverse Effects And Toxicity
- Hypersensitivity And Cutaneous Reactions
- Pruritus And Maculopapular Rash
- Lichenoid Reactions
50. Peripheral Neuropathy
51. Central Nervous System Side Effects
- Eighth Cranial Nerve Toxicity
52. Ophthalmic Toxicity
53. Gastrointestinal Toxicity
- Hepatotoxicity
54. Adverse Hematologic Effects
55. Hypothyroidism
56. Nephrotoxicity
57. Musculoskeletal Adverse Effects
58. Conflict Of Interest
59. Acknowledgements
60. References
61. Follow Up Of Drug Resistant Cases During Treatment
62. Follow-Up Of Hospitalized Patients
63. Outpatient Monitoring
64. When Can Isolation And The Use Of Facemasks Can Be Discontinued In A
Patient With Drug Resistant Tuberculosis?
65. Conflict Of Interest
66. Acknowledgements
67. References
68. Drug Resistant Tuberculosis In Special Situations
69. Hiv Co-Infection
70. Timing For Initiation Of Treatment With Arv Drugs In Patients Co-Infected With Tb And Hiv
71. Mdr-Tb And Pregnancy
72. Drug Resistant Tuberculosis In Children
73. Treatment Of Drug Resistant Tuberculosis In Children
74. Treatment Of Pediatric Contacts Of Mdr-Tb Cases
75. Conflict Of Interest
76. Acknowledgements
77. References
78. Hypothetical Illustrative Cases
Case 1
- Commentary
Case 2
- Commentary
Case 3
- Commentary
Case 4
- Commentary
Case 5
- Commentary
79. Conflict Of Interest
80. Acknowledgements
81. References
82. Subject Index
