Transplantation of the Liver. Edition No. 3

Table of Contents

I: General Considerations

1. History of Liver Transplantation

2. Surgical Anatomy of the Liver

3. Molecular and Cellular Basics of Liver Failure

4. Influence of Transplantation on Liver Surgery

5. Organ Allocation: The US Model

6. Organ Allocation: The European Models

7. Donation After Cardiac or Brain Death: Regulatory and Ethical Principles

II: Patient Evaluation: Adult

8. Current Indications, Contraindications, Delisting Criteria, and Timing for Transplantation

9. Transplantation for Hepatitis A and B

10. Natural History of Hepatitis C

11. Transplantation for Hepatitis C

12. Transplantation for Fulminant Hepatic Failure

13. Transplantation for Primary Biliary Cirrhosis

14. Transplantation for Sclerosing Cholangitis

15. Transplantation for Autoimmune Hepatitis

16. Transplantation for Primary Hepatic Malignancy

17. Transplantation for Cholangiocarcinoma

18. Transplantation for Metastases

19. Transplantation for Hematological Disorders

20. Transplantation for Budd-Chiari Syndrome

21. Transplantation for Alcoholic Liver Disease

22. Transplantation for Nonalcoholic Steatohepatitis

23. Unusual Indications for Transplantation

III: Patient Evaluation: Pediatric

24. General Criteria for Transplantation in Children

25. Transplantation for Cholestatic Liver Disease in Children

26. Transplantation for Biliary Atresia in Children

27. Transplantation for Metabolic Disease in Children

28. Transplantation for Hepatic Malignancy in Children

IV: Special Considerations in Patient Evaluation

29. Ethical Decisions in Transplantation

30. Psychiatric Assessment of Liver Transplant Candidates

31. Pretransplantation Evaluation: Cardiac

32. Pretransplantation Evaluation: Renal

33. Pretransplantation Evaluation: Infectious Disease

34. Role of the Clinical Nurse Coordinator

35. Radiological Evaluation in Transplantation

36. Monitoring and Care

37. Nutritional Aspects of Transplantation in Adults

38. Management of Portal Hypertensive Hemorrhage

39. Portopulmonary Hypertension and Hepatopulmonary Syndrome

V: Operation

40. Donor Selection and Management

41. Extended Criteria Donors

42. Donating After Cardiac Death

43. The Donor Operation

44. Principles of Liver Preservation

45. Recipient Hepatectomy and Grafting

46. Anesthesia for Liver Transplantation

VI: Split and Living Donor Transplantation

47. Imaging Techniques for Partial Grafting

48. Living Donor Transplantation in Children

49. Living Donor Transplantation: Evaluation and Selection in Adults

50. Adult Living Donor Right Hepatectomy and Recipient Operation

51. Adult Living Donor Left Hepatectomy and Recipient Operation

52. Split Liver Transplantation for Pediatric and Adult Recipients

53. Split Liver Transplantation for Two Adult Recipients

54. Biliary and Vascular Reconstruction in Living Donor Transplantation

55. Small-for-Size Syndrome

56. Minimally Invasive Living Donor Hepatectomy

57. Dual Grafts for Transplantation

58. Outcomes of Living Donor Transplantation: The Western Perspective

59. Outcomes of Living Donor Transplantation: The Eastern Perspective

60. Ethics of Living Donor Transplantation

VII: Unusual Operative Problems

61. Arterial Reconstruction Pitfalls

62. Portal Vein Thrombosis and Other Venous Anomalies

63. Combined Liver-Kidney Transplantation

64. Retransplantation

65. Clinical Management of Necrotic Liver Before and After Transplantation

66. Intestinal and Multivisceral Transplantation

67. Transplantation: Situs Inversus and Polysplenia Syndrome

68. Auxiliary Transplantation

VIII: Postoperative Care

69. Postoperative Intensive Care Management in Adults

70. Postoperative Intensive Care Management in Children

71. Postoperative Management Beyond the Intensive Care Unit: Adults

72. Postoperative Care of Pediatric Transplant Recipients

73. Transition of Pediatric Patients to Adulthood

74. Renal Failure in Adults

75. Graft Failure

76. Technical Problems: Biliary

77. Arterial Complications after Transplantation

78. Infections After Transplantation

79. Recurrent Hepatitis C After Transplantation

80. Late Complications and Recurrence of Disease After Transplantation

81. Neuropsychiatric Complications

82. Neurological Complications

83. Role of the Posttransplantation Clinical Nurse Coordinator

IX: Transplant Pathology

84. Histopathology of Liver Transplantation

85. Pathology of NonNeoplastic Disease After Transplantation

86. Transplant-Related Malignancies

X: Immunology of Liver Transplantation

87. Rejection After Transplantation

88. Leukocyte Chimerism- Meaning and Consequences

89. ABO, Tissue Typing, and Crossmatching Incompatibility

90. Graft-Versus-Host Disease

XI: Immunosuppression

91. Induction and Maintenance of Immunosuppression

92. Special Considerations for Immunosuppression In Children

93. Treatment of Acute and Chronic Rejection

94. Novel Immunosuppression of Patients with Hepatic Malignancies

95. Novel Immunosuppressive Drugs

96. Immunosuppressive Biologic Agents

97. Long-term Toxicity of Immunosuppressive Therapy

XII: Survival and Results

98. Outcome Predictors in Transplantation

99. U.S. Trends in Transplantation

100. Long-term Functional Recovery and Quality of Life

101. Survival and Quality of Life in Children

XIII: Future Developments in Liver Transplantation

102. Genetic and Genomic Potentials in Liver Transplantation

103. Liver and Hepatocyte Xenotransplantation

104. Stem Cell and Liver Regeneration

105. Ischemia-Reperfusion Injury in Liver Transplantation

106. Extracorporeal Perfusion for Resuscitation of Marginal Grafts

107. Current Clinical Status of Extracorporeal Devices

Authors

Ronald W. Busuttil William P. Longmire, Jr. Chair in Surgery, Distinguished Professor and Executive Chairman, UCLA Department of Surgery , Chief, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, California. Dr. Ronald W. Busuttil is Distinguished Professor and Executive Chairman of the UCLA Department of Surgery and holds the William P. Longmire, Jr. Chair in Surgery. He is the founding Chief of the Division of Liver and Pancreas Transplantation and Director of the Pfleger Liver Institute. In 1984, he founded the Liver Transplant Program at UCLA and has been the Director and Chief Surgeon for 28 years. Dr. Busuttil has authored more than 600 peer reviewed scientific manuscripts, 55 book chapters, and 400 abstracts. He is a Past President of the International Liver Transplantation Society, a Past President of the American Society of Transplant Surgeons, Past First Vice President of the American Surgical Association, a past member of the council of The Transplantation Society, and has served on the Board of Directors of United Network for Organ Sharing. Goran B. Klintmalm Chief and Chairman, Annette C. and Harold C. Simmons Transplant Institute, W.W. Caruth Chair in Organ Transplant Immunology, Professor of Surgery, Texas A&M College of Medicine, Vice Chair, Department of Surgery, Division Chief, Transplant Surgery, Dallas, Texas. Dr. Goran Klintmalm is chairman and chief of the Annette C. and Harold C. Simmons Transplant Institute at Baylor University Medical Center in Dallas, Texas, and past President of the American Society of Transplant Surgeons (ASTS). Dr. Klintmalm began the first multi-organ transplant program at Baylor in 1984. The program has now performed over 4,300 liver transplants and over 4,600 kidney transplants to date. In 1999, he performed the first split liver transplant in North Texas and the first adult living donor transplant in Texas in 2001. Dr. Klintmalm is the author of more than 450 peer-reviewed and over 80 non-peer-reviewed publications, editor of 45 textbooks chapters and 250 published abstracts. He is the Editor of 5 textbooks and has served as editor/associate editor/reviewer for multiple journals. established and has maintained the Baylor Biorepository and prospective Clinical Research Database in liver transplantation since 1985.