The neuromarkers identified in this book have a diagnostic sensitivity and specificity higher than 80%. They are reliable, reproducible, inexpensive to measure, noninvasive, and have been confirmed by at least two independent studies. The book focuses primarily on the analysis of EEG and ERPs. It elucidates the neuronal mechanisms that generate EEG spontaneous rhythms and explores the functional meaning of ERP components in cognitive tasks. The functional neuromarkers for ADHD, schizophrenia, and obsessive-compulsive disorder are reviewed in detail. The book highlights how to use these functional neuromarkers for diagnosis, personalized neurotherapy, and monitoring treatment results.
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Table of Contents
Introduction
Part 1 Methods of assessing neuromarkers Chapter 1.1 Theory of measurement Chapter 1.2 Psychometrics and neuropsychological assessment Chapter 1.3 Functional MRI Chapter 1.4 Positron emission tomography Chapter 1.5 Spontaneous electroencephalogram Chapter 1.6 Event-related potentials
Part 2 Neuromarkers of cortical self-regulation Chapter 2.1 Infraslow electrical oscillations Chapter 2.2 Alpha rhythms Chapter 2.3 Beta and gamma rhythms Chapter 2.4 Frontal midline theta rhythm
Part 3 Information flow within the brain Chapter 3.1 Sensory systems and attention modulation Chapter 3.2 Executive system and cognitive control Chapter 3.3 Affective system, emotions and stress Chapter 3.4 Memory systems
Part 4 Methods of neuro-modulation Chapter 4.1 Pharmacological approach Chapter 4.2 Neurofeedback Chapter 4.3 Electroconvulsive therapy Chapter 4.4 Transcranial Direct Current Stimulation Chapter 4.5 Transcranial magnetic stimulation Chapter 4.6 Deep Brain Stimulation
Part 5 Neuromarkers in psychiatry Chapter 5.1 Attention deficit hyperactivity disorder Chapter 5.2 Schizophrenia Chapter 5.3 Obsessive-compulsive disorder
Part 6 Assessing functional neuromarkers Chapter 6.1 Working hypothesis Chapter 6.2 Technical implementation Chapter 6.3 Testing working hypothesis: spontaneous EEG Chapter 6.4 Testing working hypothesis: Event-Related Proposals Chapter 6.5 Monitoring treatment effects
Part 7 The State of the Art: Overview
Chapter 7.1 Objective Measures of Human Brain Functioning
Chapter 7.2 Rhythms of the Healthy Brain
Chapter 7.3 Information Flow in the Health Brain
Chapter 7.4 Current Treatment Options in Psychiatry
Chapter 7.5 Functional Neuromarkers in Diseased Brain
Chapter 7.6 Implementation in Clinical Practice