Cancer Stem Cells. Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance

Table of Contents

Foreword by Jane Visvader and Stanton Gerson Section I. CSC Overview and Methodology

1. Introduction: Cancer Stem Cells Siddhartha S. Mitra, Joy He, Rogelio Esparza, Gregor Hutter, Samuel H. Cheshier and Irving Weissman

2. Overview: Cancer Stem Cell Self-Renewal Maider Zabala, Neethan A. Lobo, Dalong Qian, Linda J. van Weele, Diane Heiser and Michael F. Clarke

3. Enrichment and Interrogation of Cancer Stem Cells Awad Jarrar, Anastasia Chumakova, Masahiro Hitomi, Justin Lathia

Section II. CSCs in Representative Organ systems

4. Critical Updates to the Leukemia Stem Cell Model Yogen Saunthararajah

5. Breast cancer stem cells and the move toward high resolution stem cell systems Benjamin T. Spike

6. Lung Cancer Stem Cells:  Drivers of Genetically and Histologically Complex Disease Christine M. Fillmore and Carla F. Kim

7. Colorectal cancer stem cells Sumaiyah Rehman, Jennifer Haynes, Evelyne Lima-Fernandes, Akshita Puri, Andrew Haller, Cherry Leung, Lauren Agro, Yadong Wang, and Catherine A. O'Brien

8. Targeting Bladder Cancer Stem Cells: One-Step Closer To The Clinic? Antonina Kurtova and Keith Syson Chan

9. Cancer Stem Cells as New therapeutic Targets for Ovarian Cancer Yinu Wang, Fang Fang, Salvatore Condello, Daniela Matei and Kenneth P. Nephew

Section III. CSC Features and Mechanisms

10. Understanding Cancer Cells of Origin in Cutaneous Tumors Hyeongsun Moon, Leanne R. Donahue, Andrew C. White

11. Asymmetric Division of Cancer Stem Cells Claudia Petritsch and Xiling Shen

12. Metastasis and Metastatic Cells:  A Historical Perspective and Current Analysis   Kiera Rycaj and Dean G. Tang

13. Metastasis and Evasion from the Host Immune Responses Avijeet Chopra, Xia Liu, Huiping Liu

14. Cancer Stem Cells and Tumor Associated Macrophages Wenchao Zhou and Shideng Bao

15. The Mechanisms of Therapy Resistance in Cancer Stem Cells Chi-Hsuan Chang and Jeffrey M. Rosen

16. Adipose tissue-derived stem cells in regenerative medicine and impact on cancer Praveena S. Thiagarajan, Justin D. Lathia, and Ofer Reizes

Section IV. Clinical Applications

17. From Research to the Clinic: Targeting Stem Cell Pathways in Cancer Austin Gurney and Timothy Hoey

18. Targeted Therapies for Glioma Stem Cells Swetha J. Sundar, James Wright, Jason K. Hseih & Andrew E. Sloan

19. Circulating tumor cells, cancer stem cells, and emerging microfluidic detection technologies with clinical applications Molly Kozminsky and Sunitha Nagrath

Authors

Huiping Liu Assistant Professor, Department of Pathology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA. Dr. Huiping Liu is an expert in breast cancer stem cells and metastasis. She is co-director of the Cancer Stem Cell Conference in 2014 and 2016 with Justin Lathia. Dr. Liu's research recently has been focused on thoroughly understanding the role of microRNAs in breast cancer stem cells, metastasis, and therapy resistance. The goals of the Liu laboratory are to control metastasis and eliminate the mortality associated with breast cancer and other types of cancer. She is known as an active collaborator - bridging research in basic science, engineering, and clinical medicine by engaging physicians and researchers across many institutions. Thus, she is very well known in the field and highly regarded as both a researcher and conference organizer. Justin Durla Lathia Assistant Professor, Department of Cellular and Molecular Medicine (NC10), Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA. Dr. Lathia is an expert in brain tumor stem cells. He is co-director of the Cancer Stem Cell Conference in 2014 and 2016 with Huiping Liu. Dr. Lathia's research has two main areas of focus: using in vivo imaging models to interrogate the tumor microenvironment and examining communication mechanisms used by cancer stem cells to promote their maintenance. His lab is focused on understanding cancer stem cells in real time, so they can be better eliminated by therapy and, thus, prevent tumors from forming, metastasizing, and becoming resistant to therapy.