- Provides essential practical management for all those working in the field of hemostasis and thrombosis
- Includes new chapters on direct oral anticoagulants, acquired inhibitors of coagulation, and expanded discussion of thrombotic microangiopathies
- Covers in a clear and succinct format, the diagnosis, treatment and prevention of thrombotic and haemostatic disorders
- Follows templated chapter formats for rapid referral, including key points and summary boxes, and further reading
- Highlights controversial issues and provides advice for everyday questions encountered in the clinic
Table of Contents
List of Contributors ix
1 Basic Principles Underlying Coagulation 1
Dougald M. Monroe
2 Laboratory Tests of Hemostasis 12
Steve Kitchen and Michael Makris
3 Molecular Diagnostic Approaches to Hemostasis 27
Paula James and David Lillicrap
4 Tests of Platelet Function 42
Marie Lordkipanidzé, Gillian C. Lowe and Paul Harrison
5 Evaluation of the Bleeding Patient 63
Alice Ma and Marshall Mazepa
6 Hemophilia A and B 79
Rhona M. Maclean and Michael Makris
7 Von Willebrand disease 94
Giancarlo Castaman, Alberto Tosetto and Francesco Rodeghiero
8 The Rarer Inherited Coagulation Disorders 113
Paula H.B. BoltonÂ-Maggs, Jonathan Wilde and Gillian N. Pike
9 Acquired Inhibitors of Coagulation 124
Riitta Lassila and Elina Armstrong
10 Quantitative Platelet Disorders 134
Riten Kumar and Walter H.A. Kahr
11 Qualitative Platelet Disorders 160
Eti A. Femia Gian Marco Podda and Marco Cattaneo
12 Disseminated Intravascular Coagulation 172
Raj S. Kasthuri and Nigel S. Key
13 Thrombotic Microangiopathies 183
Marie Scully and David Kavanagh
14 Venous Thromboembolism 195
Sarah Takach Lapner, Lori-Ann Linkins and Clive Kearon
15 Myeloproliferative Neoplasms: Thrombosis and Hemorrhage 210
Brandi Reeves and Stephan Moll
16 Arterial Thrombosis 229
R. Campbell Tait and Catherine N. Bagot
17 Anticoagulation: Heparins and Vitamin K Antagonists 240
Gualtiero Palareti and Benilde Cosmi
18 The Direct Oral Anticoagulants 253
David A. Garcia, Mark A. Crowther and Walter Ageno
19 Antiphospholipid Syndrome 269
Henry G. Watson and Mark Crowther
20 Cardiovascular Medicine 282
Sreekanth Vemulapalli and Richard C. Becker
21 Cardiothoracic Surgery 299
Denise O’Shaughnessy and Ravi Gill
22 Neurology 314
Michael Wang, Natalie Aucutt-Walter, Valerie L. Jewells and David Y. Huang
23 Hepatology 329
Lara N. Roberts, Raj K. Patel and Roopen Arya
24 Nephrology 340
Vimal K. Derebail and Thomas L. Ortel
25 Oncology 355
Anna Falanga and Marina Marchetti
26 Obstetrics, Contraception, and Estrogen Replacement 379
Amy Webster and Sue Pavord
27 Pediatrics 393
Mary E. Bauman, Aisha Bruce and M. Patricia Massicotte
28 Intensive and Critical Care 414
Beverley J. Hunt
29 Transfusion 433
Adrian Copplestone
Appendix 1 Reference Ranges 444
Steve Kitchen and Michael Makris
Index 452
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