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Highlights
Protagonist Therapeutics Inc (Protagonist) is a biopharmaceutical company. It specialises in developing peptide-based new chemical entities, with its leading candidates, Rusfertide and Oral Hepcidin, in advanced clinical stages. Rusfertide (PTG-300) is an injectable hepcidin mimetic for polycythemia vera, enhancing iron regulation and managing hematocrit levels. Icotrokinra, an Oral IL-23R peptide antagonist, targets psoriatic arthritis, ulcerative colitis and Crohn’s disease.PN-881 is an oral IL-17 antagonist that targets psoriasis, psoriatic arthritis, hidradenitis suppurativa and spondyloarthritis. The company is developing peptide antagonists for conditions such as hidradenitis suppurativa, spondyloarthritis, plaque psoriasis and psoriatic arthritis. Protagonist is headquartered in Newark, California, the US.Protagonist Therapeutics Inc Key Recent Developments
- Feb 25, 2026: Protagonist Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Corporate Update
- Feb 24, 2026: Protagonist Therapeutics to Participate in Multiple Investment Bank Conferences in March 2026
- Dec 06, 2025: Protagonist and Takeda Present 52-Week VERIFY Data Showing Rusfertide Durably Controls Hematocrit in Polycythemia Vera
- Oct 27, 2025: Protagonist Presents New Icotrokinra Data in Ulcerative Colitis and Plaque Psoriasis
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Table of Contents
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- Rigel Pharmaceuticals Inc
- Phathom Pharmaceuticals Inc
- UCB SA
- Arena Pharmaceuticals Inc
- Ardelyx Inc

