Voet′s PRINCIPLES OF BIOCHEMISTRY
Voet′s Principles of Biochemistry, Global Edition addresses the enormous advances in biochemistry, particularly in the areas of structural biology and bioinformatics. It provides a solid biochemical foundation that is rooted in chemistry to prepare students for the scientific challenges of the future. New information related to advances in biochemistry and experimental approaches for studying complex systems are introduced. Notes on a variety of human diseases and pharmacological effectors have been expanded to reflect recent research findings. While continuing in its tradition of presenting complete and balanced coverage, this Global Edition includes new pedagogy and enhanced visuals that provide a clear pathway for student learning.
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Table of Contents
PART I INTRODUCTION1 Life, Cell and Thermodynamics 1
2 Physical and Chemical Properties of Water 23
PART II BIOMOLECULES
3 Overview of DNA Structure, Function, and Engineering 42
4 Amino Acids 80
5 Polypeptide Analysis, Sequencing and Evolution 97
6 Proteins: Structure and Folding 131
7 Physiological Activities of Proteins 180
8 Saccharide Chemistry 221
9 Lipids, Bilayer and Membranes 245
10 Passive and Active Transport 293
PART III ENZYMES
11 Mechanisms of Enzyme Action 322
12 Properties of Enzymes 361
13 Hormones and Signal Transduction 402
PART IV METABOLISM
14 Bioenergetics 442
15 Glycolysis and the Pentose Phosphate Pathway 478
16 Additional Pathways in Carbohydrate Metabolism 523
17 The Citric Acid Cycle 558
18 Mitochondrial ATP Synthesis 588
20 Synthesis and Degradation of lipids 664
21 Synthesis and Degradation of Amino Acids 718
22 Regulation of Fuel Metabolism 773
PART V GENE EXPRESSION AND REPLICATION
23 Nucleotide Synthesis and Degradation 802
24 DNA structure and Interactions with Proteins 831
25 DNA Synthesis and Repair 879
26 RNA Metabolism 938
27 The Genetic Code and Translation 982
28 Gene Expression in Prokaryotes and Eukaryotes 1033
Glossary G-1
Index I-1
