A guide to state-of-the-art cancer immunotherapy in translational cancer research
A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues.
Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and:
- Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care
- Filled with the concepts, examples, and approaches for developing individualized therapy
- Explores the breath of treatments that reflect the complexity of the immune system itself
- Includes contributions from a panel international experts in the field of immunotherapy
Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.
Table of Contents
Editors vi
Contributors vii
Introduction ix
1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer 1
Saranya Chumsri and Keith L. Knutson
2 Monoclonal Antibody Therapy 12
Elizabeth A. Mittendorf and Sabitha Prabhakaran
3 Somatic Mutations and Immunotherapy 24
Eric Tran
4 Checkpoint Blockade 37
Tracy A. Proverbs‐Singh Jedd Wolchok and Alexandra Snyder
5 Myeloid Leukemia Vaccines 54
Paul M. Armistead and Jonathan S. Serody
6 Cancer Vaccines for Solid Tumors 72
Timothy J. Vreeland Garth S. Herbert and George E. Peoples
7 Immunotherapy with Non–Genetically Modified T Cells 91
Cassian Yee
8 Immunotherapy with Genetically Modified T Cells 101
Liora Schultz and Crystal Mackall
9 Immunomodulation with Adjuvants and Cytokines 115
Dae won Kim and Adi Diab
10 Immune Cell Migration in Cancer and Immunotherapy 132
Timothy Murray and Daniel E. Speiser
11 Repurposing of Drugs for Immunotherapy 143
Jyothishmathi Swaminathan and Vidya Gopalakrishnan
12 Immunomodulation with Radiation 161
Jonathan E. Schoenhals Taylor R. Cushman, Alexandra P. Cadena Sandra Demaria and James W. Welsh
13 Good Manufacturing Practices Facilities for Cellular Therapy 177
Andrew D. Fesnak and Bruce L. Levine
14 T Cell Receptor Mimic Antibodies 186
Gheath Alatrash and Jeffrey J. Molldrem
15 Stem Cell Transplantation for Treatment of Malignancy 201
Lohith S. Bachegowda and Richard E. Champlin
16 Natural Killer Cell–Based Immunotherapy 215
Jennifer A. Foltz Jeffrey S. Miller and Dean A. Lee
17 Immunologic Monitoring in Immuno‐Oncology 228
William R. Gwin and Mary L. Disis
18 Cell‐Based Therapies for Canine Cancer 252
Nicola J. Mason and M. Kazim Panjwani
19 Interaction between Targeted Therapy and Immunotherapy 268
Peter A. Prieto Miles C. Andrews, Alexandria P. Cogdill, and Jennifer A. Wargo
Index 286
