Filling a huge gap and bridging the knowledge between the various subdisciplines, this is a well–structured overview for both beginners and more advanced researchers in academia and industry. The two experienced and excellent scientist authors include many applications, so that readers can see how the theories are applied in real life.
A must–have for many inorganic and organic chemists, material and life scientists, as well as pharmaceutical developers.
A must–have for many inorganic and organic chemists, material and life scientists, as well as pharmaceutical developers.
Table of Contents
INTRODUCTIONdefinitions and history
advantages
green chemistry
solvent–free chemistry
solvent–limited chemistry
energy–limited chemistry
biochemical context
METHODS AND INSTRUMENTS
Manual methods
Mechanically activated ageing
Grinder mills
Planetary mills
Screw extrusion
Equipment choice, design and manufacture
CHARACTERISATION
Diffraction techniques
Spectroscopic techniques
Thermal analysis
MECHANISMS
Stepwise mechanisms
Formation of intermediatesTopological considerations
Amorphous phase formation
Thermodynamic rationalisations/phase diagram interpretations
ADVANCED METHODS AND CATALYSIS
Catalysis
Liquid–assisted grinding (LAG)
Ion– and liquid–assisted grinding (ILAG)
Grinding–annealing techniques
ORGANIC SYNTHESIS
Different types of organic reactions
Approaches – stepwise and single–step (one–pot) synthesis
METAL–ORGANIC SYNTHESIS AND METAL–ORGANIC FRAMEWORKS (MOFS)
Design
Small molecules
Linear and sheet polymers
Porous and non–porous MOFs
Zeolitic imidazolate frameworks
Porosity and functional behaviour
Mechanisms and mechanochemical interconversion of porous/non–porous topologies
SUPRAMOLECULAR SYNTHESIS
Design
Molecular recognition: cocrystals, inclusion complexes
One–pot multiple recognition and molecular assembly process
Solid–state self–assembly: small molecules and molecular cages
Computational/theoretical approaches
INORGANIC SYNTHESIS
Design
Mixed salts and oxides
Composite materials
Alloying
Nano–sized materials
COMPARISON TO RELATED TECHNIQUES
Sonochemistry
Microwave synthesis
PHARMACEUTICAL AND INDUSTRIAL APPLICATIONS
Solid forms
Cocrystals
Salts
Screening
Scaling–up methods
RELATED SOLID–STATE METHODOLOGIES
Topochemistry
Photochemical solid–state reactions
Thermochemical solid–state reactions
Gas–solid reactions
Microscopic methods: nanoscratching and nanoindentation
SELECTED PRACTICAL PREPARATIVE EXPERIMENTS
Supramolecular
Metal–organic
Organic
Inorganic
