The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases.
An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.
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Table of Contents
Introduction 1. The history of the mosaic of autoimmunity 2. The novel aspects on the mosaic of autoimmunityCellular and molecular mechanisms 3. B cells 4. B-reg 5. T cells 6. Th17 cells 7. NK cells 8. Dendritic cells 9. Complement 10. Autoantibodies 11. Anti-DSF70 12. Genetic 13. Epigenetic 14. Post-translational modifications 15. Cytokines and chemokines 16. Autophagy 17. Diagnostic: laboratory 18. Diagnostic: imaging
The classical factors associated with autoimmunity 19. Hormones 20. Microbiota 21. Infections: Viruses and bacteria
The novel environmental factors associated with autoimmunity 22. Geo-epidemiology 23. Seasonality 24. UV 25. Vitamin D 26. Vitamin D pregnancy and autoimmunity 27. Smell 28. Breast feeding 29. Vaccines 30. Silicone 31. Diet: spicy food and fatty acids 32. Diet: gluten 33. Psychological stress 34. Coffee 35. Obesity 36. Physical activity 37. Smoke 38. Cannabis 39. Bisphenol 40. Prolactin
Peculiar aspects 41. Cancer 42. Paraneoplastic syndromes
Classical autoimmune diseases 43. SLE 44. APS 45. CAPS 46. RA and inflammatory arthritides 47. PsA and Spondyloarthropathies 48. MS, MG and other neurological disorders 49. Systemic slcerosis 50. Sjogren 51. ASIA syndrome 52. Reproductive failure 53. Accelerated atherosclerosis 54. New autoimmune diseases
Treatment of autoimmune diseases 55. Neuroimmunology 56. Vasculitis 57. Personalized Medicine 58. Biologics and Biosimilars 59. Small molecules 60. Helminthes 61. Novel therapies and IVIg 62. Autoimmune and allergic disease 63. EBV Molecular Diagnosis 64. Statin and myositis 65. Autoimmunity and primary immunodeficiency
