Drug Overview
Nucala (mepolizumab; GlaxoSmithKline) is a humanized monoclonal immunoglobulin G1 antibody that binds to interleukin (IL)-5, which plays a significant role in the activation, proliferation, and differentiation of eosinophils. The drug inhibits the binding of IL-5 to the receptors on the surface of eosinophils, thereby reducing blood, tissue, and sputum eosinophil levels. Nucala gained US and EU approvals for use in asthma in November 2015 and December 2015, respectively. In Japan, the drug was approved in March 2016.
Nucala (mepolizumab; GlaxoSmithKline) is a humanized monoclonal immunoglobulin G1 antibody that binds to interleukin (IL)-5, which plays a significant role in the activation, proliferation, and differentiation of eosinophils. The drug inhibits the binding of IL-5 to the receptors on the surface of eosinophils, thereby reducing blood, tissue, and sputum eosinophil levels. Nucala gained US and EU approvals for use in asthma in November 2015 and December 2015, respectively. In Japan, the drug was approved in March 2016.
Table of Contents
OVERVIEWDrug Overview
Product Profiles
Nucala: Chronic obstructive pulmonary disease (COPD)
Nucala: Asthma
LIST OF FIGURES
Figure 1: The authors drug assessment summary of Nucala for COPD
Figure 2: The authors drug assessment summary of Nucala for COPD
Figure 3: Nucala for asthma – SWOT analysis
Figure 4: The authors drug assessment summary of Nucala in asthma
Figure 5: The authors drug assessment summary of Nucala in asthma
Figure 6: Nucala sales for asthma across the US, Japan, and five major EU markets, by country, 2017–26
LIST OF TABLES
Table 1: Nucala drug profile
Table 2: Nucala Phase III data in COPD
Table 3: Nucala drug profile
Table 4: Nucala pivotal trial data in asthma
Table 5: Nucala late-phase trial data in asthma
Table 6: Nucala Phase III trials in asthma
Table 7: Nucala sales for asthma across the US, Japan, and five major EU markets, by country ($m), 2017–26
