Personalized Psychiatry

Table of Contents

Preface Bernhard Theodor Baune 1. What is personalized psychiatry and why is it necessary? Bernhard Theodor Baune 2. The modeling of trajectories in psychotic illness Scott R. Clark, Klaus Oliver Schubert, and Bernhard T. Baune 3. Mood trajectories as a basis for personalized psychiatry in young people Klaus Oliver Schubert, Scott R. Clark, Linh K. Van, Jane L. Collinson, and Bernhard T. Baune 4. Transdiagnostic early intervention, prevention, and prediction in psychiatry Cristina Mei, Barnaby Nelson, Jessica Hartmann, Rachael Spooner, and Patrick D. McGorry 5. Early intervention, prevention, and prediction in mood disorders: Tracking multidimensional outcomes in young people presenting for mental health care Elizabeth M. Scott, Joanne S. Carpenter, Frank Iorfino, Shane P.M. Cross, Daniel F. Hermens, Django White, Rico S.Z. Lee, Sharon L. Naismith, Adam J. Guastella, Nicholas Glozier, F. Markus Leweke, Dagmar Koethe, Jim Lagopoulos, Jan Scott, Blake A. Hamilton, Jacob J. Crouse, Ashleigh M. Tickell, Alissa Nichles, Natalya Zmicerevska, Lillian J. Gehue, Manreena Kaur, Kate M. Chitty, and Ian B. Hickie 6. Consumer participation in personalized psychiatry Harris A. Eyre, Elisabeth R.B. Becker, Marissa S. Blumenthal, Ajeet B. Singh, Cyrus Raji, Arshya Vahabzadeh, Zoe Wainer, and Chad Bousman 7. Experimental validation of psychopathology in personalized psychiatry Alfons O. Hamm 8. Deep brain stimulation for major depression: A prototype of a personalized treatment in psychiatry Thomas E. Schlaepfer and Bettina H. Bewernick 9. The Psychiatric Genomics Consortium: History, development, and the future Hunna J. Watson, Zeynep Yilmaz and Patrick F. Sullivan 10. Statistical genetic concepts in psychiatric genomics Darina Czamara and Divya Mehta 11. Opportunities and challenges of machine learning approaches for biomarker signature identification in psychiatry Han Cao and Emanuel Schwarz 12. Personalized psychiatry with human iPSCs and neuronal reprogramming Cedric Bardy, Zarina Greenberg, Seth W. Perry and Julio Licinio 13. Genetics of alcohol use disorder Jill L. Sorcher and Falk W. Lohoff 14. Genomics of autism spectrum disorders Margarita Raygada, Paul Grant and Owen M. Rennert 15. Genomics of schizophrenia A. Corvin, C. Ormond and A.M. Cole 16. Genomics of major depressive disorder Douglas F. Levinson 17. Personalized mental health: Artificial intelligence technologies for treatment response prediction in anxiety disorders Ulrike Lueken and Tim Hahn 18. The genetic architecture of bipolar disorder: Entering the road of discoveries Olav B. Smeland, Andreas J. Forstner, Alexander Charney, Eli A. Stahl and Ole A. Andreassen 19. Genomics of borderline personality disorder Fabian Streit, Luci�a Colodro-Conde, Alisha S.M. Hall and Stephanie H. Witt 20. Genetics of obsessive-compulsive disorder and Tourette disorder Christie L. Burton, Csaba Barta, Danielle Cath, Daniel Geller, Odile A. van den Heuvel, Yin Yao, (Obsessive Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium), Valsamma Eapen, Edna Gr�nblatt and Gwyneth Zai 21. Genetics and pharmacogenetics of attention deficit hyperactivity disorder in childhood and adulthood Cristian Bonvicini, Carlo Maj and Catia Scassellati 22. Genomics of Alzheimer's disease Margot P. van de Weijer, Iris E. Jansen, Anouk H.A. Verboven, Ole A. Andreassen and Danielle Posthuma 23. Current progress and future direction in the genetics of PTSD: Focus on the development and contributions of the PGC-PTSD working group Angela G. Junglen, Christina Sheerin, Douglas L. Delahanty, Michael A. Hauser, Adriana Lori, Rajendra A. Morey, Caroline M. Nievergelt, Nicole R. Nugent, Jonathan Sebat, Alicia K. Smith, Jennifer A. Sumner, Monica Uddin and Ananda B. Amstadter 24. Genomic contributions to anxiety disorders Shareefa Dalvie, Nastassja Koen and Dan J. Stein 25. Proteomics for diagnostic and therapeutic blood biomarker discovery in schizophrenia and other psychotic disorders David R. Cotter, Sophie Sabherwal and Klaus Oliver Schubert 26. Molecular biomarkers in depression: Toward personalized psychiatric treatment Anand Gururajan, John F Cryan and Timothy G Dinan 27. Neuroimaging biomarkers of late-life major depressive disorder pathophysiology, pathogenesis, and treatment response Helmet T. Karim, Charles F. Reynolds, III and Stephen F. Smagula 28. Copy number variants in psychiatric disorders Franziska Degenhardt 29. Gene-environment interaction in psychiatry Hans J�rgen Grabe and Sandra Van der Auwera 30. Epigenetics: A new approach to understanding mechanisms in depression and to predict antidepressant treatment response Helge Frieling, Stefan Bleich and Alexandra Neyazi 31. Gene coexpression network and machine learning in personalized psychiatry Liliana G. Ciobanu, Micah Cearns and Bernhard T. Baune 32. Pharmacogenomics of bipolar disorder Claudia Pisanu, Alessio Squassina, Martin Alda and Giovanni Severino 33. Pharmacogenomics of treatment response in major depressive disorder Joanna M. Biernacka, Ahmed T. Ahmed, Balwinder Singh and Mark A. Frye 34. Genomic treatment response prediction in schizophrenia Sophie E. Legge, Antonio F. Pardi�as and James T.R. Walters 35. Personalized treatment in bipolar disorder Estela Salagre, Eduard Vieta and Iria Grande 36. Genetic testing in psychiatry: State of the evidence Chad A. Bousman, Lisa C. Brown, Ajeet B. Singh, Harris A. Eyre and Daniel J. M�ller 37. Opportunities and challenges of implementation models of pharmacogenomics in clinical practice Jonathan C.W. Liu, Ilona Gorbovskaya, Chad Bousman, Lisa C. Brown and Daniel J. M�ller 38. Metabolomics in psychiatry Renee-Marie Ragguett and Roger S. McIntyre 39. Real-time fMRI brain-computer interface: A tool for personalized psychiatry? David E.J. Linden 40. How functional neuroimaging can be used for prediction and evaluation in psychiatry Beata R. Godlewska and Catherine J. Harmer 41. Neuroimaging, genetics, and personalized psychiatry: Developments and opportunities from the ENIGMA consortium Lianne Schmaal, Christopher R.K. Ching, Agnes B. McMahon, Neda Jahanshad and Paul M. Thompson 42. Applying a neural circuit taxonomy in depression and anxiety for personalized psychiatry Leanne M. Williams and Andrea N. Goldstein-Piekarski 43. Multimodal modeling for personalized psychiatry Scott R. Clark, Micah Cearns, Klaus Oliver Schubert and Bernhard T. Baune 44. Standardized biomarker and biobanking requirements for personalized psychiatry Catherine Toben, Victoria K. Arnet, Anita Lo, Pamela H. Saunders and Bernhard T. Baune 45. Ethical, policy, and research considerations for personalized psychiatry Ryan Abbott, Donald D. Chang and Harris A. Eyre 46. The future of personalized psychiatry Bernhard T. Baune

Authors

Bernhard Baune 1. Department of Psychiatry and Psychotherapy, University of M�nster, M�nster, Germany
2. Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Parkville, VIC, Australia
3. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia. Prof. Bernhard Baune (PhD, MD, MPH, FRANZCP) is the Director of the University Hospital Department of Psychiatry and Psychotherapy, University of M�nster, Germany. He also leads the newly established Laboratory Division of Molecular Neurobiology of Mental Health at the University. Prof. Baune has been the Cato Chair and Head of Department of Psychiatry at the University of Melbourne, Australia prior to being awarded the Director position at the University of M�nster. Prof. Baune is a Fellow of the Royal Australian and New Zealand College of Psychiatrist (FRANZCP), he is a Professorial Fellow of the Department of Psychiatry, University of Melbourne and also at the Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia.

Prof. Baune is known for his extensive research program into depression and cognitive dysfunction, personalised psychiatry, molecular psychiatry, prediction and biomarker research and treatment response research as well as for key research achievements in the field of immune-neurobiology of psychiatric disorders.

Prof. Baune's translational work at the University of M�nster is designed to make real-world differences to the lives of people with mental illness by integrating neurobiological and clinical information, by personalising treatments and by targeting the mechanisms of functional recovery.

Other related work include the leadership of an international consortium on the genomics of severe depression and response to ECT in affective disorders (GenECT-ic), leading an international study on the genomics of cognitive function in depression and directing the ECNP network on trans- diagnostic pharmacogenomics and transcriptomics in psychiatric disorders.

His research is nationally and internationally recognised and he has published more than 500 peer-reviewed articles, reviews and book chapters, and he edited several text books in Psychiatry, and most recently the books "Personalised Psychiatry� (Elsevier), "Inflammation and Immunity of Depression� (Elsevier) and "Cognitive Dimensions of Major Depressive Disorder� (Oxford University Press).