Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine.
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Table of Contents
1. From Mendelian Genetics to 4D-Genomics2. Genes and Genomes Represent Different Biological Entities
3. Genome Chaos and Macro-cellular Evolution: How Evolutionary Cytogenetics Unravels the Mystery of Cancer
4. Chromosomal Coding and Fuzzy Inheritance
5. Why sex? Genome Re-interpretation Dethrones the Queen
6. Breaking the Genome Constraint: The Mechanism of Macro-evolution
7. The Genome Theory: A New Framework
8.�The Rationale and Challenges for Precision Medicine