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Global In Vitro Toxicology Testing Market – Drivers, Restraints, Opportunities, Trends, and Forecast: 2018–2024
Overview: In vitro toxicology involves the study of cells or tissues grown or maintained in precise lab conditions to observe the toxic properties of the compound. These testing methods help in inspecting the toxicity of xenobiotics at the cellular level in the laboratory without the interaction of complex physiological systemic effects that are often observed in living organisms. In vitro methods are commonly used in recent years as these can be correlated with in vivo studies and assist in understanding a particular in vivo response in any animal species. It is commonly employed by the pharmaceutical, chemical, food, cosmetic, medical device, and diagnostics industries to test the safety (toxicity) and efficacy of drugs, chemicals, biochemicals, materials, and preparations. Most of the information about the potential toxicity of drug substances are obtained from using animal models, but these tend to have significant limitations when translating them to human risk assessment. Although some basic toxicity testing using human cells in vitro is already a conventional method, many toxicologists are developing more sophisticated in vitro analyses using human-based cell models that can be more predictive about human health outcomes.
The market for in vitro toxicology testing is driven by high opposition to animal testing, increased cost related to animal-based toxicity testing, and increasing R&D expenditure for early stage toxicity testing. Whereas, the lack of in vitro models and decreased adoption rate are limiting the growth of the market to an extent.
Market Analysis: The “global in vitro toxicology testing market” is estimated to witness a CAGR of 8.2% during the forecast period 2018–2024. The global market is analyzed based on three segments – toxicology endpoints, industry type, and regions.
Regional Analysis: The regions covered in the report are North America, Europe, Asia Pacific, and Rest of the World (ROW). Europe is the major shareholder in the global in vitro toxicology testing market, followed by North America. The upsurge in the investments by the European Commission in R&D to develop substitute methods to in vivo testing is driving the demand in this region. Asia Pacific is expected to grow at a high CAGR during the forecast period due to increasing number of contract research organizations offering testing services, advancements in healthcare infrastructure, increasing investments in the biopharmaceutical sector, and upward economic conditions in this region.
Toxicology Endpoints Analysis: The in vitro toxicology testing market, by toxicology endpoints, is segmented into systemic toxicity, cytotoxicity testing, genotoxicity testing, ocular toxicity, organ toxicity, dermal toxicity, neurotoxicity, and others. Among these, systemic toxicity accounted for the highest market share in 2017 due to the availability of a wide range of sub-studies, which ensure total analysis of toxicity and safety margin of the testing compounds.
Industry Type Analysis: The in vitro toxicology testing market, by industry type, is segmented into pharmaceutical and biopharmaceutical, cosmetics, chemical, diagnostics, and food industry. The pharmaceutical and biopharmaceutical industry occupied significant market share in 2017 and the cosmetics industry is expected to hold a higher percentage during the forecast period. Increased support of regulatory authorities to use in vitro and in silico methods instead of animal testing to check toxicology is driving the growth of the cosmetic industry.
Key Players:
Laboratory Corporation of America Holdings, Charles River Laboratories, Inc., Bio-Rad Laboratories, GE Healthcare, Thermo Fisher Scientific, Eurofins Scientific, SGS SA, BioIVT, Agilent Technologies, Inc., Abbott Laboratories, Gentronix Limited, Promega Corporation, MB Research Laboratories, Evotec AG (Cyprotex plc), Catalent, Inc., Qiagen N.V., and niche players.
Competitive Analysis: There is an increase in collaborations between companies on in vitro testing of compounds. For instance, in December 2016, Evotec and Celgene entered into a drug discovery collaboration for neurodegenerative diseases. According to agreement terms, Celgene will use Evotec's unique induced pluripotent stem cell (iPSC) platform that enables systematic drug screening in patient-derived disease models. In June 2017, Censo Biotechnologies Ltd. collaborated with Evotec AG to source and provide patient-derived induced pluripotent stem cells to support Evotec’s drug discovery iPSC platform. In addition, the companies are also coming up with new products for in vitro testing. For instance, in January 2018, STEMCELL Technologies Inc. released two product lines for organoid research that will enable scientists to create powerful models for studying human disease in the lab.
Benefits: The report provides complete details about the services offered by in vitro toxicology testing companies in various therapeutic verticals and regions. With that, key stakeholders can know about the major trends, drivers, investments, and vertical player’s initiatives. Moreover, the report provides details about the major challenges that are going to impact on the market growth. Additionally, the report gives the complete details about the key business opportunities to key stakeholders to expand their business and capture the revenue in the specific verticals to analyze before investing or expanding the business in this market.
Table of Contents
1 Industry Outlook
1.1 Industry overview
1.2 Importance of toxicology studies
2 Report Outline
2.1 Report Scope
2.2 Report Summary
2.3 Research Methodology
2.4 Report Assumptions
3 Market Snapshot
3.1 Market Definition
3.2 Advantages of In vitro testing
3.3 Segmented Addressable Market (SAM)
3.4 Trends of the in vitro toxicology testing market
3.5 Related Markets
3.5.1 In vivo toxicology
3.5.2 ADME Toxicology testing
3.5.3 Biologics safety testing
4 Market Outlook
4.1 Market segmentation
4.2 PEST Analysis
4.3 Porter 5(Five) Forces
5 Market Characteristics
5.1 DRO – Global In Vitro Toxicology Testing Market Dynamics
5.1.1 Drivers
5.1.1.1 High opposition to animal testing
5.1.1.2 Low cost associated with in vitro toxicology testing
5.1.2 Opportunities
5.1.2.1 Advent of new in vitro models
5.1.2.2 Upsurge in toxicology database will facilitate the use of in vitro testing methods
5.1.3 Restraints
5.1.3.1 Barriers in adopting in vitro testing methods
5.1.3.2 Deficiency of in vitro models to conduct complex studies
5.2 DRO – Impact Analysis
5.3 Key Stakeholders
6 Toxicity endpoints: Market Size and Analysis
6.1 Overview
6.2 Systemic toxicity testing
6.3 Cytotoxicity testing
6.4 Genotoxicity testing
6.5 Organ toxicity
6.6 Ocular toxicity
6.7 Dermal toxicity
6.8 Neurotoxicity
6.9 Others
7 Industry type: Market Size and Analysis
7.1 Overview
7.2 Pharma and biopharma industry
7.3 Cosmetics industry
7.4 Chemical industry
7.5 Food industry
7.6 Diagnostics industry
8 Regions: Market Size and Analysis
8.1 Overview
8.2 North America
8.3 Europe
8.4 Asia Pacific
8.5 Rest of the World
9 Competitive Landscape
9.1 Overview
10 Vendor Profiles
10.1 Laboratory Corporation of America Holdings (LABCORP)
10.1.1 Overview
10.1.2 Laboratory Corporation of America Holdings: Recent Developments
10.1.3 Business Units
10.1.4 Geographic Revenue
10.1.5 Business Focus
10.1.6 SWOT Analysis
10.1.7 Business Strategies
10.2 Charles River Laboratories, Inc.
10.2.1 Overview
10.2.2 Charles River Laboratories, Inc.: Recent Developments
10.2.3 Business Units
10.2.4 Geographic Revenue
10.2.5 Business Focus
10.2.6 SWOT Analysis
10.2.7 Business Strategies
10.3 Thermo Fisher Scientific, Inc.
10.3.1 Overview
10.3.2 Business Units
10.3.3 Geographic Revenue
10.3.4 Business focus
10.3.5 SWOT analysis
10.3.6 Business Strategy
10.4 Eurofins Scientific
10.4.1 Overview
10.4.2 Geographic Revenue
10.4.3 Business focus
10.4.4 SWOT analysis
10.4.5 Business Strategy
10.5 Agilent Technologies Inc.
10.5.1 Overview
10.5.2 Business Units
10.5.3 Geographic Revenue
10.5.4 Business Focus
10.5.5 SWOT Analysis
10.5.6 Business Strategies
11 Companies to Watch For
11.1 SGS SA
11.1.1 Overview
11.2 Abbott Laboratories
11.2.1 Overview
11.3 GE Healthcare
11.3.1 Overview
11.4 BioReliance Corporation (a subsidiary of Merck KGaA)
11.4.1 Overview
11.5 BioIVT
11.5.1 Overview
11.6 Bio-Rad Laboratories
11.6.1 Overview
11.6.2 Bio-Rad Laboratories: Recent Developments
11.7 Catalent, Inc.
11.7.1 Overview
11.7.2 Catalent Inc: Recent Developments
11.8 Evotec AG (Cyprotex plc)
11.8.1 Overview
11.8.2 Evotec AG: Recent Developments
11.9 Gentronix Limited
11.9.1 Overview
11.9.2 Gentronix Limited: Recent Developments
11.10 Promega Corporation
11.10.1 Overview
11.10.2 Promega Corporation: Recent Developments
11.11 Qiagen N.V.
11.11.1 Overview
12 Annexure
12.1 Abbreviations
Tables
Table 1 Global In Vitro Toxicology Testing Market Revenue By Regions, 2017–2024 ($Million)
Table 2 Other Prominent Vendors Of In Vitro Toxicology Testing Market
Table 3 Laboratory Corporation Of America Holdings: Product Offerings
Table 4 Charles River Laboratories, Inc.: Offerings
Table 5 Thermo Fisher Scientific, Inc.: Product Offerings
Table 6 Thermo Fisher Scientific, Inc: Recent Developments
Table 7 Eurofins Scientific: Product Offerings
Table 8 Eurofins Scientific: Recent Developments
Table 9 Agilent Technologies Inc: Product Offerings
Table 10 Agilent Technologies Inc: Recent Developments
Table 11 SGS SA: Snapshot
Table 12 Sgs SA: Recent Developments
Table 1 Abbott Laboratories: Snapshot
Table 2 Abbott Laboratories: Recent Developments
Table 3 GE Healthcare: Snapshot
Table 4 GE Healthcare: Recent Developments
Table 5 Bioreliance Corporation: Snapshot
Table 6 Bioreliance Corporation: Recent Developments
Table 7 Bioivt: Snapshot
Table 8 Bioivt: Recent Developments
Table 9 Bio-Rad Laboratories: Snapshot
Table 10 Catalent, Inc.: Snapshot
Table 11 Evotec AG: Snapshot
Table 12 Gentronix Limited: Snapshot
Table 13 Promega Corporation: Snapshot
Table 14 Qiagen N.V.: Snapshot
Table 15 Qiagen N.V.: Recent Developments
Charts
Chart 1 Research Methodology Of Global In Vitro Toxicology Testing Market
Chart 2 Global In Vitro Toxicology Testing Market Revenue, 2017–2024 ($Million)
Chart 3 Segmentation Of Global In Vitro Toxicology Testing Market
Chart 4 Pest Analysis Of Global In Vito Toxicology Testing Market
Chart 5 Porter 5 Forces On Global In Vitro Toxicology Testing Market
Chart 6 DRO – Impact Analysis Of Global In Vitro Toxicology Testing Market
Chart 7 Key Stakeholders
Chart 8 Global In Vitro Toxicology Testing Market By Toxicology Endpoints Segmentation, 2017 (%)
Chart 9 Global In Vitro Toxicology Testing Market By Industry Type Segmentation, 2017 (%)
Chart 10 Global In Vitro Toxicology Testing Market By Industry Type Segmentation, 2024 (%)
Chart 11 Global Pharma And Biopharma Industry Market Revenue Forecast, 2017–2024 ($Million)
Chart 12 Global Cosmetics Industry Market Revenue Forecast, 2017–2024 ($Million)
Chart 13 Global Chemical Industry Market Revenue Forecast, 2017–2024 ($Million)
Chart 14 Global Food Industry Market Revenue Forecast, 2017–2024 ($Million)
Chart 15 Global Diagnostics Industry Market Revenue Forecast, 2017–2024 ($Million)
Chart 16 Global In Vitro Toxicology Testing Market By Geographical Segmentation, 2017 (%)
Chart 17 In Vitro Toxicology Testing Market Revenue In North America, 2017–2024 ($Million)
Chart 18 In Vitro Toxicology Testing Market Revenue In Europe, 2017–2024 ($Million)
Chart 19 In Vitro Toxicology Testing Market Revenue In Asia Pacific, 2017–2024 ($Million)
Chart 20 In Vitro Toxicology Testing Market Revenue In Rest Of The World, 2017–2024 ($Million)
Chart 21 Laboratory Corporation Of America Holdings: Overview Snapshot
Chart 22 Laboratory Corporation Of America Holdings: Business Units Revenue
Chart 23 Laboratory Corporation Of America Holdings: Geographical Revenue
Chart 24 Laboratory Corporation Of Americal Holdings: Swot Analysis
Chart 25 Charles River Laboratories, Inc.: Overview Snapshot
Chart 26 Charles River Laboratories, Inc.: Business Units
Chart 27 Charles River Laboratories: Geographic Revenue
Chart 28 Charles River Laboratories, Inc.: Swot Analysis
Chart 29 Thermo Fisher Scientific: Overview Snapshot
Chart 30 Thermo Fisher Scientific, Inc.: Business Units
Chart 31 Thermo Fisher Scientific, Inc.: Geographic Revenue
Chart 32 Thermo Fisher Scientific, Inc.: Swot Analysis
Chart 33 Eurofins Scientific: Overview Snapshot
Chart 34 Eurofins Scientific: Geographic Revenue
Chart 35 Eurofins Scientific: Swot Analysis
Chart 36 Agilent Technologies Inc.: Overview Snapshot
Chart 37 Agilent Technologies, Inc.: Business Units
Chart 38 Agilent Technologies Inc.: Geographic Revenue
Chart 39 Agilent Technologies, Inc.: Swot Analysis
Companies Mentioned
- Abbott Laboratories
- Agilent Technologies Inc.
- America Holdings
- Bio-Rad Laboratories
- BioIVT
- Catalent Inc.
- Charles River Laboratories Inc.
- Eurofins Scientific
- Evotec AG (Cyprotex plc)
- GE Healthcare
- Gentronix Limited
- MB Research Laboratories
- Promega Corporation
- Qiagen N.V.
- SGS SA
- Thermo Fisher Scientific
