Alzheimer’s Disease (AD) is the product of the slow and progressive degenerative alteration that develops in the adult brain and can remain asymptomatic for a considerable time before cognitive deficits becomes evident. The main challenge for researchers is to identify markers of this degenerative process, and, in this sense, data has been generated through experiments bringing to light new mechanisms and hypothesis to explain its pathophysiology.
This book is a review of recent studies in AD molecular biology. Chapters explain various facets of AD, which include animal models, morphological changes, membrane composition, amyloidogenic peptides, intracellular transport systems, and the role of oxidative stress and calcium deregulation.
Readers will understand the molecular mechanisms behind AD and therefore broaden their perspective on this neurodegenerative disease and its progression.
Table of Contents
Chapter 1 Differences And Implications Of Animal Models For The Study Of Alzheimer's Disease
Chapter 2 Micro and Macro Morphologic Changes in Alzheimer’s Disease
Chapter 3 Alterations of Membrane Composition in Alzheimer's Disease
Chapter 4 Amyloidogenic Peptide Structure, Aggregation, and Membrane Interaction
Chapter 5 Intracellular Transport System in AD
Chapter 6 Alzheimer's Disease and Oxidative Stress
Chapter 7 Calcium Deregulation in Alzheimer’s Disease
Conflict of Interests
Acknowledgement
References
Subject Index
Author
Fernando A. Oliveira
