- New content with over 20 new chapters covering idiopathic non-lupus full-house nephropathy, hemophagocytic glomerulonephritis, cryofibrinogenemic glomerulopathy, metabolic syndrome and obesity-related glomerular disease, Whipple disease, systemic Castleman disease, nephropathies due to direct acting antivirals for HCV, checkpoint inhibitors, EGFR antagonists, illicit drugs and opioids, Tums glomerulopathy, vancomycin-induced cast nephropathy, transcript analysis of renal biopsies, new forms of amyloidosis, and mass spectroscopy - Updated and validated pathologic classifications systems reflect details on new genetic, therapeutic, and pathologic information, including IgA nephropathy, lupus nephritis, vasculitis, and transplant pathology - More than 3,300 outstanding, annotated images, including gross and microscopic pathology, a wide range of stains, and detailed medical illustrations, make this an invaluable diagnostic aid for every practicing pathologist, nephrologist, resident, or fellow - Time-saving reference features include consistently templated chapters, bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index - Internationally recognized authors, many new to this edition, provide fresh perspectives on multiple topics, with a particular emphasis on practical information that directly assists in making and supporting a diagnosis - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices
Table of Contents
Introduction
Introduction and Overview
Introduction to Renal Pathology
Normal Kidney Structure
Normal Kidney Development
Glomerular Diseases
Podocytopathies
Minimal Change Disease
Classification of FSGS
Etiologic Classification of FSGS
FSGS, Primary
FSGS, Adaptive (Secondary)
Collapsing Glomerulopathy
Membranous Glomerulonephritis
Etiologic Classification of Membranous Glomerulonephritis
Membranous Glomerulonephritis, Primary
Membranous Glomerulonephritis, Secondary
Membranous Glomerulonephritis With Anti-TBM Antibodies
C3-Related Glomerulonephritis and Membranoproliferative Glomerulonephritis
Classification of MPGN and Complement-Related Diseases
Dense Deposit Disease
C3 Glomerulonephritis
Membranoproliferative Glomerulonephritis With Immune Complexes
IgA-Related Glomerulonephritis
Overview of IgA-Related Glomerulopathies
IgA Nephropathy
IgA Vasculitis (Henoch-Sch�nlein Purpura)
SLE and Related Autoantibody-Mediated GN
Systemic Lupus Erythematosus
Mixed Connective Tissue Disease
Rheumatoid Arthritis
Mixed Cryoglobulinemic Glomerulonephritis
Idiopathic Nonlupus Full-House Nephropathy
Anti-GBM Nephritis
Anti-GBM Glomerulonephritis
Atypical Anti-GBM Nephritis
Monoclonal Immunoglobulin Diseases
Introduction to Diseases With Monoclonal Immunoglobulin Deposits
Monoclonal Immunoglobulin Deposition Disease
Proliferative Glomerulonephritis With Monoclonal IgG Deposits
Membranous Glomerulonephritis With Masked IgG ? Deposits
Type I Cryoglobulinemic Glomerulonephritis
Waldenstr�m Macroglobulinemia
Amyloidosis
Amyloidosis Classification
AL/AH Amyloidosis
AA Amyloidosis
AFib Amyloidosis
AGel Amyloidosis
ALECT2 Amyloidosis
AApoAI Amyloidosis
ApoAII Amyloidosis
AApoAIV Amyloidosis
AApoCII Amyloidosis
ATTR Amyloidosis
Idiopathic Fibrillary Glomerulopathies
Diseases With Organized Deposits
Fibrillary Glomerulopathy
Immunotactoid Glomerulopathy
Fibronectin Glomerulopathy
Diabetic Renal Disease
Diabetic Nephropathy
Idiopathic Nodular Glomerulopathy
Infection-Related Glomerular Disease
Overview of Infection-Related Glomerular Disease
Acute Poststreptococcal Glomerulonephritis
Acute Postinfectious Glomerulonephritis, Nonstreptococcal
IgA Acute Glomerulonephritis Associated With *Staphylococcus aureus*
Glomerulonephritis of Chronic Infection, Including Shunt Nephritis
Endocarditis
Syphilis
Lyme Disease
Hepatitis B Virus
Hepatitis C Virus
HIV-Associated Nephropathy
Miscellaneous HIV-Associated Renal Diseases
Schistosomiasis
Filariasis
Leishmaniasis
Drug Induced Glomerular Diseases
Drug-Induced Minimal Change Disease
Bisphosphonate-Induced Collapsing Glomerulopathy
Chloroquine Toxicity
Anti-Hepatitis C Virus Drugs
Anti-EGFR Drugs
Genetic Diseases of the Glomerulus
Overview and Classification of Genetic Diseases of the Glomerulus
Genetic Diseases of the Glomerular Basement Membrane Collagen
Alport Syndrome
Thin Basement Membrane Disease
Genetic Diseases of the Podocyte
Diffuse Mesangial Sclerosis
Congenital Nephrotic Syndrome of the Finnish Type
Pierson Syndrome
Galloway-Mowat Syndrome
Denys-Drash Syndrome
Frasier Syndrome
Podocin Deficiency
Alpha-Actinin-4 Deficiency
Autosomal Dominant FSGS Due to *INF2* Mutations
*APOL1*-Related Glomerular Disease
Schimke Immuno-Osseous Dysplasia
Genetic Storage and Lipid Diseases
Lecithin-Cholesterol Acyltransferase Deficiency
APOE Lipoprotein Glomerulopathy
Type III Hyperlipoproteinemia
Fabry Disease
Gaucher Glomerulopathy
I-Cell Disease (Mucolipidosis II)
Alagille Syndrome
Other Genetic Diseases Affecting the Glomerulus
Glomerulopathy of Hereditary Multiple Exostoses
Type III Collagen Glomerulopathy
Nail-Patella Syndrome
Miscellaneous Glomerular Diseases
C1q Nephropathy
IgM Nephropathy
Cryofibrinogenic Glomerulopathy
Hepatic Glomerulosclerosis and IgA Deposition
Hemophagocytic Glomerulopathy
Podocyte Infolding Glomerulopathy
Metabolic Syndrome/Obesity-Related Glomerular Disease
Intravascular Large B-Cell Lymphoma
Vascular Diseases
Overview and Classification of Systemic Vasculitides
ANCA Disease
ANCA-Related Glomerulonephritis
Microscopic Polyangiitis
Granulomatosis With Polyangiitis
Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)
Drug-Induced ANCA Vasculitis
Non-ANCA Vasculitides
Polyarteritis Nodosa
Kawasaki Disease
Giant Cell Arteritis
Takayasu Arteritis
Hypocomplementemic Urticarial Vasculitis (Anti-C1q Vasculitis)
Thrombotic Microangiopathies
Introduction to Thrombotic Microangiopathies
Hemolytic Uremic Syndrome, Infection Related
Thrombotic Microangiopathy, Genetic
Thrombotic Microangiopathy, Autoimmune
Thrombotic Microangiopathy, Drug Induced
Postpartum Hemolytic Uremic Syndrome
Scleroderma Renal Disease
Multicentric Castleman Disease
Other Diseases Affecting the Endothelium
Preeclampsia, Eclampsia, HELLP Syndrome
Radiation Nephropathy
Glomerulopathy of Hereditary Multiple Extoses
Sickle Cell Nephropathy
Hypertensive Renal Disease
Hypertensive Renovascular Disease
Renal Artery Stenosis
Fibromuscular Dysplasia
Neurofibromatosis
Thrombotic and Embolic Disease
Renal Vein Thrombosis
Renal Artery Thrombosis
Atheromatous Emboli
Hydrophilic Polymer Emboli
Tubulointerstitial Diseases
Overview and Classification of Tubulointerstitial Diseases
Differential Diagnosis of Acute Interstitial Nephritis
Ischemic Injury
Acute Tubular Injury
Renal Cortical Necrosis
Septicemia/Shock
Bile Cast Nephropathy
Immunologic Tubular Disease
Tubulointerstitial Nephritis With Uveitis
Sj�gren Syndrome
IgG4-Related Kidney Disease
Idiopathic Hypocomplementemic Tubulointerstitial Nephritis
Anti-Tubular Basement Membrane Disease
Antibrush Border Autoantibody Tubulointerstitial Nephritis
Sarcoidosis
Tubulointerstiital Nephritis with IgM+ Plasma Cells
Giant Cell Tubulitis With TBM Deposits
Monoclonal Immunoglobulin Diseases of Tubules
Light Chain Cast Nephropathy
Light Chain Proximal Tubulopathy With Crystals
Light Chain Proximal Tubulopathy Without Crystals
Drug-Induced Tubulointerstitial Diseases
Drug-Induced Acute Interstitial Nephritis
Drugs That Cause Tubulointerstitial Nephritis
Checkpoint Inhibitor-Induced Kidney Diseases
Papillary Necrosis
Myoglobinuria/Rhabdomyolysis/Hemoglobinuria
Cisplatin Nephrotoxicity
Osmotic Tubulopathy
Antiviral Drug Nephrotoxicity
Acute Phosphate Nephropathy
Lithium-Induced Renal Disease
Calcineurin Inhibitor Toxicity
mTOR Inhibitor Toxicity
Vancomycin-Induced Cast Nephropathy
Warfarin Nephropathy
Illicit Drugs and Opioids
Toxic Injury
Lead and Other Heavy Metal Toxins
Aristolochic Acid Nephropathy
Balkan Endemic Nephropathy
Ethylene Glycol Toxicity
Argyria
Autosomal Dominant Tubulointerstitial Kidney Disease
Autosomal Dominant Tubulointerstitial Kidney Disease, *MUC1*-Related
Autosomal Dominant Tubulointerstitial Kidney Disease, *UMOD*-Related
Autosomal Dominant Tubulointerstitial Kidney Disease, *REN*-Related
Autosomal Dominant Tubulointerstitial Kidney Disease, *HNF1B*-Related
Genetic Crystal Depostion Diseases
Primary Hyperoxaluria
2,8-Dihydroxyadeninuria
Cystinosis
Uric Acid Nephropathy/Gout
Genetic Transport Diseases
Bartter Syndrome
Dent Disease
Oculocerebrorenal Syndrome of Lowe
Other Genetic Diseases Affecting Tubules
Methylmalonic Acidemia
Systemic Karyomegaly
Mitochondriopathies
Miscellaneous Tubulointerstitial Diseases
Nephrocalcinosis
Secondary Oxalosis
Mesoamerican Nephropathy
Extramedullary Hematopoiesis
Infections of the Kidney
Bacterial Infections of the Kidney
Acute Pyelonephritis
Chronic Pyelonephritis
Xanthogranulomatous Pyelonephritis
Malakoplakia
Tuberculosis
BCG Granulomatous Interstitial Nephritis
Leprosy
Megalocytic Interstitial Nephritis
Nocardiosis
Leptospirosis
Whipple Disease
Fungal, Rickettsial, and Parasitic Infections of the Kidney
Mucormycosis
Candidiasis
Histoplasmosis
Coccidioidomycosis
Blastomycosis
Paracoccidioidomycosis
Aspergillosis
Cryptococcosis
Microsporidiosis
Rickettsial Infections
Toxoplasmosis
Hydatidosis
Viral Infections of the Kidney
Polyomavirus Nephritis
Cytomegalovirus Infection
Adenovirus Infection
Epstein-Barr Virus Nephritis
Herpes Simplex Acute Nephritis
Hantavirus Nephropathy
Developmental Diseases
Overview of Congenital Anomalies of the Kidney and Urinary Tract
Dysplasia/Hypoplasia/Agenesis
Oligomeganephronia
Ectopia, Malrotation, Duplication, Fusion, Supernumerary Kidney
Ask-Upmark Kidney
Renal Tubular Dysgenesis
Cystic Diseases
Overview of Cystic Diseases
Ciliopathies
Autosomal Dominant Polycystic Kidney Disease
Autosomal Recessive Polycystic Kidney Disease
Nephronophthisis and Related Ciliopathies
Other Genetic Cystic Diseases
von Hippel-Lindau Disease
Tuberous Sclerosis Complex
Zellweger Syndrome
Miscellaneous Cystic Diseases
Medullary Sponge Kidney
Mixed Epithelial and Stromal Tumor Family
Pediatric Cystic Nephroma
Acquired Cystic Disease
Simple and Miscellaneous Cysts
Renal Lymphangioma/Lymphangiectasia
Diseases of the Collecting System
Introduction to Impediments to Urine Flow
Reflux Nephropathy
Obstructive Nephropathy
Nephrolithiasis
Loin Pain Hematuria Syndrome
Diseases of the Renal Allograft
Pathologic Classification of Renal Allograft Diseases
Introduction
Evaluation of Allograft Kidney
Evaluation of the Donor Kidney
Rejection
Acute T-Cell-Mediated Rejection
Chronic T-Cell-Mediated Rejection
Hyperacute Rejection
Acute Antibody-Mediated Rejection
Chronic Antibody-Mediated Rejection
Transcript Analysis of Renal Transplant Biopsies
Recurrent and De Novo Diseases
Diseases That Recur in Allografts
De Novo FSGS
De Novo Membranous Glomerulonephritis
Anti-GBM Disease in Alport Syndrome
Engraftment Syndrome
Nonimmunologic Injury
Acute Allograft Ischemia
Hyperperfusion Injury
Urine Leak
Lymphocele
Transplant Renal Artery Stenosis
Renal Artery or Vein Thrombosis
Posttransplant Lymphoproliferative Disease
BK Polyomavirus Neoplasia
Stable and Accepted Grafts
Protocol Biopsies
Accommodation
Tolerance
Kidney Pathology in Recipients of Other Transplants
Kidney Diseases in Nonrenal Transplant Recipients
Graft-vs.-Host Glomerulopathies
Protocols
Biopsy Reports
Kidney Needle Biopsy: Evaluation for Adequacy
Evaluation of Fibrosis
Immunofluorescence on Paraffin Tissue Sections
EM Processing From Paraffin or Frozen Tissue
Detection of PLA2R Deposits and Autoantibodies
Alport Collagen IV Immunofluorescence
C4d Immunohistochemistry/Immunofluorescence
Polyomavirus Detection in Tissue
Mass Spectrometry
Diagnostic Genetics of Kidney Diseases
Examination of the End-Stage Kidney
Examination of Tumor Nephrectomy Specimens for Nonneoplastic Diseases
Evaluation of the Transplant Nephrectomy
Evaluation of Autopsy Kidneys
