Principles of Nutrigenetics and Nutrigenomics. Fundamentals of Individualized Nutrition

Table of Contents

Section 1: The biological basis of heritability and diversity 1. The nature of traits, genes�and variation 2. Molecular biology of genetic variants 3. Regulation of Gene Expression 4. The role of nutrition in DNA replication, DNA damage prevention and DNA repair 5. Genotyping and sequencing 6. RNA analyses 7. Methods in Nutrigenomics for precision nutrition 8. Epigenetics: Methodology and tools for nutrition research 9. Proteomic analyses 10. Metabolomic analyses 11. Metagenomics 12. A Broader View on Omics and Systems Biology 13. Study design in genomic epidemiology 14. Epistemology of nutrigenetic knowledge

Section 2: Nutrigenetics 15. Nutrigenetics and the early life origins of health and disease: effects of protein restriction 16. Perinatal nutrition 17. Epigenetics Mechanisms 18. Genetics of Chrononutrition 19. Newborn screening 20. Genomics of Eating Behavior and Appetite Regulation 21. Genetics of Body Composition: From Severe Obesity to Extreme Leanness 22. Genetic regulation of energy homeostasis: obesity implications 23. Genetic variations in the response to weight-loss diets 24. Genetic variations in the response to exercise: impact on physical fitness and performance 25. Genetic variations impacting the response to defined diets 26. Carbohydrates 27. Monounsaturated and Saturated Fatty Acids 28. Omega-3 and omega-6 fatty acids 29. Blood cholesterol 30. Genetic Individuality and Alcoholic Consumption 31. Vitamin A and other carotenoids 32. Vitamin D 33. Vitamin E 34. Vitamin K 35. Vitamins as Cofactors for Energy Homeostasis: Biotin, Thiamine and Pantothenic Acid 36. Vitamin C 37. Vitamin B2 38. Niacin 39. Folate, vitamin B6, vitamin B12 40. Choline 41. Electrolytes 42. Iron 43. Trace elements 44. Polyphenols and Nutrigenetic/Nutrigenomic Associations with Obesity-Related Metabolic Diseases 45. Caffeine 46. Phytanic acid 47. Cognitive function 48. Cardiovascular Disease 49. Hemostasis and thrombosis 50. Diabetes mellitus 51. Bone health 52. Nutrients and Genes in the Liver 53. Hyperuricemia and gout 54. Aging 55. Epigenetics in food allergies: the missing piece of the puzzle 56. Gut microbiota and their influence on the response to foods

Section 3: Nutrigenomics 57. Nutrients and Gene Expression in Development 58. Nutrients and gene expression in Obesity 59. Nutrients and gene expression in Diabetes 60. Gene expression in dyslipidemias 61. Nutrients and gene expression in Inflammation 62. Nutrients and gene expression in Cardiovascular Disease 63. Nutrients and Gene Expression in Cancer 64. Nutrients and Gene Expression Affecting Bone Metabolism

Section 4: Translational nutrigenetics and nutrigenomics 65. Nutrigenetics-based intervention studies 66. Genome-based nutrition guidance 67. Nutrigenomics of food pesticides 68. Pharmaconutrigenetics: the impact of genetics on nutrient-drug interactions 69. Setting genome-directed guidelines and algorithms 70. Direct-to-consumer services 71. Privacy risks and protective measures 72. Ethical considerations in nutrigenetics and nutrigenomics 73. Impact of Nutrigenetics and Nutrigenomics on Society

Authors

Raffaele De Caterina University Cardiology Division, University of Pisa, Pisa, Italy. Raffaele De Caterina is a Professor of Cardiology at the University of Pisa and Director of the University Cardiology Division at Pisa University Hospital, Pisa, Italy. He has been President of the International Society on Nutrigenetics/Nutrigenomics (2009-2013) and vice-President of the European Society of Cardiology (2008-2010). He is Editor-in-Chief of the journal Vascular Pharmacology and author of over 600 peer-reviewed manuscripts. His major research interests include cardiovascular pharmacology, atrial fibrillation, coronary artery disease, and cardiovascular thrombosis, as well as nutrigenetics and nutrigenomics. J. Alfredo Martinez Department of Nutrition, University of Navarra, Pamplona, Spain
IMDEA food (CEI UAM + CSIC) and CIBERobn, Madrid, Spain. Prof. J. Alfredo Mart�nez has been involved in several landmark intervention trials and more than 50 national and international projects. He has supervised more than 70 PhD students and published more than 800 peer-reviewed manuscripts and book chapters in the areas of obesity and personalized nutrition, including precision nutritional omics. His works have been cited more than 26,000 times, and his HFactor is over 64. He has been President of the International Society of Nutrigenetics/Nutrigenomics (2015-2017) and is President of the International Union of Nutritional Sciences (IUNS) for the 2017-2021 period. Prof. Mart�nez has enjoyed training or invited stays at the University of Nottingham, Berkeley College, MIT, Harvard University, Oxford University, and King's College London. He has been an advisor for EU Projects or a guest speaker or main keynote lecturer in important forums concerning precision nutrition in obesity and cardiometabolic diseases, including IUNS, ISNN, OMS, FAO, IAEA, NIH, SLAN, and FENS. Martin Kohlmeier UNC Nutrition Research Institute, and Department of Nutrition, University of North Carolina School of Medicine and Gillings School of Global Public Health, Chapel Hill, NC, USA. Dr. Martin Kohlmeier, MD, PhD, is a Professor of Nutrition; Director of the Human Research Core and the Nutrigenetics Laboratory at the UNC Nutrition Research Institute in Kannapolis, NC; Director of Nutrition in Medicine for online nutrition education of medical students and health professionals; visiting fellow of Wolfson College at Cambridge University, UK; founding Editor-in-Chief of BMJ Nutrition, Prevention and Health; and President of the International Society of Nutrigenetics/Nutrigenomics (ISNN). His professional interests include investigating genotype-specific nutrition responses of humans in health and disease, developing decision-support algorithms and tools for precision nutrition, and teaching health care professionals how to use nutrigenetics in practice. His previously authored textbooks in the field include Nutrigenetics (Academic Press, 2013) and Nutrient Metabolism (2nd Edition, Academic Press, 2015).