Chronic Renal Disease, Second Edition, comprehensively investigates the physiology, pathophysiology, treatment and management of chronic kidney disease (CKD). This translational reference takes an in-depth look at CKD with no coverage of dialysis or transplantation. Chapters are devoted to the scientific investigation of chronic kidney disease, the most common problems faced by nephrologists in the management of chronic kidney disease, specific illnesses in the CKD framework, and how the management of CKD in a polycystic kidney disease patient differs from other CKD patients. This award-winning reference features a series of case studies, covering both clinical aspects and pathophysiology.
Questions are open ended, progressively more difficult, and repetitive across different patient clinical problems and different chapters. The cases and questions included will be useful for medical students, residency board reviews, and clinician teaching or conference preparation.
Table of Contents
I INTRODUCTION 1. Introduction
II CLASSIFICATION AND MEASUREMENT 2. From Bright's Disease to Chronic Kidney Disease 3. Classification of Chronic Kidney Disease Historic Perspective: From Insufficiency and Failure to Chronic Kidney Disease 4. Assessing Kidney Function 5. Clinical Assessment and Management of Chronic Kidney Disease Across Its Stages
III EPIDEMIOLOGY 6. Epidemiology of Chronic Kidney Disease Scope of the Problem 7. Gender Issues in Chronic Kidney Disease 8. Ethnicity and Chronic Kidney Disease United States 9. Ethnicity and Chronic Kidney Disease in Disadvantaged Populations An International Perspective 10. Ethnicity and Chronic Kidney Disease in Japan 11. Ethnicity and Chronic Kidney Disease in Africa 12. Ethnicity and Chronic Kidney Disease in China 13. Poverty and Chronic Kidney Disease
IV PATHOPHYSIOLOGY 14. The Uremic Syndrome 15. Pathophysiology of Proteinuria: Albuminuria as a Target for Treatment 16. Protein Energy Metabolism in Chronic Kidney Disease 17. Aging and the Kidney: Clinical and Pathophysiologic Issues 18. Pathophysiology of Chronic Kidney Disease Progression: Organ and Cellular Considerations 19. Pathophysiology of Diabetic Nephropathy 20. Prenatal Antecedents of Chronic Kidney Disease 21. Pathophysiology of Hypertension in Chronic Kidney Disease 22. Chronic Kidney Disease and the Vascular Endothelium 23. Cardiovascular Disease and Chronic Kidney Disease 24. Inflammation in Chronic Kidney Disease 25. Genetics and Chronic Kidney Disease 26. Acute Kidney Injury and Chronic Kidney Disease
V COMPLICATIONS OF CHRONIC KIDNEY DISEASE 27. Psychosocial Issues in Chronic Kidney Disease Patients 28. Ophthalmic Issues in Chronic Kidney Disease 29. Neurologic Complications of Chronic Kidney Disease 30. Hematologic Complications of Chronic Kidney Disease Anemia and Platelet Disorders 31. Hematologic and Infectious Complications of Chronic Kidney Disease 32. Immune Function in Chronic Kidney Disease 33. Chronic Kidney Disease and Gastrointestinal Disorders 34. Endocrine Complications of Chronic Kidney Disease 35. Chronic Kidney Disease Mineral and Bone Disorders 36. Sleep Disorders in Chronic Kidney Disease 37. Sexual Dysfunction in Chronic Kidney Disease
VI FLUID AND ELECTROLYTE DISORDERS IN CHRONIC KIDNEY DISEASE 38. Water Homeostasis in Chronic Kidney Disease 39. Sodium Metabolism in Chronic Kidney Disease 40. Potassium Metabolism in Chronic Kidney Disease 41. Calcium, Phosphate, and Magnesium Metabolism in Chronic Kidney Disease 42. Acid/Base Metabolism in Chronic Kidney Disease 43. Uric Acid Metabolism and the Kidney 44. Trace Elements in Chronic Kidney Disease
VII CHRONIC KIDNEY DISEASE AND SYSTEMIC ILLNESSES CLINICAL CONSIDERATIONS 45. Approach to the Patient with Chronic Glomerular Disease 46. Approach to the Patient with Hypertensive Nephrosclerosis 47. Approach to the Patient with Chronic Kidney Disease and Renovascular Disease 48. Polycystic Kidney Disease 49. Lupus Nephritis 50. Sickle Cell Disease 51. Approach to Chronic Kidney Disease in the Diabetic Patient 52. Human Immunodeficiency Virus Infection and Chronic Kidney Disease 53. Liver Disease and Chronic Kidney Disease 54. Chronic Kidney Disease and Heart Failure A Nephrologic Approach 55. Cancer and Chronic Kidney Disease
VIII THERAPEUTIC CONSIDERATIONS 56. The Interdisciplinary Clinic for Chronic Kidney Disease 57. Slowing Progression of Chronic Kidney Disease 58. Approach to the Patient with Non-nephrotic Proteinuria 59. Nutritional Management of Patients with Chronic Kidney Disease 60. Management of Anemia in Chronic Kidney Disease 61. Management of Hypertension in Chronic Kidney Disease 62. Management of Mineral and Bone Disorders in Chronic Kidney Disease 63. Drug Metabolism in Chronic Kidney Disease 64. Use of Diuretics in Chronic Kidney Disease Patients 65. Nonsteroidal Anti-inflammatory Drugs and Opioids in Chronic Kidney 66. Dyslipidemia and Chronic Kidney Disease 67. Nephrolithiasis, Nephrocalcinosis, and Hypercalciuria 68. Treatment of Psychiatric Disorders in Chronic Kidney Disease Patients 69. Preparing for Transplantation 70. Preparing for Hemodialysis 71. Preparing for Peritoneal Dialysis
IX SPECIAL CONSIDERATIONS 72. Emerging Therapies 73. The Renal Biopsy in Chronic Kidney 74. Pregnancy and Kidney Disease 75. Chronic Kidney Disease in Children 76. Reflux Nephropathy 77. Chronic Kidney Disease in the Elderly Who Has It? Who Does One Treat? and How are They to be Treated? 78. Pain and Chronic Kidney Disease 79. The Perioperative Management of the Patient with Chronic Kidney Disease 80. Ethical Issues in Chronic Kidney Disease Patients 81. Imaging the Chronic Kidney Disease Patient
Authors
Paul L. Kimmel Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, Washington, DC, United States. Paul L. Kimmel, MD, MACP, FRCP, FASN, was educated at Yale College and the New York University School of Medicine. He completed his internal medicine residency at Bellevue Hospital in New York City and Nephrology fellowship at the Hospital of the University of Pennsylvania. He was a member of the faculty at the University of Pennsylvania and the George Washington University, where he attained the rank of professor. From 2001 to 2006, Dr. Kimmel served as Director of the Division of Renal Diseases and Hypertension at George Washington University. From 2006 to 2008, he was the Director of Education of the American Society of Nephrology. Dr. Kimmel currently is Clinical Professor of Medicine at George Washington University in Washington, DC. His interests include psychosocial adaptation to chronic renal disease, sleep disorders in patients with kidney disease, zinc metabolism in renal diseases, HIV associated kidney diseases, the clinical genetics of common kidney disease, and the interrelationships between acute kidney injury and chronic kidney disease. Mark E. Rosenberg Professor of Medicine, Division of Renal Diseases and Hypertension; Vice Dean for Education, University of Minnesota Medical School, Minneapolis, Minnesota. Mark E. Rosenberg, MD, FASN, attended medical school at the University of Manitoba in Winnipeg, Canada, and did his internal medicine residency and nephrology fellowship at the University of Minnesota. He served as Director of the Division of Renal Diseases and Hypertension at the university from 2000 to 2009. From 2009 to 2012, he was the Chief of Medicine and Director of the Primary and Specialty Medicine Service Line at the Minneapolis VA Health Care System. Dr. Rosenberg currently serves as Vice Dean for Education and Academic Affairs, and Professor of Medicine at the University of Minnesota Medical School in Minneapolis,Minnesota. In this position, he is responsible for the continuum of medical education. He served as Chair of the Postgraduate Education Committee and
Education Director for Kidney Week for 6 years before being elected in 2013 to the Council of the American Society of Nephrology. Dr. Rosenberg served as President of the American Society of Nephrology in 2019. His interests include pathophysiology and progression of chronic kidney disease, kidney regeneration following acute injury, models of care delivery including telehealth, and workforce issues in nephrology.
