Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the body), genetics, pathology, radiology and pharmacology.
This book gives a thorough, detailed, yet concise account of the main bioscience, clinical and therapeutic aspects of tumors. It emphasizes the translational aspects of research into tumors with extensive discussions of interdisciplinary issues. The content in this book will be invaluable for researchers and clinicians involved in collaborative projects where it is necessary to understand fundamental issues in other branches of biomedicine.
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Table of Contents
1. Introduction2. Theories and definitions of tumors3. Etio-pathogenesis of tumors4. Growth of cells, growth factors and oncogenes5. Hereditary Predispositions to Tumors, Tumor Suppressor Genes, and their Clinico-Genomic Complexities6. The tumor types: the complexities in the combinations and variabilities of their traits7. Epidemiology of Tumors8. Aspects of the prevention of tumors9. Clinical features of tumors 10. Morphologic assessment of cases of tumors11. Endoscopic Visualisation and Imaging in Diagnosis and Assessments of cases of Tumors12. Principles of surgery for tumors13. Principles of non-surgical therapies14. Aspects of radiation therapy15. Specific aspects of cytotoxic and hormonal drug therapies16. Immunological therapies17. Gene Therapies not Related to Immunological Therapies18. Other Therapies19. Care after primary treatment20. Costs, ethics and Malpractice LitigationAppendix1. Principles of normal histology and related cell biology2. The normal genome3. Fixed Genomic Events and Possible Mechanisms of their Causation by Etiological Agents4. Genomic instabilities in Tumor Cells and the Immortality of Tumor Cell Populations5. Methods in Histologic and Molecular Assessments of Tumors6. Biomarkers in Epidemiology, Molecular Pathology and Oncology7. Sub-lethal injuries and deaths of cells and tissues8. Pretarget, Target and Recovery Defences of Cells Against Carcinogens and Cytotoxic Agents9. Developing New Therapies
