For four decades, physicians and other healthcare providers have trusted Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on the diagnosis and treatment of these complex disorders. The 9th Edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to keep you at the forefront of this vitally important field. Meticulously updated by Drs. John E. Bennett, Raphael Dolin, and Martin J. Blaser, this comprehensive, two-volume masterwork puts the latest information on challenging infectious diseases at your fingertips.
- Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource.
- Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis.
- Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases.
- Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases.
- Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci.
- PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America.
- Includes regular updates online for the life of the edition.
- Features more than 1,500 high-quality, full-color photographs-with hundreds new to this edition.
- Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.
- Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource.
- Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis.
- Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases.
- Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases.
- Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci.
- PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America.
- Includes regular updates online for the life of the edition.
- Features more than 1,500 high-quality, full-color photographs-with hundreds new to this edition.
- Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.
Table of Contents
I Basic Principles in the Diagnosis and Management of Infectious DiseasesA MICROBIAL PATHOGENESIS
1 A Molecular Perspective of Microbial Pathogenicity
2 The Human Microbiome of Local Body Sites and Their Unique Biology
3 Prebiotics, Probiotics, and Synbiotics
B HOST DEFENSE MECHANISMS
4 Innate (General or Nonspecific) Host Defense Mechanisms
5 Adaptive Immunity: Antibodies and Immunodeficiencies
6 Cell-Mediated Defense Against Infection
7 Mucosal Immunity
8 Granulocytic Phagocytes
9 Complement and Deficiencies
10 Human Genetics and Infection
11 Nutrition, Immunity, and Infection
12 Evaluation of the Patient With Suspected Immunodeficiency
C EPIDEMIOLOGY OF INFECTIOUS DISEASE
13 Applied Epidemiology for the Infectious Diseases Physician
14 Emerging and Reemerging Infectious Disease Threats
15 Bioterrorism: An Overview
D CLINICAL MICROBIOLOGY
16 The Clinician and the Microbiology Laboratory: Test Ordering, Specimen Collection, and Result Interpretation
E ANTIINFECTIVE THERAPY
17 Principles of Antiinfective Therapy
18 Molecular Mechanisms of Antibiotic Resistance in Bacteria
19 Pharmacokinetics and Pharmacodynamics of Antiinfective Agents
20 Penicillins and �-Lactamase Inhibitors
21 Cephalosporins
22 Ertapenem, Imipenem, Meropenem, Doripenem, and Aztreonam
23 Antibiotic Allergy
24 Fusidic Acid
25 Aminoglycosides
26 Tetracyclines, Glycylcyclines, and Chloramphenicol
27 Rifamycins
28 Metronidazole
29 Macrolides and Clindamycin
30 Glycopeptides (Vancomycin and Teicoplanin) and Lipoglycopeptides (Telavancin, Oritavancin, and Dalbavancin)
31 Daptomycin and Quinupristin-Dalfopristin
32 Polymyxins (Polymyxin B and Colistin)
33 Linezolid, Tedizolid, and Other Oxazolidinones
34 Sulfonamides and Trimethoprim; Trimethoprim-Sulfamethoxazole
35 Quinolones
36 Unique Antibacterial Agents
37 Urinary Tract Agents: Nitrofurantoin, Fosfomycin, and Methenamine
38 Topical Antibacterials
39 Antimycobacterial Agents
40A Antifungal Agents: Amphotericin B
40B Antifungal Drugs: Azoles
40C Antifungal Drugs: Echinocandins
40D Antifungal Drugs: Flucytosine
41 Antimalarial Drugs
42 Drugs for Protozoal Infections Other Than Malaria
43 Drugs for Helminths
44 Antiviral Agents: General Principles
45 Antiviral Drugs for Influenza and Other Respiratory Virus Infections
46 Antivirals Against Herpesviruses
47 Antiviral Drugs Against Hepatitis Viruses
48 Miscellaneous Antiviral Agents (Interferons, Tecovirimat, Imiquimod, Pocapavir, Pleconaril)
49 Immunomodulators
50 Hyperbaric Oxygen
51 Antimicrobial Stewardship
52 Designing and Interpreting Clinical Studies in Infectious Diseases
53 Outpatient Parenteral Antimicrobial Therapy
54 Tables of Antiinfective Agent Pharmacology
II Major Clinical Syndromes
A FEVER
55 Temperature Regulation and the Pathogenesis of Fever
56 Fever of Unknown Origin
57 The Acutely Ill Patient With Fever and Rash
B UPPER RESPIRATORY TRACT INFECTIONS
58 The Common Cold
59 Pharyngitis
60 Acute Laryngitis
61 Otitis Externa, Otitis Media, and Mastoiditis
62 Sinusitis
63 Epiglottitis
64 Infections of the Oral Cavity, Neck, and Head
C PLEUROPULMONARY AND BRONCHIAL INFECTIONS
65 Acute Bronchitis
66 Acute Exacerbations of Chronic Obstructive Pulmonary Disease
67 Acute Pneumonia
68 Pleural Effusion and Empyema
69 Bacterial Lung Abscess
70 Chronic Pneumonia
71 Cystic Fibrosis
D URINARY TRACT INFECTIONS
72 Urinary Tract Infections
E SEPSIS
73 Sepsis and Septic Shock
F INTRAABDOMINAL INFECTIONS
74 Peritonitis and Intraperitoneal Abscesses
75 Infections of the Liver and Biliary System (Liver Abscess, Cholangitis, Cholecystitis)
76 Pancreatic Infection
77 Splenic Abscess
78 Appendicitis
79 Diverticulitis and Neutropenic Enterocolitis
G CARDIOVASCULAR INFECTIONS
80 Endocarditis and Intravascular Infections
81 Prosthetic Valve Endocarditis
82 Infections of Nonvalvular Cardiovascular Devices
83 Prevention of Infective Endocarditis
84 Myocarditis and Pericarditis
85 Mediastinitis
H CENTRAL NERVOUS SYSTEM INFECTIONS
86 Approach to the Patient With Central Nervous System Infection
87 Acute Meningitis
88 Chronic Meningitis
89 Encephalitis
90 Brain Abscess
91 Subdural Empyema, Epidural Abscess, and Suppurative Intracranial Thrombophlebitis
92 Cerebrospinal Fluid Shunt and Drain Infections
I SKIN AND SOFT TISSUE INFECTIONS
93 Cellulitis, Necrotizing Fasciitis, and Subcutaneous Tissue Infections
94 Myositis and Myonecrosis
95 Lymphadenitis and Lymphangitis
J GASTROINTESTINAL INFECTIONS AND FOOD POISONING
96 Syndromes of Enteric Infection
97 Esophagitis
98 Diarrhea With Little or No Fever
99 Acute Dysentery Syndromes (Diarrhea With Fever)
100 Typhoid Fever, Paratyphoid Fever, and Typhoidal Fevers
101 Foodborne Disease
102 Tropical Sprue and Environmental Enteric Dysfunction
K BONE AND JOINT INFECTIONS
103 Infectious Arthritis of Native Joints
104 Osteomyelitis
105 Orthopedic Implant-Associated Infections
L DISEASES OF THE REPRODUCTIVE ORGANS AND SEXUALLY TRANSMITTED DISEASES
106 Genital Skin and Mucous Membrane Lesions
107 Urethritis
108 Vulvovaginitis and Cervicitis
109 Infections of the Female Pelvis
110 Prostatitis, Epididymitis, and Orchitis
M EYE INFECTIONS
111 Introduction to Eye Infections
112 Microbial Conjunctivitis
113 Microbial Keratitis
114 Endophthalmitis
115 Infectious Causes of Uveitis
116 Periocular Infections
N HEPATITIS
117 Viral Hepatitis
O ACQUIRED IMMUNODEFICIENCY SYNDROME
118 Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome
119 Epidemiology and Prevention of AIDS and HIV Infection, Including Preexposure Prophylaxis and HIV Vaccine Development
120 Diagnosis of Human Immunodeficiency Virus Infection
121 The Immunology of Human Immunodeficiency Virus Infection
122 General Clinical Manifestations of Human Immunodeficiency Virus Infection (Including Acute Retroviral Syndrome and Oral, Cutaneous, Renal, Ocular, Metabolic, and Cardiac Diseases)
123 Pulmonary Manifestations of Human Immunodeficiency Virus Infection
124 Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of Human Immunodeficiency Virus Infection
125 Neurologic Diseases Caused by Human Immunodeficiency Virus Type 1 and Opportunistic Infections
126 Human Immunodeficiency Virus Infection in Women
127 Pediatric Human Immunodeficiency Virus Infection
128 Antiretroviral Therapy for Human Immunodeficiency Virus Infection
129 Management of Opportunistic Infections Associated With Human Immunodeficiency Virus Infection
P MISCELLANEOUS SYNDROMES
130 Chronic Fatigue Syndrome (Systemic Exertion Intolerance Disease)
III Infectious Diseases and Their Etiologic Agents
A VIRAL DISEASES
131 Biology of Viruses and Viral Diseases
132 Orthopoxviruses Vaccinia (Smallpox Vaccine), Variola (Smallpox), Monkeypox, and Cowpox
133 Other Poxviruses That Infect Humans: Parapoxviruses (Including Orf Virus), Molluscum Contagiosum, and Yatapoxviruses
134 Introduction to Herpesviridae
135 Herpes Simplex Virus
136 Chickenpox and Herpes Zoster (Varicella-Zoster Virus)
137 Cytomegalovirus
138 Epstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus-Associated Malignant Diseases, and Other Diseases)
139 Human Herpesvirus Types 6 and 7 (Exanthem Subitum)
140 Kaposi Sarcoma-Associated Herpesvirus (Human Herpesvirus 8)
141 Herpes B Virus
142 Adenoviruses
143 Papillomaviruses
144 JC, BK, and Other Polyomaviruses: Progressive Multifocal Leukoencephalopathy (PML)
145 Hepatitis B Virus
146 Hepatitis Delta Virus
147 Human Parvoviruses, Including Parvovirus B19V and Human Bocaparvoviruses
148 Orthoreoviruses and Orbiviruses
149 Coltiviruses (Colorado Tick Fever Virus) and Seadornaviruses
150 Rotaviruses
151 Alphaviruses (Chikungunya, Eastern Equine Encephalitis)
152 Rubella Virus (German Measles)
153 Flaviviruses (Dengue, Yellow Fever, Japanese Encephalitis, West Nile Encephalitis, Usutu Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis, Kyasanur Forest Disease, Alkhurma Hemorrhagic Fever, Zika)
154 Hepatitis C
155 Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS)
156 Parainfluenza Viruses
157 Mumps Virus
158 Respiratory Syncytial Virus
159 Human Metapneumovirus
160 Measles Virus (Rubeola)
161 Zoonotic Paramyxoviruses: Nipah, Hendra, and Menangle Viruses
162 Vesicular Stomatitis Virus and Related Vesiculoviruses (Chandipura Virus)
163 Rabies (Rhabdoviruses)
164 Marburg and Ebola Virus Hemorrhagic Fevers
165 Influenza Viruses, Including Avian Influenza and Swine Influenza
166 California Encephalitis, Hantavirus Pulmonary Syndrome, Hantavirus Hemorrhagic Fever With Renal Syndrome, and Bunyavirus Hemorrhagic Fevers
167 Lymphocytic Choriomeningitis Virus, Lassa Virus, and the South American Hemorrhagic Fevers (Arenaviruses)
168 Human T-Cell Leukemia Viruses (HTLV-1, HTLV-2)
169 Human Immunodeficiency Viruses
170 Introduction to the Human Enteroviruses and Parechoviruses
171 Poliovirus
172 Coxsackieviruses, Echoviruses, and Numbered Enteroviruses (EV-A71, EVD-68, EVD-70)
173 Parechoviruses
174 Hepatitis A Virus
175 Rhinovirus
176 Noroviruses and Sapoviruses (Caliciviruses)
177 Astroviruses and Picobirnaviruses
178 Hepatitis E Virus
B PRION DISEASES
179 Prions and Prion Disease of the Central Nervous System (Transmissible Neurodegenerative Diseases)
C CHLAMYDIAL DISEASES
180 Chlamydia trachomatis (Trachoma and Urogenital Infections)
181 Psittacosis (Due to Chlamydia psittaci)
182 Chlamydia pneumoniae
D MYCOPLASMA DISEASES
183 Mycoplasma pneumoniae and Atypical Pneumonia
184 Genital Mycoplasmas: Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma Species
E RICKETTSIOSES, EHRLICHIOSES, AND ANAPLASMOSES
185 Introduction to Rickettsioses, Ehrlichioses, and Anaplasmoses
186 Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)
187 Rickettsia akari (Rickettsialpox)
188 Coxiella burnetii (Q Fever)
189 Rickettsia prowazekii (Epidemic or Louse-Borne Typhus)
190 Rickettsia typhi (Murine Typhus)
191 Orientia tsutsugamushi (Scrub Typhus)
192 Ehrlichia chaffeensis (Human Monocytotropic Ehrlichiosis), Anaplasma phagocytophilum (Human Granulocytotropic Anaplasmosis), and Other Anaplasmataceae
F BACTERIAL DISEASES
193 Introduction to Bacteria and Bacterial Diseases
194 Staphylococcus aureus (Including Staphylococcal Toxic Shock Syndrome)
195 Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci
196 Classification of Streptococci
197 Streptococcus pyogenes
198 Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis
199 Streptococcus pneumoniae
200 Enterococcus Species, Streptococcus gallolyticus Group, and Leuconostoc Species
201 Streptococcus agalactiae (Group B Streptococci)
202 Viridans Streptococci, Nutritionally Variant Streptococci, and Groups C and G Streptococci
203 Streptococcus anginosus Group
204 Corynebacterium diphtheriae (Diphtheria)
205 Other Coryneform Bacteria, Arcanobacterium haemolyticum, and Rhodococci
206 Listeria monocytogenes
207 Bacillus anthracis (Anthrax)
208 Bacillus Species and Related Genera Other Than Bacillus anthracis
209 Erysipelothrix Rhusiopathiae
210 Whipple Disease
211 Neisseria meningitidis
212 Neisseria gonorrhoeae (Gonorrhea)
213 Moraxella catarrhalis, Kingella, and Other Gram-Negative Cocci
214 Vibrio cholerae
215 Other Pathogenic Vibrios
216 Campylobacter jejuni and Related Species
217 Helicobacter pylori and Other Gastric Helicobacter Species
218 Enterobacteriaceae
219 Pseudomonas aeruginosa and Other Pseudomonas Species
220 Stenotrophomonas maltophilia and Burkholderia cepacia Complex
221 Burkholderia pseudomallei and Burkholderia mallei: Melioidosis and Glanders
222 Acinetobacter Species
223 Salmonella Species
224 Bacillary Dysentery: Shigella and Enteroinvasive Escherichia coli
225 Haemophilus Species, Including H. influenzae and H. ducreyi (Chancroid)
226 Brucellosis (Brucella Species)
227 Francisella tularensis (Tularemia)
228 Pasteurella Species
229A Plague (Yersinia pestis)
229B Yersinia enterocolitica and Yersinia pseudotuberculosis
230 Bordetella pertussis
231 Rat-Bite Fever: Streptobacillus moniliformis and Spirillum minus
232 Legionnaires' Disease and Pontiac Fever
233 Capnocytophaga
234 Bartonella, Including Cat-Scratch Disease
235 Klebsiella granulomatis (Donovanosis, Granuloma Inguinale)
236 Other Gram-Negative and Gram-Variable Bacilli
237 Syphilis (Treponema pallidum)
238 Endemic Treponematoses
239 Leptospira Species (Leptospirosis)
240 Relapsing Fever Caused by Borrelia Species
241 Lyme Disease (Lyme Borreliosis) Due to Borrelia burgdorferi
242 Anaerobic Infections: General Concepts
243 Clostridioides difficile (Formerly Clostridium difficile) Infection
244 Tetanus (Clostridium tetani)
245 Botulism (Clostridium botulinum)
246 Diseases Caused by Clostridium
247 Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species (and Other Medically Important Anaerobic Gram-Negative Bacilli)
248 Anaerobic Cocci and Anaerobic Gram-Positive Nonsporulating Bacilli
249 Mycobacterium tuberculosis
250 Leprosy (Mycobacterium leprae)
251 Mycobacterium avium Complex
252 Infections Caused by Nontuberculous Mycobacteria Other Than Mycobacterium avium Complex
253 Nocardia Species
254 Agents of Actinomycosis
G MYCOSES
255 Introduction to Mycoses
256 Candida Species
257 Aspergillus Species
258 Agents of Mucormycosis and Entomophthoramycosis
259 Sporothrix schenckii
260 Agents of Chromoblastomycosis
261 Agents of Mycetoma
262 Cryptococcosis (Cryptococcus neoformans and Cryptococcus gattii)
263 Histoplasma capsulatum (Histoplasmosis)
264 Blastomycosis
265 Coccidioidomycosis (Coccidioides Species)
266 Dermatophytosis (Ringworm) and Other Superficial Mycoses
267 Paracoccidioidomycosis
268 Uncommon Fungi and Related Species
269 Pneumocystis Species
270 Microsporidiosis
H PROTOZOAL DISEASES
271 Introduction to Protozoal Diseases
272 Entamoeba Species, Including Amebic Colitis and Liver Abscess
273 Free-Living Amebae
274 Malaria (Plasmodium Species)
275 Leishmania Species: Visceral (Kala-Azar), Cutaneous, and Mucosal Leishmaniasis
276 Trypanosoma Species (American Trypanosomiasis, Chagas Disease): Biology of Trypanosomes
277 Agents of African Trypanosomiasis (Sleeping Sickness)
278 Toxoplasma gondii
279 Giardia lamblia
280 Trichomonas vaginalis
281 Babesia Species
282 Cryptosporidiosis (Cryptosporidium Species)
283 Cyclospora cayetanensis, Cystoisospora belli, Sarcocystis Species, Balantidium coli, and Blastocystis Species
I DISEASES DUE TO TOXIC ALGAE
284 Human Illness Associated With Harmful Algal Blooms
J DISEASES DUE TO HELMINTHS
285 Introduction to Helminth Infections
286 Intestinal Nematodes (Roundworms)
287 Tissue Nematodes, Including Trichinellosis, Dracunculiasis, Filariasis, Loiasis, and Onchocerciasis
288 Trematodes (Schistosomes and Liver, Intestinal, and Lung Flukes)
289 Tapeworms (Cestodes)
290 Visceral Larva Migrans and Other Uncommon Helminth Infections
K ECTOPARASITIC DISEASES
291 Introduction to Ectoparasitic Diseases
292 Lice (Pediculosis)
293 Scabies
294 Myiasis and Tungiasis
295 Mites, Including Chiggers
296 Ticks, Including Tick Paralysis
L DISEASES OF UNKNOWN ETIOLOGY
297 Kawasaki Disease
IV Special Problems
A NOSOCOMIAL INFECTIONS
298 Infection Prevention and Control in the Health Care Setting
299 Disinfection, Sterilization, and Control of Hospital Waste
300 Infections Caused by Percutaneous Intravascular Devices
301 Nosocomial Pneumonia
302 Health Care-Associated Urinary Tract Infections
303 Health Care-Acquired Hepatitis
304 Transfusion- and Transplantation-Transmitted Infections
B INFECTIONS IN SPECIAL HOSTS
305 Infections in the Immunocompromised Host: General Principles
306 Prophylaxis and Empirical Therapy of Infection in Cancer Patients
307 Infections in Recipients of Hematopoietic Stem Cell Transplants
308 Infections in Solid-Organ Transplant Recipients
309 Infections in Patients With Spinal Cord Injury
310 nfections in Older Adults
311 Infections in Asplenic Patients
312 Infections in Injection Drug Users
313 Surgical Site Infections and Antimicrobial Prophylaxis
C SURGICAL- AND TRAUMA-RELATED INFECTIONS
314 Burns
315 Bites
D IMMUNIZATION
316 Immunization
E ZOONOSES
317 Zoonoses
F PROTECTION OF TRAVELERS
318 Protection of Travelers
319 Infections in Returning Travelers
