Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Volume 168 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, Propagation and removal of cerebral amyloid angiopathy, and much more.
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Table of Contents
Section I: TARGETTING AD1. Fluid biomarker-based molecular phenotyping of Alzheimer's disease patients in research and clinical settings
Kaj Blennow and Henrik Zetterberg
2. Tracking down a missing trigger for Alzheimer's disease by mass spectrometric imaging based on brain network analysis
Minako Hoshi
3. Using mirror-image peptides to enhance robustness and reproducibility in studying the amyloid ?-protein
Ariel J. Kuhn and Jevgenij A. Raskatov
Section II: ETIOLOGY OF AD
4. In search of pathogenic amyloid ?-peptide in familial Alzheimer's disease
Michael S. Wolfe
5. Biology of splicing in Alzheimer's disease research
Kenichi Nagata, Takashi Saito, Takaomi C. Saido and Takashi Morihara
6. Acquired cerebral amyloid angiopathy: An emerging concept
Masahito Yamada, Tsuyoshi Hamaguchi and Kenji Sakai
Section III: NEUROIMMUNOLOGY OF AD
7. Blood-brain barrier and innate immunity in the pathogenesis of Alzheimer's disease
Goran Simic, Ena Spanic, Lea Langer Horvat and Patrick R. Hof
8. Gut microbiota mediated allostasis prevents stress-induced neuroinflammatory risk factors of Alzheimer's disease
Susan Westfall, Umar Iqbal, Maria Sebastian and Giulio Maria Pasinetti
9. Neuroimmune interactions in Alzheimer's disease-New frontier with old challenges?
Stefan Prokop, Virginia M.Y. Lee and John Q. Trojanowski
Section IV: AD THERAPY
10. Alzheimer's therapy development: A few points to consider
Einar M. Sigurdsson
11. The next steps in curing Alzheimer's disease
Fred W. van Leeuwen
12. Future horizons in Alzheimer's disease research
Thomas Wisniewski and Eleanor Drummond
13. Why delay in effective treatment for Alzheimer's disease and related conditions
Khalid Iqbal, Fei Liu, ChengXin Gong, Chunling Dai and Wen Hu
14. Restoring synaptic function through multimodal therapeutics
Raul Loera-Valencia, Muhammad-Al-Mustafa Ismail, Per Nilsson and Bengt Winblad
15. Disease-modifying therapy for proteinopathies: Can the exception become the rule?
Gal Bitan
16. Combination therapy for Alzheimer's disease and related dementias
Martin M. Bednar
Section V: ALPHA-SYNUCLEINOPATHIES
17. Can infections trigger alpha-synucleinopathies?
Christopher T. Tulisiak, Gabriela Mercado, Wouter Peelaerts, Lena Brundin and Patrik Brundin
18. Prion-like propagation of a-synuclein in neurodegenerative diseases
Airi Tarutani and Masato Hasegawa
Section VI: MODEL SYSTEMS
19. Yeast models of neurodegenerative diseases
Mick F. Tuite
