Clinical Molecular Medicine: Principles and Practice presents the latest scientific advances in molecular and cellular biology, including the development of new and effective drug and biological therapies and diagnostic methods. The book provides medical and biomedical students and researchers with a clear and clinically relevant understanding on the molecular basis of human disease. With an increased focus on new practice concepts, such as stratified, personalized and precision medicine, this book is a valuable and much-needed resource that unites the core principles of molecular biology with the latest and most promising genomic advances.
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Table of Contents
Part I. FUNDAMENTALS OF MOLECULAR MEDICINE 1. The human genome and molecular medicine 2. Cellular structure and molecular cell biology 3. Molecular basis of clinical metabolomics 4. Clinical applications of next-generation sequencing
Part II. MOLECULAR MEDICINE IN CLINICAL PRACTICE 5. Molecular basis of obesity disorders 6. Molecular dysmorphology 7. Disorders of sex development 8. Molecular systems in cardiovascular developmental disorders 9. Channelopathies in clinical medicine-cardiac arrhythmias 10. Chronic heart failure 11. Molecular pathophysiology of systemic hypertension 12. Molecular basis of stroke 13. Clinical molecular endocrinology 14. Genetic disorders of lipoprotein metabolism 15. Molecular medicine of diabetes mellitus 16. Molecular genetic management of epilepsy 17. The human leukocyte antigen system in human disease and transplantation medicine 18. Disorders of abnormal hemoglobin 19. Coagulation and bleeding disorders 20. Molecular and genomic basis of bronchial asthma 21. Molecular systems in inflammatory bowel disease 22. Molecular biology of acute and chronic inflammation 23. Molecular basis of susceptibility and protection from microbial infections 24. Molecular mechanisms in cancer susceptibility-lessons from inherited cancers 25. Clinical molecular nephrology-acute kidney injury and chronic kidney disease 26. Molecular basis of chronic neurodegeneration 27. Molecular basis of movement disorders 28. Molecular pathology in neuropsychiatric disorders 29. Targeted molecular therapy: the cancer paradigm 30. Gene, genome, and molecular therapeutics 31. Personalizing medicine with pharmacogenetics and pharmacogenomics 32. Integrated genomic and molecular medicine
Authors
Dhavendra Kumar Honorary Clinical Professor, William Harvey Research Institute, Queen Mary University of London, UK. Professor Kumar has considerable previous experience in writing and editing books and journals related to genetics and genomics. His books include Genomics and Clinical Medicine and Genomics and Health in the Developing World. He founded and leads the new open access journal Applied and Translational Genomics, published by Elsevier. He has published 40 articles in the journals literature.Professor Dhavendra Kumar is a Visiting Professor, Genomic Policy Unit, Faculty of Life Sciences and Education, The University of South Wales and Consultant in Clinical Genetics at the University Hospital of Wales, Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom. He is one of the Consultants for the All Wales Medical Genetics Service and the lead Clinician for Clinical Cardiovascular Genetics. After qualifying in Medicine from the King George's Medical College, University of Lucknow, India, he completed postgraduate training in Pediatrics with an MD. Since 1980 he has pursued a career in Medical Genetics in the UK. In 1990 he became a Diplomate of the American Board of Medical Genetics. He is a Fellow of the American College of Medical Genetics (FACMG) and as well as Royal Colleges of Physicians (FRCP-London and FRCP-Ireland) and Pediatrics and Child Health (FRCPCH-UK).
In 2015, he was conferred with the higher degree of DSc by his Alma Mater, King George's Medical University, Lucknow (UP, India) based on his life-time contributions and achievements to genetic and genomic applications in medicine and health.
