This monograph focuses on the actions exerted by sex hormones, 17ß-estradiol, and testosterone, in skeletal muscle tissue. An important consideration of this volume is the fact that both estrogen receptors (ERs) and androgen receptors (ARs) are ubiquitously expressed and, as a result, steroid hormones affect growth and different cell functions in several organs. Moreover, ERs and ARs may have a non-classical pattern of intracellular localization, raising complexity to the functional roles of estradiol and testosterone.
Readers will find key information about the role of sex hormones in mitochondrial physiology and their relation with aging, apoptosis, and sarcopenia. Chapters integrate important points with the latest information on the subject, including work of leading researchers studying the cellular and molecular mechanisms underlying the age-linked changes in muscle tissue while highlighting the role of satellite cells.
Furthermore, the book presents a chapter about phytoestrogens (compounds which are structurally very similar to estrogen 17ß-estradiol) and their selective action on sex steroid receptors (specifically, they have a higher affinity for ERß receptors than ERa receptors).
The book is recommended reading for scientists and clinicians involved in the field of medical and health sciences as well as for scholarly readers (students of biochemistry and medicine) who are interested in the molecular mechanism of cellular apoptosis regulated by steroid hormones
Table of Contents
Chapter 1 Subcellular Localization and Physiological Roles of Androgen Receptor
Chapter 2 Subcellular Localization of Estrogen Receptors
Chapter 3 Estrogens and Androgens Binding Sites in Mitochondria
Chapter 4 General Concepts of Skeletal Muscle and Apoptosis: Molecular Mechanisms and Regulation by Sex Steroids
Chapter 5 Antiapoptotic Effects Of Estrogens And Androgens
Chapter 6 Role of Sex Hormones in Cytoskeletal Structure: Implications in Cellular Lifespan
Chapter 7 Apoptosis as Cause of Sarcopenia: Hormonal Regulation
Chapter 8 The Role of Phytoestrogens in Apoptosis: Chemical Structures and Actions on Specific Receptors
Chapter 9 Conclusions
Subject Index
Author
- Andrea A. Vasconsuelo