100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world's leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics.
100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification.
100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule.
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Table of Contents
Forward- 100 Years of hCG Introduction 100 Years of hCG Meet the Editors and the Authors Section 1 Genes and Structure Chapter 1.1 Isolating C5 and B152 Anecdote Chapter 1.2 Evolutionary, structural and physiological differences between hCG and LH Chapter 1.3 hCG and Human Evolution The Master Molecule Chapter 1.4 Human Chorionic Gonadotropin: Different Origins, Glycoforms and Functions during Pregnancy Chapter 1.5 Molecular Modelling of hCG: influence of glycosylation and nicking on molecular folding and epitope recognition Chapter 1.6 Why is hCG Glycosylated Section 2 Detection and Quantitation Chapter 2.1 Detecting hCG that's not there Annecdote Chapter 2.2 Quantification of hCG by MALDI ToF Mass Spectrometry Chapter 2.3 Pregnancy failures and false positive hCG tests Chapter 2.4 Home Pregnancy Tests Chapter 2.5 Human Chorionic Gonadotropin determination using mass spectrometry Chapter 2.6 Beta core fragment as a standard quality control in MALDI Section 3 Pregnancy and Fertility Chapter 3.1 hCG as an LH analogue Anecdote Chapter 3.2 The role of hCG in endometrial receptivity and embryo implantation Chapter 3.3 Qualitative Analysis of hCG Variants and Glycoforms in Urine Chapter 3.4 Phenotypic characterization of a transgenic mouse model overproducing hCG Chapter 3.5 The Role of Human Chorionic Gonadotropin in Reproductive Medicine Chapter 3.6 Pregnancy and hCG Chapter 3.7 My Journey with Human Chorionic Gonadotropin: development of a Unique Vaccine for control of fertility Chapter 3.8 Evaluation of Delivery Vectors for Active Immunisation with Synthetic Peptides of hCG as a Fertility Control Method Section 4 Cancer and Therapy Chapter 4.1 How hCG and a failed experiment changed my life Anecdote Chapter 4.2 Human chorionic gonadotropin in cancer where are we? Chapter 4.3 LH/hCG-receptor independent activities of hCG and hCG� Chapter 4.4 The Role of the Free Beta Subunit of Human Chorionic Gonadotropin in Human Malignancy Chapter 4.5 hCG and Gestational Trophoblastic Diseases Hydatidiform Mole and Choriocarcinoma Chapter 4.6 Immunotherapy of Advanced Stage, Invariably Drug Resistant Cancer Expressing ectopically hCG Chapter 4.7 A Potential Cure for Cancer Section 5 Conclusion Chapter 5.1 Where has hCG research been? What is hCG research doing? Which direction will it go in the future?
