Toxoplasma gondii: The Model Apicomplexan - Perspectives and Methods, Third Edition, reflects significant advances in the field in the last five years, including new information on the genomics, epigenomics and proteomics of T. gondii, along with a new understanding of the population biology and genetic diversity of this organism. This edition expands information on the effects of T. gondii on human psychiatric disease and new molecular techniques, such as CAS9/CSPR. T gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.
Table of Contents
1. The History and Life Cycle of Toxoplasma gondii2. The Ultrastructure of Toxoplasma gondii
3. Molecular Epidemiology and Population Structure of Toxoplasma gondii
4. Human Toxoplasma Infection
5. Ocular Disease due to Toxoplasma gondii
6. Toxoplasmosis in Wild and Domestic Animals
7. Toxoplasma Animal Models and Therapeutics
8. Biochemistry and Metabolism of Toxoplasma gondii: Lipids and Nutrient Acquisition
9. Biochemistry and Metabolism of Toxoplasma gondii: Nucleotide and Amino Acid Metabolism
10. Biochemistry and Metabolism of Toxoplasma gondii: Carbohydrates and Metabolomics
11. The Apicoplast and Mitochondrion of Toxoplasma gondii
12. Calcium Storage and Homeostasis in Toxoplasma gondii
13. Signaling Networks in Toxoplasma gondii
14. Toxoplasma Secretory Proteins (Micronemes, Rhoptries, Dense Granules)
15. Toxoplasma Secretory Pathway, Intracellular Trafficking, and Autophagy
16. The Toxoplasma Cytoskeleton: Structures, Proteins and Processes (Need to include actin)
17. Toxoplasma Host Effectors in Cell Interactions
18. Bradyzoite and Sexual Stage Development
19. Development and Application of Classical Genetics in Toxoplasma gondii
20. Genetic Manipulation of Toxoplasma gondii
21. Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii
22. Proteomics and Post Translational Protein Modifications in Toxoplasma gondii
23. ToxoDB: An Integrated Functional Genomic Resource for Toxoplasma and Other Sarcocystidae
24. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioral Consequences
25. Innate Immunity to Toxoplasma gondii
26. Adaptive Immunity and Genetics of the Host Immune Response