Through eight outstanding editions, Middleton's Allergy: Principles and Practice has been the reference of choice for both clinicians and researchers as both a practical reference and an effective self-assessment tool for board preparation. The 9th Edition continues the tradition of excellence with comprehensive coverage of all basic science and clinical applications regarding allergy practice and disease mechanisms. It brings you fully up to date with recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies.
- Offers unparalleled depth and up-to-date guidance on the full spectrum of allergy across the lifespan, with significant updates throughout.
- Contains new chapters on Innate Lymphoid Cells, Systems Biology, and Treatment of Primary Immunodeficiency Diseases.
- Discusses emerging topics such as epidemic thunderstorm asthma and precision medicine in allergic disorders.
- Features more than 730 full-color illustrations, including many new cellular and molecular drawings of disease mechanisms.
- Includes new Summary of Important Concepts boxes, plus new multiple-choice questions online with explanations and answers.
- Features a new team of expert editors and more international contributors for a global perspective of this complex field.
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Table of Contents
Volume 1SECTION A Basic Sciences Underlying Allergy and Immunology
1 Innate Immunity
2 Adaptive Immunity
3 Immunoglobulin Structure and Function
4 Immune Tolerance
5 Cytokines in Allergic Inflammation
6 Cellular Adhesion in Inflammation
7 Chemokines
8 The Complement System
9 Lipid Mediators of Hypersensitivity and Inflammation
10 Molecular Biology and Genetic Engineering
11 Biology of Lymphocytes
12 Innate Lymphoid Cells
13 Antigen-Presenting Dendritic Cells
14 Biology of Mast Cells and Their Mediators
15 Biology of Basophils
16 Biology of Eosinophils
17 Biology of Neutrophils
18 Biology of Monocytes and Macrophages
19 Airway Epithelial Cells
20 Airway Smooth Muscle
21 Pathophysiology of Allergic Inflammation
22 Genetics and Epigenetics in Allergic Diseases and Asthma
CONTENTS
23 Systems Biology
24 Immunobiology of IgE and Its Receptors
25 Neuronal Control of Airway Function in Allergy
SECTION B Aerobiology and Allergens
26 The Structure and Function of Allergens
27 Aerobiology of Outdoor Allergens
28 Indoor Allergens
29 Preparation and Standardization of Allergen Extracts
30 Air Pollution: Indoor and Outdoor
31 Effect of the Food Matrix and Processing on the Allergenic Activity of Foods
SECTION C The Skin
32 Structure of the Skin and Cutaneous Immunology
33 Atopic Dermatitis
34 Contact Dermatitis
35 Urticaria and Angioedema
36 Hereditary Angioedema and Bradykinin-Mediated Angioedema
37 Immune Complex Mediated Diseases
SECTION D The Eye
38 Allergic and Immunologic Diseases of the Eye
SECTION E Respiratory Tract
39 The Nose and Control of Nasal Airflow
40 Allergic and Nonallergic Rhinitis
41 Rhinosinusitis and Nasal Polyps
42 Development, Structure Lung and in Asthma
43 Respiratory Tract Mucosal Immunology
44 Airway Mucus and the Mucociliary System
45 Epidemiology of Asthma and Allergic Diseases
46 Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma
47 Asthma Pathogenesis
48 Animal Models of Allergic Disease
49 Diagnosis of Asthma in Infants and Children
50 Management of Asthma in Infants and Children
51 Diagnosis of Asthma in Adults
52 Management of Asthma in Adolescents and Adults
53 Emergency Treatment and Approach to the Patient with Acute Asthma
54 Approach to the Patient with Exercise-Induced Bronchoconstriction
55 Asthma and Allergic Diseases during Pregnancy
56 Occupational Allergy and Asthma
57 Pathology of Asthma
58 Allergic Bronchopulmonary Aspergillosis Hypersensitivity Pneumonitis and Epidemic Thunderstorm Asthma
59 Immunologic Nonasthmatic Diseases of the Lung
60 Approach to the Patient with Chronic Cough
61 Bronchial and Nasal Challenge Testing
62 Lung Imaging
63 Aerosols and Aerosol Drug Delivery Systems
VOLUME 2
SECTION F Gastrointestinal Tract
64 Gastrointestinal Mucosal Immunology
65 Eosinophilic Gastroenteropathies Disorders
SECTION G Systemic Disease
66 Clinical Significance of Immunoglobulin E
67 In Vivo Methods for the Study and Diagnosis of Allergy
68 Approach to the Patient with Recurrent Infections
69 Primary Immunodeficiency Diseases
70 Treatment of Primary Immunodeficiencies
71 Human Immunodeficiency Virus and Allergic Disease
72 Laboratory Tests for Allergic and Immunodeficiency Diseases
73 Eosinophilia and Eosinophil-Related Disorders
74 Mastocytosis
75 Anaphylaxis
76 Insect Allergy
77 Drug Allergy
78 Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs
79 Reactions to Foods
80 Reactions to Additives in Foods in Drugs
81 Oral Food Challenge Testing
82 Food Allergy Management
83 Adverse Reactions to Vaccines
SECTION H Therapeutics
84 Allergen Control for Prevention and Management of Allergic Diseases
85 Injection Immunotherapy for Inhalant Allergens
86 Sublingual Immunotherapy for Inhalant Allergens
87 Principles of Pharmacotherapeutics
88 Precision Medicine in Allergic Disorders
89 Adherence
90 Anti-Immunoglobulin E Therapy
91 Cytokine-Specific Therapy in Asthma
92 Histamine and Antihistamines
93 Inhaled �2-Agonists
94 Theophylline and Phosphodiesterase Inhibitors
95 Anticholinergic Therapies
96 Glucocorticosteroids
97 Antileukotriene Therapy in Asthma
98 Unconventional Theories and Unproven Methods in Allergy
99 Complementary and Alternative Medicine
