Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression.
This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research.
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Table of Contents
1. Preanalytics2. Study design3. Analytics4. Biostatistics5. Bioinformatics6. Biomarkers7. Animal models and other approaches8. Personalised medicine approaches
Authors
Jerzy Adamski Professor of Biology, Technische Universit�t M�nchen, Germany, Direktor, Helmholtz Zentrum M�nchen, Molecular Endocrinology and Metabolism, and Genome Analysis Center, Germany. Dr. Jerzy Adamski's interest is to identify the factors responsible for the pathogenesis of cancer and complex metabolic diseases like diabetes and environmentally challenged diseases like asthma. He contributed to discovery of molecular basis of a sub-type of Zellweger syndrome (bifunctional protein deficiency). Dr. Adamski analyzed mechanisms of steroid hormone pre-receptor control on DNA, protein and metabolite level. His laboratory discovered human 17beta-HSD types 4, 7 and 14 and analyzed their promotors, subcellular localization, metabolic profile and associations with disease. He developed molecular tools like monoclonal antibodies or mass-spectrometry based assays. Recently, Dr. Adamski published the first genome wide analysis with metabolomics. By that he discovered impact of SNPs on genetically determined metabotypes in normal and disease-overt humans. He studies genetic predisposition to environmental challenges like nicotine, coffee, and gender-specific predispositions to disease. Finally, Dr. Adamski is committed to training of pre- and post-doctoral fellows of Technical University of Munich, with students coming from divisions of biology, biotechnology and biochemistry. He organized several international workshops and meetings fostering interdisciplinary scientific exchange of state-of-the-art and networking.Dr. Adamski is currently Editor-in-Chief of The Journal of Steroid Biochemistry and Molecular Biology and was awarded with Paula und Richard von Hertwig Prize for Interdisciplinary Research in 2010.
