This completely updated and expanded 2nd edition of Systemic Lupus Erythematosus, A Manual includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter is short and is presented critically with selected references, which should be valuable to a wider audience. This book combines basic with clinical science to help internists and specialists in the diagnosis and management of patients with SLE. It is a quick referral for people in the pharmaceutical industry in their efforts to bring much-needed drugs. It provides all the needed information to basic researchers old and new alike, who wish to enter the field of lupus and systemic autoimmunity in general.
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Table of Contents
Part I Epidemiology and diagnosis1. History of systemic lupus erythematosus with an emphasis on certain recent major issues
Shu Man Fu and Felicia Gaskin
2. The patient
Donald E. Thomas, Jr.
3. A plea of a young patient to the lupus experts
Brianna Fitzpatrick
4. Epidemiology
Manuel F. Ugarte-Gil, Guillermo J. Pons-Estel and Graciela S. Alarc�n
5. Measuring disease activity
Joan T. Merrill
6. Disease development and outcome
Mary Mahieu, Dafna Gladman and Rosalind Ramsey-Goldman
7. Socioeconomic aspects of SLE
Titilola Falasinnu and Julia F. Simard
8. Biomarkers in systemic lupus erythematosus
Stacy P. Ardoin and Wael N. Jarjour
Part II Pathogenesis
9. Overview of the pathogenesis of systemic lupus erythematosus
Antonio La Cava
10. System lupus erythematosus and the environment
Soad Haj Yahia and Nancy Agmon-Levin
11. Genes and genetics in human SLE
Mara L. Lennard Richard and Betty P. Tsao
12. Monogenic lupus
Mindy S. Lo
13. Hormones
Takayuki Katsuyama and Vaishali R. Moulton
14. Clinical aspects of the complement system in systemic lupus erythematosus
John P. Atkinson, M. Kathryn Liszewski and C. Yung Yu
15. T cells
Florencia Rosetti and Jos� C. Crisp�n
16. B cells in SLE
Andreia C. Lino and Thomas D�rner
17. Neutrophils in systemic lupus erythematosus
Amr H. Sawalha
18. The role of dendritic cells in systemic lupus erythematosus
Manon Charrier, Christophe Richez, Estibaliz Lazaro, Vanja Sisirak and Patrick Blanco
19. Cytokines
Takayuki Katsuyama and Vaishali R. Moulton
20. RNA/DNA sensing in SLE-Toll-like receptors and beyond
Caroline A. Jefferies and Amir Sharabi
21. The role of interferons in systemic lupus erythematosus
Ruth Fernandez-Ruiz and Timothy Niewold
22. Fc? receptors in autoimmunity and endorgan damage
T. Ernandez, K. Okubo, G. Saggu and T.N. Mayadas
23. Apoptosis, autophagy, and necrosis
Roberto Caricchio
24. Infections in early systemic lupus erythematosus pathogenesis
Rebecka Bourn, Samantha Slight-Webb and Judith A. James
25. Microbiota influences on systemic lupus erythematosus and Sj�gren's syndrome
Teri M. Greiling, Silvio Manfredo Vieira and Martin A. Kriegel
26. Origin of autoantibodies
Westley H. Reeves, Shuhong Han and Haoyang Zhuang
27. Anti-DNA antibodies
Susan Malkiel, Yemil Atisha-Fregoso and Betty Diamond
28. Antihistone and antispliceosome antibodies
Minoru Satoh, Marvin J. Fritzler and Edward K.L. Chan
29. Immune complexes in systemic lupus erythematosus
Keiju Hiromura and Masaomi Nangaku
30. MicroRNA in systemic lupus erythematosus
Bo Qu, Xiaoyue Jiang and Nan Shen
31. Metabolic control of lupus pathogenesis: central role for activation of the mechanistic target of rapamycin
Andras Perl
32. Epigenetics
Christian M. Hedrich
33. What do mouse models teach us about human SLE?
Ziaur S.M. Raman and Chandra Mohan
34. Genes and genetics of murine systemic lupus erythematosus
Dwight H. Kono and Argyrios N. Theofilopoulos
Part III Mechanisms of tissue damage
35. Mechanisms of renal damage in systemic lupus erythematosus
Shu Man Fu, Sun-Sang J. Sung, Hongyang Wang, Zhenhuan Zhao and Felicia Gaskin
36. Mechanisms of vascular damage in systemic lupus erythematosus
Sarfaraz A. Hasni and Mariana J. Kaplan
37. The mechanism of skin damage
Xin Huang, Haijing Wu, Christopher Chang and Qianjin Lu
38. Pathogenesis of tissue injury in the brain in patients with systemic lupus erythematosus
David Hunt
Part IV Clinical aspects of the disease
39. Constitutional symptoms and fatigue in systemic lupus erythematosus
Syahrul Sazliyana Shaharir and Caroline Gordon
40. The musculoskeletal system in SLE
Maria-Louise Barilla-LaBarca, Diane Horowitz, Galina Marder and Richard Furie
41. Cutaneous lupus erythematosus
Annegret Kuhn, Aysche Landmann and Gisela Bonsmann
42. The clinical evaluation of kidney disease in systemic lupus erythematosus
Brad H. Rovin, Isabelle Ayoub and Swati Arora
43. The pathology of lupus nephritis
Isaac Ely Stillman
44. Cardiovascular disease in systemic lupus erythematosus: an update
Stephanie Saeli, Tanmayee Bichile, Payal Thakkar and Susan Manzi
45. The lung in systemic lupus erythematosus
Lindsy Forbess, Daniel J. Wallace and Caroline Jefferies
46. Gastrointestinal, hepatic, and pancreatic disorders in systemic lupus erythematosus
Chi Chiu Mok
47. Systemic lupus erythematosus and infections
Amy Devlin and Robert H. Shmerling
48. Malignancies in systemic lupus erythematosus
Alexandra Ladouceur, Hiromi Tissera, Ann E. Clarke, Rosalind Ramsey-Goldman, Caroline Gordon, James E. Hansen and Sasha Bernatsky
49. The nervous system in systemic lupus erythematosus
David Hunt
50. Overlap syndromes
Eric L. Greidinger
51. Systemic lupus erythematosus and the eye
Erika M. Damato, Philip I. Murray and Alastair K.O. Denniston
52. Fertility and pregnancy in systemic lupus erythematosus
Bonnie L. Bermas and Lisa R. Sammaritano
53. Neonatal lupus
Clinical spectrum, biomarkers, pathogenesis, and approach to treatment
Jill P. Buyon, Amit Saxena, Peter M. Izmirly, Bettina Cuneo and Benjamin Wainwright
54. Incomplete lupus syndromes
Nancy J. Olsen
55. Lupus in children
Mindy S. Lo
56. Drug-induced lupus
Robert L. Rubin
57. Vasculitis in lupus
Anisur Rahman
Part V Antiphospholipid Syndrome
58. Pathogenesis of antiphospholipid syndrome
Olga Amengual and Tatsuya Atsumi
59. Antibodies and diagnostic tests in antiphosholipid syndrome
Cecilia Beatrice Chighizola, Maria Orietta Borghi and Pier Luigi Meroni
60. Clinical manifestations
Miyuki Bohgaki and Takao Koike
61. Nonsteroidal antiinflammatory drugs in systemic lupus erythematosus
Robert G. Lahita and Trina Pal
62. Value of antimalarial drugs in the treatment of lupus
Fadi Hassan, Mohammad E. Naffaa and Ziv Paz
63. Systemic glucocorticoids
Zahi Touma and Murray B. Urowitz
64. Cytotoxic drug treatment
Eleni A. Frangou, George Bertsias and Dimitrios T. Boumpas
65. Treatment of antiphospholipid syndrome
Savino Sciascia and Munther Khamashta
66. New treatments of systemic lupus erythematosus
Vasileios C Kyttaris
67. Repositioning drugs for systemic lupus erythematosus
Kathryn M. Kingsmore, Peter E. Lipsky and Amrie C. Grammer
Authors
George C. Tsokos Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center.George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.
