Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more.
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Table of Contents
- Vitamin A and its natural derivativesChris P.F. Redfern
- Post-natal all-trans-retinoic acid biosynthesis
Joseph L. Napoli
- Retinoid metabolism and functions mediated by retinoid binding-proteins
Joseph L. Napoli and Hong Sik Yoo
- Generation and isolation of recombinant retinoid oxidoreductase complex
Mark K. Adams, Olga V. Belyaeva and Natalia Y. Kedishvili
- Sample preparation for structural and functional analyses of the STRA6 receptor for retinol-binding protein
Brianna K. Costabile, Youn-Kyung Kim, Yunting Chen, Oliver B. Clarke, Loredana Quadro and Filippo Mancia
- Use of fixatives for immunohistochemistry and their application for detection of retinoic acid synthesizing enzymes in the central nervous system
Azita Kouchmeshky and Peter McCaffery
- Classical pathways of gene regulation by retinoids
Ehmke Pohl and Charles W.E. Tomlinson
- Protein-protein interactions in the regulation of RAR-RXR heterodimers transcriptional activity
Albane le Maire, Pierre Germain and William Bourguet
- Natural ligands of RXR receptors
Patricia Garc?a, Paula Lorenzo and Angel R. de Lera
- DNA recognition by retinoic acid nuclear receptors
Carole Peluso-Iltis, Judit Osz and Natacha Rochel
- Noncanonical retinoic acid signaling
Jennifer Nhieu, Yu-Lung Lin and Li-Na Wei
- Retinoic acid and microRNA
Lijun Wang, Atharva Piyush Rohatgi and Yu-Jui Yvonne Wan
- Analysis of vitamin A and retinoids in biological matrices
Lindsay C. Czuba, Guo Zhong, King Yabut and Nina Isoherranen
- Effects of vitamin A and retinoic acid on mouse embryonic stem cells and their differentiating progeny
Mary Ann Asson-Batres and Christopher W. Norwood
- Identifying vitamin A signaling by visualizing gene and protein activity, and by biochemical isolation of vitamin A metabolites
Stephen R. Shannon, Jianshi Yu, Amy E. Defnet, Danika Bongfeldt, Alexander R. Moise, Maureen A. Kane and Paul A. Trainor
- Whole mount in situ hybridization and immunohistochemistry for studying retinoic acid signaling in developing amphioxus
Matteo Bozzo, Simona Candiani and Michael Schubert
- Design of synthetic retinoids
David R. Chisholm and Andrew Whiting
- Application of human organotypic skin raft cultures for analysis of retinoid metabolism, retinoic acid signaling, and screening of bioactive rexinoids
Alla V. Klyuyeva, Kelli R. Goggans, Natalia Y. Kedishvili and Olga V. Belyaeva
- Tissue localization of retinoic acid receptor (RAR) active drugs
Azita Kouchmeshky, Timothy Goodman, Andy Whiting and Peter McCaffery
- The development of methodologies for high-throughput retinoic acid binding assays in drug discovery and beyond
Charles W.E. Tomlinson and Andrew Whiting
- Using the human CYP26A1 gene promoter as a suitable tool for the determination of RAR-mediated retinoid activity
Reza Zolfaghari, Floyd J. Mattie, Cheng-Hsin Wei, David R. Chisholm, Andrew Whiting and A. Catharine Ross
