Testicular Cancer - Pipeline Insight, 2024

This “Testicular Cancer- Pipeline Insight, 2024” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Testicular Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Testicular Cancer: Understanding

Testicular Cancer: Overview

Testicular cancer is a disease in which malignant (cancer) cells form in the tissues of one or both testicles. The testicles are 2 egg-shaped glands located inside the scrotum (a sack of loose skin that lies directly below the penis). The testicles are held within the scrotum by the spermatic cord, which also contains the vas deferens and vessels and nerves of the testicles. Almost all testicular cancers start in the germ cells. The two main types of testicular germ cell tumors are seminomas and nonseminomas. These 2 types grow and spread differently and are treated differently. Non-seminomas tend to grow and spread more quickly than seminomas. Seminomas are more sensitive to radiation. A testicular tumor that contains both seminoma and non-seminoma cells is treated as a non-seminoma. The stages that are used for testicular cancer are: Stage 0, Stage I, Stage II,and Stage III.

Germ-cell tumors are observed to develop secondary to a tumorigenic event in utero that leads to intratubular germ-cell neoplasia. Intratubular germ-cell neoplasia is derived from gonocytes that have failed to differentiate into spermatogonia. These cells do not attain invasive potential until after hormonal changes occur during puberty. Seminomas consist of transformed germ cells that are blocked in their differentiation. Embryonal carcinoma cells resemble undifferentiated stem cells, and their gene expression is similar to those of stem cells and intratubular germ-cell neoplasms. Choriocarcinomas and yolk-sac tumors have extraembryonic differentiation, and teratomas have somatic differentiation.

Several genetic loci that confer a predisposition to testicular cancer have been identified. The variant with the highest impact was detected at 12q21, the genes encoding the proteins involved in KITLG-KIT signaling. The development of intratubular germ-cell neoplasia may involve aberrantly activated KITLG-KIT in utero, which induces arrest of embryonic germ cells at the gonocyte stage; subsequently, overexpression of embryonic transcription factors such as NANOG, sex-determining-region Y-box 17 (SOX17), and octamer-binding transcription factor 3-4 (OCT3/4, also known as POU domain, class 5, transcription factor 1 [POU5F1]) leading to suppression of apoptosis, increased proliferation, and accumulation of mutations in gonocytes.

Treatment of testicular cancer requires cooperative evaluation by urologists, medical oncologists, and radiation oncologists. Expert radiologic evaluation during surveillance is mandatory to detect recurrent disease. Careful pathologic evaluation is needed to describe different components of seminomatous and non-seminomatous germ cell tumors or GCNIS within specimens. Multidisciplinary discussions and planning result in the optimization of treatment, which results in an excellent prognosis for testicular cancer patients within all risk categories.

High doses of chemotherapy are given to kill cancer cells. Healthy cells, including blood-forming cells, are also destroyed by the cancer treatment. Stem cell transplant is a treatment to replace the blood-forming cells. Stem cells (immature blood cells) are removed from the blood or bone marrow of the patient or a donor and are frozen and stored. After the patient completes chemotherapy, the stored stem cells are thawed and given back to the patient through an infusion. These reinfused stem cells grow into (and restore) the body's blood cells. Prompt diagnosis and treatment are crucial since testicular malignancy has excellent cure rates due to high chemo-sensitivity with modern cisplatin-based chemotherapy, radio-sensitivity, and surgical excision with orchiectomy or retroperitoneal lymph node dissection. Different types of treatments are available for patients with testicular cancer. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Testicular Cancer R&D. The therapies under development are focused on novel approaches to treat/improve Testicular Cancer.

Testicular Cancer Emerging Drugs Chapters

This segment of the Testicular Cancer report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Testicular Cancer Emerging Drugs

Cabazitaxel: Sanofi Cabazitaxel is a taxanes and abeotaxane derivative, acts as an anti-neoplastic agent. It is formulated as injectable concentrated solution for intravenous route of administration. It is prepared using a precursor which is extracted from yew needles by semi-synthesis method. It is indicated for the treatment in patients with hormone refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen. Cabazitaxel is under development for treatment of adrenocortical carcinoma, testicular cancer, solid tumor, glioblastoma, brain metastasis. Currently the drug is in Phase II stage of Clinical trial evaluation for the treatment of Testicularcancer.

SGN-ALPV: Seagen SGN-ALPV is under development for the treatment of solid tumors, ovarian cancer, endometrial cancer, non-small cell lung cancer (NSCLC), testicular cancer, gastric cervical cancer, malignant testicular germ cell tumor and hematological malignancies. It is administered through intravenous route. It is an antibody drug conjugate (ADC). It acts by targeting cells expressing alkaline phosphatase placental type (ALPP) and alkaline phosphatase placental-like 2 (ALPPL2). Currently the drug is in Phase I stage of Clinical trial evaluation for the treatment of Testicularcancer.

Testicular Cancer: Therapeutic Assessment

This segment of the report provides insights about the different Testicular Cancer drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Testicular Cancer

• There are approx. 5+ key companies which are developing the therapies for Testicular Cancer. The companies which have their Testicular Cancer drug candidates in the most advanced stage, i.e. Phase II include, Sanofi

Phases

This report covers around 5+ products under different phases of clinical development like

• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration

Testicular Cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Oral
• Intravenous
• Subcutaneous
• Parenteral
• Topical

Molecule Type

Products have been categorized under various Molecule types such as

• Recombinant fusion proteins
• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Testicular Cancer: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Testicular Cancer therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Testicular Cancer drugs.

Testicular Cancer Report Insights

• Testicular Cancer Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Testicular Cancer Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

• How many companies are developing Testicular Cancer drugs?
• How many Testicular Cancer drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Testicular Cancer?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Testicular Cancer therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Testicular Cancer and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• LeadArtis
• Seagen
• BioNTech
• Sanofi

Key Products

• LEAD-472
• SGN-ALPV
• BNT211
• Cabazitaxel

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