Liver Cancer - Pipeline Insight, 2024

This “Liver Cancer - Pipeline Insight, 2024” report provides comprehensive insights about 70+ companies and 75+ pipeline drugs in Liver Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Liver Cancer: Understanding

Liver Cancer: Overview

Cancer is a disease in which cells in the body grow out of control. When cancer starts in the liver, it is called liver cancer. Each year in the United States, about 25,000 men and 11,000 women get liver cancer, and about 19,000 men and 9,000 women die from the disease. The percentage of Americans who get liver cancer rose for several decades, but is now declining. Liver cancer is more common in other parts of the world than in the United States. Primary liver cancer, or hepatocellular carcinoma (HCC), is the fifth most common cancer in males and the seventh most common cancer in females, and is the third leading cause of cancer-related death worldwide. Hepatocellular carcinoma (HCC), the primary cancer of the liver, is derived from hepatocytes and occurs in more than approximately 80% of cases of liver cancer. The HCC carcinogenesis is often associated with liver cirrhosis resultant from chronic liver diseases as chronic hepatitis, HBV or HCV infection, and autoimmune hepatitis. Other risk factors include excessive alcohol consumption, NASH, non-alcoholic fatty liver disease (NAFLD), exposure and ingestion of aflatoxin, diabetes mellitus, tobacco, and sporadically genetic diseases such as alpha-1 antitrypsin deficiency, hemochromatosis, tyrosinemia, porphyria and Wilson’s disease.

The common symptoms associated with liver cancer includes weakness and tiredness, pain in the abdomen, swelling of the abdomen due to a build-up of fluid (ascites), pain in the right shoulder, appetite loss and feeling sick, weight loss, yellowing of the skin and eyes (jaundice), pale bowel motions, fever. Liver cancer symptoms are more likely to appear as the cancer grows or becomes advanced.

Tests to diagnose both liver cancer and secondary cancer of the liver include blood tests, ultrasound, CT scan, MRI, PET-CT scan, biopsy. The most common treatments for primary liver cancer are tumor ablation and chemotherapy delivered directly into the cancer. The most common treatments for secondary cancer in the liver are chemotherapy or a combination of surgery and chemotherapy other options is Tumor ablation. Chemotherapy, Biological therapy, Selective internal radiation therapy (SIRT) this is used for both primary and secondary cancers in the liver when the tumors can't be removed with surgery. Endoscopic stent placement used when the cancer in the liver has obstructed the bile duct and bile has then built up in the liver, it may be recommended that a stent (thin tube) is placed in liver to drain the bile and ease symptoms.

“Liver Cancer - Pipeline Insight, 2024 report outlays comprehensive insights of present scenario and growth prospects across the mechanism of action. A detailed picture of the Liver Cancer pipeline landscape is provided which includes the disease overview and Liver Cancer treatment guidelines. The assessment part of the report embraces, in depth Liver Cancer commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Liver Cancer collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Liver Cancer R&D. The therapies under development are focused on novel approaches to treat/improve Liver Cancer.

Liver Cancer Emerging Drugs Chapters

This segment of the Liver Cancer report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Liver Cancer Emerging Drugs

Namodenoson: Can-Fite Bio Pharma Namodenoson is an oral small molecule drug generically known as Cl-IB-MECA (2-chloro-N6-(3-iodobenzyl)-adenosine-5'- N-methyl-uronamide), a highly specific and selective agonist at the A3 adenosine receptor (A3AR). Namodenoson's mechanism of action is mediated via deregulation of the NF-?B and Wnt signal transduction pathways, resulting in the apoptosis of tumor cells. The protective effect of Namodenoson is mediated via down-regulation of the NF-kB signal transduction pathway and preventing apoptosis. Namodenoson has a potent anti-cancer effect, particularly against hepatocellular carcinoma, and anti-inflammatory activity demonstrated in pre-clinical animal models of liver inflammation. The safety of Namodenoson has been demonstrated in preclinical studies, and Phase I and Phase II clinical studies demonstrating a favorable safety profile. Currently, the drug is in Phase III stage of its development for the treatment of advanced liverCancer.

YIV-906: Yiviva YIV-906 (also PHY906 or KD018) is a therapeutic candidate comprised of a proprietary c GMP botanical extract of four herbs inspired by a traditional Chinese medicine formulation used for over a millennium. YIV-906 has the potential to be developed as a platform oncology therapeutic when administered in combination with chemotherapy, immunotherapy and radiation therapies, in multiple cancer indications. YIV-906 has been shown to enhance immune function in the tumor microenvironment (by polarizing M1 macrophages and activating T cells), protect the gastrointestinal tract (by inhibiting inflammation via IL-6, NF-kappa-B, COX2, and iNOS pathways) and promote intestinal tissue repair (by increasing activity and expression of components of the Wnt signaling pathway). YIV-906 has been observed to enhance the anti-tumor activity of sorafenib in preclinical models of hepatocellular carcinoma and has shown promise in preliminary clinical studies in liver, pancreatic, colorectal and rectal cancers. Currently, the drug is in Phase II stage of its clincal trial for the treatment oflivercancer.

TTI-101: Tvardi Therapeutics TTI-101 is an orally bioavailable, small-molecule inhibitor of signal transducer and activator of transcription 3 (STAT3), a transcription factor whose upregulation and activation governs many hallmarks of cancer, inflammation, and fibrosis. Preclinically, TTI-101 has demonstrated an excellent pharmacokinetic profile, potency in attenuating pY705-STAT3 phosphorylation, and efficacy in inhibiting tumor growth in xenograft and syngeneic tumor models. Currently, the drug is in Phase II stage of clinical trial.

STP707: Sirnaomics STP707, our second key product, is in early-stage development for the treatment of solid tumors, liver cancer. STP707 is an intravenously administered TGF-ß1 and COX-2 inhibitor that leverages an RNAi-based response using the company’s proprietary PNP delivery platform. Currently, the drug is in Phase I stage of its clinical trial for the treatment of livercancer.

Liver Cancer: Therapeutic Assessment

This segment of the report provides insights about the different Liver Cancer drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Liver Cancer

There are approx. 70+ key companies which are developing the therapies for Liver Cancer. The companies which have their Liver Cancer drug candidates in the most advanced stage, i.e. Phase III include Can-Fite BioPharma,

Phases

This report covers around 75+ products under different phases of clinical development like

• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration

Liver Cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Intra-articular
• Intraocular
• Intrathecal
• Intravenous
• Oral
• Parenteral
• Subcutaneous
• Topical
• Transdermal

Molecule Type

Products have been categorized under various Molecule types such as

• Oligonucleotide
• Peptide
• Small molecule

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Liver Cancer: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Liver Cancer therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Liver Cancer drugs.

Liver Cancer Report Insights

• Liver Cancer Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Liver Cancer Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

• How many companies are developing Liver Cancer drugs?
• How many Liver Cancer drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Liver Cancer?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Liver Cancer therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Liver Cancer and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Arcus Biosciences
• Yiviva
• Virogin Biotech
• Tvardi Therapeutics
• GlaxoSmithKline
• TORL Biotherapeutics
• AVEO Pharmaceuticals
• Teclison
• Epizyme
• Sirnaomics
• Coherus Biosciences
• Sinocelltech Ltd.
• Qurient Co
• Hoffmann-La Roche
• Can-Fite BioPharma
• Omega Therapeutics
• Novita Pharmaceuticals
• Bristol-Myers Squibb

Key Products

• Zimberelimab
• YIV-906
• VG161
• TTI-101
• TSR-022 and TSR-042
• TORL-4-500
• Tivozanib
• Tirapazamine
• Tazemetostat
• STP705
• SRF388
• SD-101
• Q702
• GC33
• Namodenoson
• OTX-2002
• NP-G2-044
• Nivolumab

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